精神分裂症

•consciousness : maintained
•intelligence : intact •natural course :chronic remitting but some times deteriorating
2. Epidemiology of schizophrenia
•How common is schizophrenia?
“One Flew Over the Cuckoo's Nest”
(1) Perception (2) Thought & association (3) Affect (4) Volition (5) Other disturbances
clinical manifestation are Complicated & Diverse
No one case can show all the symptoms
Symptoms
Hallucinations Most reported are hearing voices Delusions Often bizarre or persecutory in nature Thought disorder Disorganized thinking and speech
4. Subtypes PART1:Schizophrenia 8. Treatment 5. Etiology & pathogenesis 6. Diagnosis & differential diagnosis 7. Course & prognosis
1. Definition of schizophrenia
Onset is usually in late adolescence Substance abuse is a co-morbid condition in 50% of schizophrenia patients
Broad Impairments Delusions & Hallucinations
Worldwide
※ Lifetime prevalence rate in adult: 1% ※ Peak age: 15-24(M)，25-29(F) ※ Gender:M:F=1：1.6 ※ Economy(-), rural>urban
※ Currently 8 million nationwide，annual growth 300 thousand，10% violence tendency
Medieval （A.D. 476 years to the seventeenth century）： Theological and religious influence:“witch persecution”and“Stupid stone”
Modern times（The late 17th century to the18th ）：
Schizophrenia
[ˌskitsəuˈfri:niə]
YuYu（Fanny） Xiangya hospital of CSU
What is Schizophrenia?
Schizophrenia is a mental disorder characterized by a disturbance of thought, emotion and behavior. The lifetime prevalence of schizophrenia is about 1%
Disorganized Speech & Behavior
Inappropriate Emotions Psychosis: extreme mental unrest with
loss of reality contact (Davison & Neale, p. 134)
review
French Pinel “madhouse”——hospital
the mid-nineteenth century:
In 1857，French Morel: Dementia
(Loss of Mind) In 1871, Germany Hecker: Praecox (Early, Premature) In 1874,Germany Kahlbaum: Catatonia In 1896,Germany Kraepelin: “Dementia Precox”/“Youth Dementia” Categorization & Early Onset In 1911,Switzerland Eugen Bleuler Termed ―Schizophrenia‖ Associative Splitting
Outcome： •50% ----- try to suicide •10% ----- died (due to self-killed)
Chlorpromazine/ CPZ
N
2Leabharlann Baidu
Other psychosis
20%
80%
1
schziophrenia
3. Clinical Features
Schiz(separation)
Phrenia
Spirit cancer
• A group of psychotic disorders of unknown specified etiology
• Presented with a gradual onset of abnormalities in perception, thought, emotion & behavior
organic ? mental disorders
? functional ? mild ? major
neurosis •Schizophrenia •Mania-depression
•Other psychotic
disorders
3. Clinical features
2. Epidemiology 1. Definition