目的对胃癌根治术后并发症进行clavien—Dindo分级并探讨并发症

胃癌D2根治术后并发症的Clavien-Dindo分级及危险因素分析

张超张文俊滁州市第二人民医院

【摘要】目的: 对胃癌D2根治术后的并发症进行危险因素分级，并探讨其发生主要危险因素。方法:回顾性收集172例行胃癌D2根治术的患者的临床资料，根据术后是否出现并发症分为并发症组30例和对照组142例。对两组患者性别、年龄、有无基础疾病、手术时间、手术方式、失血量及术后病理分期等临床病理资料进行Logistic回归分析。结果:术后并发症的总发生率为17.44％(30例)，Clavien-Dindo分级Ⅱ、Ⅲ、Ⅳ和Ⅴ级并发症的发生率分别为20例(11.62％)、8例(4.65％)、1例(0.58％)和1例(0．58％)。与对照组相比，并发症组有术前基础疾病[60.00%（18例）比32.39%（46例）P<0．01]，且围手术期输血比例更高[50.00％(15例)比26.06％(37例)，P<0.01]，而性别、年龄、切除方式、重建方式、淋巴结转移数目、手术失血量、手术时间和术后病理分期等差异均无统计学意义(均P>0.05)。单因素分析发现存在基础疾病、术前ASA分级（美国麻醉医师协会评分）≥Ⅱ级、联合脏器切除、和围手术期输血与胃癌D2根治术后并发症的发生有关(均P<0.05)。进一步行多因素分析围手术期输血(OR = 3.14，95% CI：1.36～7.25，P = 0.007)和术前基础疾病(OR = 2.58，95% CI：1.12～5.96，P = 0.027)是胃癌根治术后发生并发症的独立风险因素。结论：Clavien-Dindo 分级标准应用于胃癌D2根治术后并发症分级，有助于对胃癌手术安全性进行综合比较和评价，加强术前基础疾病处理和尽量减少围手术期输血可能降低术后并发症发生率。

【关键词】胃癌；D2根治术；并发症；Clavien-Dindo

ABSTRACT

Objective: This study aims to perform a risk factor analysis of complications after D2 radical resection of gastric cancer, and to explore the main risk factors of postoperative complications. Methods: We collected the clinical data of 172 patients with D2 radical gastrectomy for gastric cancer retrospectively. 30 cases were divided into experimental group and 142 cases in control group according to postoperative complications. Logistic regression analysis was performed on the two groups of patients with clinical data such as gender, age, complications, operation time, operation mode, blood loss and postoperative pathological stage.

Results: The total incidence of postoperative complications was 17.44% (30 cases). The incidence of Clavien-Dindo grade II, III, IV and V were 20 (11.62%), 8 cases (4.65%), 1 case (0.58%) and 1 cases (0.58%). Compared with the control group, the experimental group had a higher incidence of preoperative complications [60.00% (18 cases) ,32.39% (46 cases), P<0.01], and a higher risk for perioperative blood transfusion [50.00% (17 cases) than 26.06% (37 cases), P<0.01 ]. But the differences of gender, age, excision, reconstruction, lymph node metastases, surgical blood loss, operative time and postoperative pathological staging showed no statistical significance (P > 0.05). Single factor analysis revealed that the presence of complications, preoperative grading of ASA (American Society of Anesthesiologists score) more than grade II, combined organ resection, and perioperative transfusion were related to the complications after D2 radical resection (P < 0.05). Further multivariate analysis showed that perioperative blood transfusion (OR = 3.14, 95% CI:1.36 ~ 7.25 , P = 0.007) and preoperative complications (OR = 2.58, 95% CI:1.12 ~ 5.96, P = 0.027) were independent risk factors of postoperative complications .

Conclusions:Application of Clavien-Dindo grading standards in D2 radical postoperative complications is helpful to the comprehensive comparison and evaluation of gastric cancer surgical safety. Strengthen the treatment of preoperative complications and reduce perioperative