基于容积脉搏波的血压参数测量与标定的方法研究_丁有得

基于容积脉搏波的血压参数测量与标定的方法研究文章编号：1671-7104(2010)01-0004-05

【作者】【摘要】

【关键词】【中图分类号】【文献标识码】

【Writers 】【 Abstract 】

【Key words 】丁有得，邓亲恺*，梁妃学，郭劲松

南方医科大学基础医学院生物信息学研究室，广东，广州， 510515

提出通过人体指端一点位置测量脉搏波传播时间，进而标定收缩压、舒张压。具体方法是通过交替点亮红光和红外光获取容积脉搏波，经放大滤波及信号处理后得到加速脉搏波，通过测量其中推进波和反射波之间的脉搏波传播时间来建立与血压的关系。根据数据回归分析建立收缩压测量方程式，根据容积脉搏波中交直流成分之间存在的线性关系及数据回归分析，建立相应的舒张压测量方程式。通过临床33例人体实验，其中18人作为训练组，15人作为对照组，并与基于传统充气袖带测量的OMRON电子血压仪测量结果作对照验证，结果表明有较好的一致性。此方法简单易行，可望作为一种无创、连续血压参数测量的标定方法。

容积脉搏波；传播时间；收缩压；舒张压；标定

R443.8

A

Ding Youde, Deng Qinkai, Liang Feixue, Guo Jinseng

Institute of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Physiology parameters measurement based on volume pulse wave is suitable for the monitoring blood pressure continuously. This paper described that the systolic blood pressure（SBP） and diastolic blood pressure （DBP）can be calibrated by measuring the pulse propagation time, just on one point of fi nger tip. The volume pulse wave was acquired by lighting the red and infrared LED alternately, and after signal processing, an accelerated pulse wave was obtained. Then by measuring the pulse wave propagation time between the progressive wave and refl ected wave, we can fi nd the relationship of the time and the blood pressure, and establish the related systolic blood pressure measurement equation. At the same time, based on the relationship between alternating current and direct current components in the volume pulse waveforms and through regression analysising, the relevant diastolic blood pressure measurement equation can be established. 33 clinical experimentation cases have been worked by dividing them into two groups: training group (18 cases) and control group (15 cases), by comparing with the measuring results of the OMRON electronic sphygmomanometer. The results indicated that the two methods had good coherence. The measurement described is simple and reliable, and may be served as a new method for noninvasively and continuously measurement of blood pressure.

volume pulse wave, systolic blood pressure, diastolic blood pressure, Pulse Propagation time, blood pressure, calibrate

心血管血流参数的实时监护对心血管疾病诊断、治疗、手术麻醉期的临床监护、危重病人的抢救等有重要的作用。脉搏波能反映许多重要的心血管血流动力学信息，通过光电容积脉搏波无创测量心血管血流参数，由于其稳定性、适应性、重复性比较理想，特别适合于临床长时间的监护。随着科学技术的不断进步和国内外学者对容积脉搏血流信号的机理与信息特征的深入研究[1]，基于容积脉搏波的监护模块研究不再仅仅停留在血氧和脉率这两个指标上，获取血压参数信息也成为近年来研究的重点与热点[2~4]。此问题难点在于如何对容积脉搏血流进行标定，特别是如何建立起与血压的关系。目前的研究主要包括两种方法：一种是根据容积脉搏波和压力脉搏波之间的转换关系得到血压参量[1][5]；另一种是利用脉搏波传导时间测量出血压[6-7]。前者一般无法摆脱充气袖带的束缚和压力不断变化对人体的影响，长时间测量会给测试者带来不适感；后一种方法是近年来出现的一种新思路，无需充气袖带, 只要检测脉搏波传导时间, 即可间接推算出每搏血压值。已有的研究一般是测量不同位置两点心电信号与脉搏波信号，脉搏波信号与脉搏波信号，要求操作人员有一定的医学知识，对检测部位要求十分严格，操作不便。

为了克服上述两种测量方法的不足，本文提出只用指端一点检测脉搏波传导时间的方法，减少了测量过程中传感器对受试部位的影响因素，舒适性和方便性都获

A Calibrated Method for Blood Pressure

Measurement Based on Volume Pulse Wave

收稿日期：2009-11-11

通讯作者：邓亲恺，教授， E-mail: dqk001@fi