介孔分子筛的表面修饰及其吸附性能研究

介孔分子筛的表面修饰及其吸附性能研究

摘要

本研究通过采用碱性室温晶化法合成MCM-41分子筛，在水热条件下，探索了采用CTMAB（十六烷基三甲基溴化胺）作为模板剂、TEOS（正硅酸乙酯）作为硅源合成MCM-41分子筛的工艺条件，通过MCM-41分子筛的合成后采用XRD和红外光谱等手段对所合成的分子筛样品进行了表征分析。探索MCM-41和MCM-41-NH2在相同条件下对布洛芬的吸附效果。

结果表明：利用此方法能够很好地合成MCM-41分子筛，并对材料进行后修饰，上氨基官能集团，并在同等实验条件下用两种材料进行药物负载与缓释实验，实验结果表明MCM-41和MCM-41-NH2都有一定的药物负载能力。吸附效果经过修饰的MCM-41-NH2优与修饰前的。

关键词：MCM-41分子筛；MCM-41-NH2分子筛；布洛芬；合成；药物缓释

MCM - 41 surface modification of mesoporous molecular sieve and its

adsorption performance

Abstract

Molecular sieve as one of a kind of important chemical materials, because of its neat, large specific surface area, porous water thermal stability, as well as the advantages of pore size is adjustable and is widely used in chemical, petrochemical and other fields. It can be used as a catalyst, absorbent, ion exchanger and other a variety of functional materials. This article USES the basic synthesis method of MCM - 41 molecular sieve, room temperature crystallization under hydrothermal conditions, explores the using CTMAB as template agent, TEOS as silicon source to synthesize MCM - 41 molecular sieve technology conditions, by using XRD and ftir methods for the synthesis of molecular sieve samples have been characterized. Explore the MCM - 41 and MCM - 41 - NH2under the same conditions of ibuprofen adsorption effect.

Results show that this method can effectively synthesize MCM - 41 molecular sieve, the same condition after amination of MCM - 41 - NH2 adsorption effect is better than MCM - 41. While the release effect of the two materials is poor.

Key Words：MCM - 41 molecular sieve; MCM - 41 - NH2molecular sieve; Ibuprofen；Synthesis; Drug release

目录

摘要..................................................................................................................................... I Abstract ..................................................................................................................................... II 第1章前言.. (1)

1.1 MCM-41分子筛的研究背景.................................................... 错误！未定义书签。

1.1.1MCM-41分子筛的定义 (1)

1.1.2 MCM-41分子筛合成机理研究............................................. 错误！未定义书签。

1.1.3协同作用机理 (2)

1..1.4电荷密度匹配机理 (3)

1.3 MCM-41分子筛的合成方法及影响因素 (3)

1.4缓控释制剂简介 (3)

1.5选题意义与实验目的 (4)

第2章实验部分 (5)

2.1实验药品与仪器 (5)

2.1.1实验药品 (5)

2.1.2实验仪器 (6)

2.2实验步骤 (6)

2.2.1 MCM-41分子筛的合成 (6)

2.2.2 MCM-41-NH2分子筛的合成 (6)

2.2.3乙醇中的布洛芬标准曲线的绘制 (9)

2.2.4正己烷中的布洛芬标准曲线的绘制 (10)

2.2.5布洛芬的装载过程 (7)

2.2.6 MCM-41分子和MCM-41-NH2载药释药性能 .............. 错误！未定义书签。

2.2.7 MCM-41和MCM-41-NH2分子筛分子筛材料的表征 (12)

第3章结论 (15)

第4章讨论 (18)

第5章谢辞 (18)

第6章参考文献 (19)