药学英语
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事实上,少量的(低于5%)(无效对映异构体)可以在 紫外线或质谱分析检测。
The last one is especially useful for the study of compounds during stresscondition study of pharmaceutical active ingredients.
It is one of the preferred antidote for immediate management of toxicity associated with nerve agents.
这是首选的解毒剂之一,即时管理与神经毒剂的毒性。
Stereoselective separation was achieved with a prepacked α-1 acid glycoprotein column without any derivatization procedure.
最后一个是在强调药物有效成分的条件研究的化合物的 研究特别有用。
It must be shown that method is specific and that no degradation product could appear under one of the peaks.
它必须证明该方法是具体的,没有降解产物下可能出现 的高峰。
摘要:
对映异构体的分离与定量和对映异构体纯度的测定是当 前不可缺少的的药物分析的任务。
Among the various techniques, liquid chromatography remains the best modality owing to several advantages.
另一方面,作为反离子使用的辛酸,似乎是至关重要的。
Despite the low loading capacity of AGP, it allows a sufficient resolution of the enantiomers of atropine.
尽管AGP低负荷能力,它允许阿托品对映体的足够高的 分辨率。
在各种技术中,由于几个优势,液相色谱仪仍然是最 好的方式。
High speed, sensitivity, and reproducible results make LC the method of choice in almost all laboratories.
速度快,灵敏度高和可重复性好,使几乎所有的实验室 都选择液相色谱。
Hale Waihona Puke Baidu
Phases that contain α-1 acid glycoprotein as chiral selector are suitable for separation of charged and uncharged enantiomers with widely different structure.
色谱分离分析物在选择离子监测中使用阶乘的实验设计优 化后被发现。少量的对映体组成就可以通过MS或紫外光 谱(小于5%)进行评估。
Conclusion: :
The chiral separation using a narrow bore AGP column (2mmI.D.) depends to a high degree on the chromatographic conditions, particularly organic solvent amount and pH as shown in our study.
结论: 结论:
手性分离,使用窄径AGP柱(2mmI.D.)取决于高度上 的色谱条件下,特别是有机溶剂的用量,在我们的研究 显示pH值。
On the other hand, the use of octanoic acid as a counter ion seems to be critical.
各期包含α-1酸性糖蛋白,分离适合带电和不带电的结 构有很大不同对映体,作为手性选择。
Atropine is widely used as parasympatolytic, anticholinergic and antiemetic drugs.
阿托品被广泛用作副交感神经阻滞药,抗胆碱能和止吐 药。
在正离子模式下,用一个大气压化学电离接口耦合液相 色谱系统和质谱。
The chromatographed analytes are detected in selective ion monitoring after optimisation using factorial experimental design. Small amount of enantiomeric composition can be evaluated either by MS or by UV spectrometry (less than 5%).
通过一个预装的α-1酸性糖蛋白柱,没有任何衍生过程 的立体选择性被分离实现。
The liquid chromatography system is coupled to mass spectrometry with an atmospheric pressure chemical ionization interface in the positive-ion mode
Chiral separation of atropine by high-performance liquid chromatography 阿托品高性能高效液相色谱法的手性 分离
Abstract:
The separation and quantitation of the enantiomers and also the determination of the enantiomeric purity are now current and indispensable tasks for the pharmaceutical analysis.
Moreover, the less d-enantiomer is present, the best is the separation.
此外,D-对映异构体很少存在,最好的是分离的。
Indeed, small amount (less than 5%) of the distomer (inactive enantiomer) could be detected either in UV or mass-spectrometry.