抗生素英文课件精品 Antibioticsand Antibiotic resistance
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• http://student.ccbcmd.edu/courses/bio141/lecgui de/unit6/genetics/protsyn/translation/translation. html
Bacterial resistance to antibiotics
Producing an Enzyme to Destroy or Inactivate the Antibiotic
Mode of Action of Macrolides in Blocking Translation: Blocking Peptidyltransferase
macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind to the 50S subunit
Gary Kaiser
Bacterial resistance to antibiotics
Producing Transporter Mo来自百度文库ecules to Pump the Drug Out of the Bacterium
Gary Kaiser
http://student.ccbcmd.edu/courses/bio141/lecguide/unit2/control/aglyconoAP_anim.html
Animation of Tetracyclines Blocking Translation
http://student.ccbcmd.edu/courses/bio141/lecguide/unit2/control/tetres.html
Cross-Links in Peptidoglycan
Penicillins and cephalosporins bind to the transpeptidase enzyme and block the formation of the peptide cross-links. This results in a weak cell wall and osmotic lysis of the bacterium. Gary Kaiser
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/genetics/resist/enz.html Gary Kaiser
Bacterial resistance to antibiotics
Producing an Altered Target Site to which the Antibiotic no Longer Binds
Antibiotics Antibiotic resistance
Animations from lecture
Synthesis of Peptidoglycan
During normal bacterial growth, bacterial enzymes called autolysins put breaks in the peptidoglycan in order to allow for insertion of peptidoglycan building blocks (monomers of NAG-NAM-peptide). Transpeptidase enzymes join the peptide of one monomer with that of another in order to provide strength to the cell wall.
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/genetics/resist/altrib.html Gary Kaiser
Bacterial resistance to antibiotics
Producing an Altered Porin in the Outer Membrane of a Gram-Negative Cell Wall
Animation – Mechanisms of antibiotics
• Antibiotics: Methods of control
http://student.ccbcmd.edu/courses/bio141/lecgui de/unit2/control/antibio.html
• Antibiotics that inhibit translation
Aminoglycosides Interfering with the Translocation of tRNA from the A-site to the P-site
• Aminoglycosides (streptomycin, neomycin, netilmicin, tobramycin, gentamicin, amikacin, etc)
Gary Kaiser
http://www.cat.cc.md.us/courses/bio141/lecguide/unit2/control/ppgsynanim.html
Animation Illustrating the Role of Penicillins in Blocking Transpeptidase Enzymes from Assembling the Peptide
Bacterial resistance to antibiotics
Producing an Enzyme to Destroy or Inactivate the Antibiotic
Mode of Action of Macrolides in Blocking Translation: Blocking Peptidyltransferase
macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind to the 50S subunit
Gary Kaiser
Bacterial resistance to antibiotics
Producing Transporter Mo来自百度文库ecules to Pump the Drug Out of the Bacterium
Gary Kaiser
http://student.ccbcmd.edu/courses/bio141/lecguide/unit2/control/aglyconoAP_anim.html
Animation of Tetracyclines Blocking Translation
http://student.ccbcmd.edu/courses/bio141/lecguide/unit2/control/tetres.html
Cross-Links in Peptidoglycan
Penicillins and cephalosporins bind to the transpeptidase enzyme and block the formation of the peptide cross-links. This results in a weak cell wall and osmotic lysis of the bacterium. Gary Kaiser
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/genetics/resist/enz.html Gary Kaiser
Bacterial resistance to antibiotics
Producing an Altered Target Site to which the Antibiotic no Longer Binds
Antibiotics Antibiotic resistance
Animations from lecture
Synthesis of Peptidoglycan
During normal bacterial growth, bacterial enzymes called autolysins put breaks in the peptidoglycan in order to allow for insertion of peptidoglycan building blocks (monomers of NAG-NAM-peptide). Transpeptidase enzymes join the peptide of one monomer with that of another in order to provide strength to the cell wall.
http://www.cat.cc.md.us/courses/bio141/lecguide/unit4/genetics/resist/altrib.html Gary Kaiser
Bacterial resistance to antibiotics
Producing an Altered Porin in the Outer Membrane of a Gram-Negative Cell Wall
Animation – Mechanisms of antibiotics
• Antibiotics: Methods of control
http://student.ccbcmd.edu/courses/bio141/lecgui de/unit2/control/antibio.html
• Antibiotics that inhibit translation
Aminoglycosides Interfering with the Translocation of tRNA from the A-site to the P-site
• Aminoglycosides (streptomycin, neomycin, netilmicin, tobramycin, gentamicin, amikacin, etc)
Gary Kaiser
http://www.cat.cc.md.us/courses/bio141/lecguide/unit2/control/ppgsynanim.html
Animation Illustrating the Role of Penicillins in Blocking Transpeptidase Enzymes from Assembling the Peptide