肝癌常见的高发突变基因

肝癌常见的高发突变基因（前20位）：

序列号人基因小鼠基因突变频率

1 TP53 P53,Trp53 28%

2 TERT 21%

3 CTNNB1 Ctnnb1 Catnb 19%

4 AXIN1 Axin1 Axin,Fu 8%

7%

5 ARID1A Arid1a

Baf250,Baf250a,Os

a1,Smarcf1

6 CDKN2A 6%

7 ARID2 5%

8 KMT2C Kmt2c Mll3 4%

9 PIK3CA 3%

3% 10 HNF1A Hnf1a

Hnf-1,Hnf-1a,

Tcf1

11 ATM 3%

12 NFE2L2 Nfe2l2 Nrf-2,Nrf2 3%

13 TSC2 3%

14 RB1 Rb1 Rb-13%

15 CREBBP Crebbp Cbp3%

16 KMT2D Kmt2d Mll2,Mll43%

17 PTPRB P2rx7 P2x72%

18 IL6ST 2%

19 PTEN Pten Mmac12%

20 ATR Atr Kiaa40692%