基于边缘频谱分析的针灸镇痛效果研究

第43卷第7期2009年7月

浙　江　大　学　学　报(工学版)

Journal of Zhejiang University (Engineering Science )

Vol.43No.7

J ul.2009

收稿日期:20080526.

浙江大学学报(工学版)网址:/eng

基金项目:浙江省自然科学基金资助项目(Y207207).

作者简介:童基均(1977-),男,浙江兰溪人,博士生,从事生物医学信号分析与生物医学传感技术研究.E 2mail :Jijuntong @

通讯联系人:陈裕泉,男,教授,博导.E 2mail :yqchen @

DOI :10.3785/j.issn.10082973X.2009.07.008

基于边缘频谱分析的针灸镇痛效果研究

童基均1,2,朱丹华2,陈裕泉2,陈华德3

(1.浙江大学生物医学工程系,浙江杭州310027;2.浙江理工大学信息电子学院,浙江杭州310018;

3.浙江中医药大学第三临床医学院,浙江杭州310053)

摘　要:为了对疼痛进行有效的治疗和控制以及得到疼痛的客观评价标准,通过建立人体疼痛实验模型,利用现代脑电分析技术从脑部神经电活动的调制研究针灸镇痛过程中脑电信号的特征变化,以取得针灸镇痛的中枢机制和客观评价标准.实验对12个志愿者建立疼痛模型,然后进行经皮穴位电刺激(TEAS )治疗以及不进行任何刺激治疗两组实验,记录实验过程中的脑电信号,提取边缘频谱(SEF )特征,同时对志愿者进行视觉模拟评分(VAS ).实验发现,SEF 在疼痛刺激后明显升高,然后逐渐降低,但是经皮穴位电刺激实验组降低速度更快,程度更高,这和V AS 具有相同的变化趋势.研究表明,经皮穴位电刺激具有一定的镇痛效果,并且SEF 有望成为疼痛的客观评价指标之一.关键词:疼痛;针灸;经皮穴位电刺激;边缘频谱分析;视觉模拟评分

中图分类号:R318.08 文献标识码:A 文章编号:1008973X (2009)07121404

E ffect of acupuncture in pain relief based on SE

F research

TON G Ji 2jun 1,2,ZHU Dan 2hua 2,C H EN Yu 2quan 2,C H EN Hua 2de 3

(1.De partment of B iomedical Engineering ,Zhej iang Universit y ,H angz hou 310027,China;2.College of I nf ormatics and Elect ronics ,Zhej iang Sci 2Tech Universit y ,H angz hou 310018,China;

3.T hi rd College of Clinical Medicine ,Zhej iang Universit y of T raditional Chinese Medicine ,Hangz hou 310053,China )

Abstract :To get effective cont rol ,t reat ment and o bjective assessment criterion of pain relief ,a pain model was constructed and modern elect roencep halograp h (EEG )signal p rocessing techniques were used to ana 2lyze t he modulation effect of acup unct ure on EEG to get t he cerebral mechanism and objective assessment criterion of acup unct ure anest hesia.12volunteers were enrolled and each one received pain stimulation and attended two group experiment s ,i.e.,one was t ranscutaneo us elect rical stimulation on Hegu acupoint (TEAS ),and t he ot her was cont rol group wit h no stimulation.The EEG was recorded and t he spect rum edge frequency (SEF )was ext racted ,when attending visual analogue scale (VAS )test.The SEF in 2creased after pain stimulation ,and t hen it decreased slowly ,but it decreased more quickly and to a larger extent in t he TEAS group.The SEF had t he same change t rend wit h VAS.The st udy primary proved t he efficiency of acup unct ure in pain relief and SEF could be used as an objective assessment criterion of pain perception.

K ey w ords :pain ;acup unct ure ;TEAS ;SEF ;VAS

疼痛是一个极为古老的问题,在人类的历史长河中,疼痛始终伴随着岁月,与人类的存在和发展密

切相关.疼痛又是一个极其复杂的生理病理现象,现代医学对其机制的阐述还没有令人满意的答案.