病理学之免疫性疾病
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病理学
免疫性疾病
Disorders of the Immune System
提要
自身免疫性疾病 免疫缺陷病 器官和骨髓移植
自身免疫性疾病
自身免疫性疾病（Autoimmune disease）
器官或细胞特异性自身免疫性疾病
机体自身产生的抗体或致敏淋巴细胞，破坏、损伤
自身的组织和细胞成分，导致组织损害和器官功能障碍
发病因素
遗传因素 免疫因素 其他
血细胞的损伤和溶解
血管和肾小球病变 全血细胞减少
系统性红斑狼疮
病理变化:
抗核抗体攻击变性或胞膜受损的细胞，细胞核肿胀，呈
均质一片，并被挤出胞体，形成狼疮小体（苏木素小体）
为诊断SLE的特征性依据
吞噬了狼疮小体的中性粒细胞或巨噬细胞称为狼疮细胞
http://www.xasg120.com/fkzl/ http://www.xasg120.com/fkzl/lc/ http://www.xaswk.baidu.com120.com/fkzl/wy/ http://www.xasg120.com/fkzl/yd/ http://www.xasg120.com/fkzl/zgjl/ http://www.xasg120.com/fuke/ http://www.xasg120.com/fuke/fujiany an/ http://www.xasg120.com/fuke/gjy/ http://www.xasg120.com/fuke/ndy/ http://www.xasg120.com/fuke/pqy/ http://www.xasg120.com/fuke/ydy/ http://www.xasg120.com/fuke/zigongneimoy an/ http://www.xasg120.com/gongjing/ http://www.xasg120.com/gongjing/fei da/ http://www.xasg120.com/gongjing/gongjingai / http://www.xasg120.com/gongjing/mi lan/ http://www.xasg120.com/gongjing/xir ou/ http://www.xasg120.com/gongjing/ya nzheng/ http://www.xasg120.com/jbzs/ http://www.xasg120.com/jhsy/ http://www.xasg120.com/jhsy/gwy/ http://www.xas g120.com/jhs y/jiancha / http://www.xasg120.com/jhsy/shanghuanquhuan/ http://www.xasg120.com/jhsy/wtrl/ http://www.xas g120.com/jhs y/wuton gyincha n/ http://www.xasg120.com/jhsy/yaoliu/ http://www.xasg120.com/jryuyue/ http://www.xasg120.com/weichuangf uke/ http://www.xasg120.com/yyhj/ http://www.xasg120.com/zhengxing/c nmxf/ http://www.xasg120.com/zhengxing/x yczx/ http://www.xasg120.com/zhengxing/y djss/ http://www.xasg120.com/zhengxing/y dzx/
--系统性红斑狼疮
（Systemic lupus erythematosus, SLE)
--类风湿关节炎
（Rheumatoid arthritis, RA)
系统性红斑狼疮
病因和发病机制：免疫耐受的丧失和自身抗体的产生
自身抗体的形成--抗核抗体
DNA-抗DNA复合物 抗红细胞、血 小板等抗体
Ⅲ型变态反应 Ⅱ型变态反应
的原发性免疫性疾病
系统性自身免疫性疾病
http://www.029nk.com/fkyz/ http://www.029nk.com/byby/ http://www.029nk.com/fkzl/ http://www.029nk.com/gjjb/ http://www.029nk.com/jhsy/ http://www.029nk.com/fkzx/ http://www.029nk.com/gjjb/gjml/ http://www.029nk.com/fkyz/ydy/ http://www.029nk.com/fkzl/zgjl/ http://www.029nk.com/byby/byjc/ http://www.029nk.com/fkzx/cvmxf/ http://www.029nk.com/jhsy/rljs/ http://www.029nk.com/fkyz/bdyc/ http://www.029nk.com/byby/nxby/ http://www.029nk.com/fkzx/yczx/ http://www.029nk.com/jhsy/wtrl/ http://www.029nk.com/jhsy/yaoliu/ http://www.029nk.com/gjjb/gjxr/ http://www.029nk.com/fkyz/fjy/ http://www.029nk.com/fkzl/lcnz/ http://www.029nk.com/byby/byzl/ http://www.029nk.com/jhsy/gwy/ http://www.029nk.com/byby/lcxby/ http://www.029nk.com/fkzx/ydjs/ http://www.029nk.com/jhsy/jyzs/ http://www.029nk.com/gjjb/gjfd/ http://www.029nk.com/fkyz/pqy/ http://www.029nk.com/fkzl/ydnz/ http://www.029nk.com/byby/byyy/ http://www.029nk.com/fkzx/yjbt/ http://www.029nk.com/gjjb/gjy/ http://www.029nk.com/fkyz/ndy/ http://www.029nk.com/fkzx/ydzx/ http://www.029nk.com/byby/gjxby/ http://www.029nk.com/fkzx/ydzz/ http://www.029nk.com/jhsy/zyjc/
免疫性疾病
Disorders of the Immune System
提要
自身免疫性疾病 免疫缺陷病 器官和骨髓移植
自身免疫性疾病
自身免疫性疾病（Autoimmune disease）
器官或细胞特异性自身免疫性疾病
机体自身产生的抗体或致敏淋巴细胞，破坏、损伤
自身的组织和细胞成分，导致组织损害和器官功能障碍
发病因素
遗传因素 免疫因素 其他
血细胞的损伤和溶解
血管和肾小球病变 全血细胞减少
系统性红斑狼疮
病理变化:
抗核抗体攻击变性或胞膜受损的细胞，细胞核肿胀，呈
均质一片，并被挤出胞体，形成狼疮小体（苏木素小体）
为诊断SLE的特征性依据
吞噬了狼疮小体的中性粒细胞或巨噬细胞称为狼疮细胞
http://www.xasg120.com/fkzl/ http://www.xasg120.com/fkzl/lc/ http://www.xaswk.baidu.com120.com/fkzl/wy/ http://www.xasg120.com/fkzl/yd/ http://www.xasg120.com/fkzl/zgjl/ http://www.xasg120.com/fuke/ http://www.xasg120.com/fuke/fujiany an/ http://www.xasg120.com/fuke/gjy/ http://www.xasg120.com/fuke/ndy/ http://www.xasg120.com/fuke/pqy/ http://www.xasg120.com/fuke/ydy/ http://www.xasg120.com/fuke/zigongneimoy an/ http://www.xasg120.com/gongjing/ http://www.xasg120.com/gongjing/fei da/ http://www.xasg120.com/gongjing/gongjingai / http://www.xasg120.com/gongjing/mi lan/ http://www.xasg120.com/gongjing/xir ou/ http://www.xasg120.com/gongjing/ya nzheng/ http://www.xasg120.com/jbzs/ http://www.xasg120.com/jhsy/ http://www.xasg120.com/jhsy/gwy/ http://www.xas g120.com/jhs y/jiancha / http://www.xasg120.com/jhsy/shanghuanquhuan/ http://www.xasg120.com/jhsy/wtrl/ http://www.xas g120.com/jhs y/wuton gyincha n/ http://www.xasg120.com/jhsy/yaoliu/ http://www.xasg120.com/jryuyue/ http://www.xasg120.com/weichuangf uke/ http://www.xasg120.com/yyhj/ http://www.xasg120.com/zhengxing/c nmxf/ http://www.xasg120.com/zhengxing/x yczx/ http://www.xasg120.com/zhengxing/y djss/ http://www.xasg120.com/zhengxing/y dzx/
--系统性红斑狼疮
（Systemic lupus erythematosus, SLE)
--类风湿关节炎
（Rheumatoid arthritis, RA)
系统性红斑狼疮
病因和发病机制：免疫耐受的丧失和自身抗体的产生
自身抗体的形成--抗核抗体
DNA-抗DNA复合物 抗红细胞、血 小板等抗体
Ⅲ型变态反应 Ⅱ型变态反应
的原发性免疫性疾病
系统性自身免疫性疾病
http://www.029nk.com/fkyz/ http://www.029nk.com/byby/ http://www.029nk.com/fkzl/ http://www.029nk.com/gjjb/ http://www.029nk.com/jhsy/ http://www.029nk.com/fkzx/ http://www.029nk.com/gjjb/gjml/ http://www.029nk.com/fkyz/ydy/ http://www.029nk.com/fkzl/zgjl/ http://www.029nk.com/byby/byjc/ http://www.029nk.com/fkzx/cvmxf/ http://www.029nk.com/jhsy/rljs/ http://www.029nk.com/fkyz/bdyc/ http://www.029nk.com/byby/nxby/ http://www.029nk.com/fkzx/yczx/ http://www.029nk.com/jhsy/wtrl/ http://www.029nk.com/jhsy/yaoliu/ http://www.029nk.com/gjjb/gjxr/ http://www.029nk.com/fkyz/fjy/ http://www.029nk.com/fkzl/lcnz/ http://www.029nk.com/byby/byzl/ http://www.029nk.com/jhsy/gwy/ http://www.029nk.com/byby/lcxby/ http://www.029nk.com/fkzx/ydjs/ http://www.029nk.com/jhsy/jyzs/ http://www.029nk.com/gjjb/gjfd/ http://www.029nk.com/fkyz/pqy/ http://www.029nk.com/fkzl/ydnz/ http://www.029nk.com/byby/byyy/ http://www.029nk.com/fkzx/yjbt/ http://www.029nk.com/gjjb/gjy/ http://www.029nk.com/fkyz/ndy/ http://www.029nk.com/fkzx/ydzx/ http://www.029nk.com/byby/gjxby/ http://www.029nk.com/fkzx/ydzz/ http://www.029nk.com/jhsy/zyjc/