来氟米特(leflunomide)的作用机制和临床应用

来氟米特(leflunomide)的作用机制和临床应用

作者：王泳

作者单位：南京军区南京总医院,解放军肾脏病研究所,南京,210002

刊名：

肾脏病与透析肾移植杂志

英文刊名：CHINESE JOURNAL OF NEPHROLOGY,DIALYSIS & TRANSPLANTATION

年，卷(期)：2004,13(2)

被引用次数：15次

1.Fairbanks LD;Bogil M;Ruekemann K Importance of ribonucleotide available to proliferating T-lymphocyte from healthy humans:disproportion expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors 1995

2.Davis JP;Cain GA;Pitts WJ The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase[外文期刊] 1996

3.Lucien J;Dias VC;Le Gatt Blood distribution and single-dose pharmacokinetics of leflunomide 1995

4.Xu X;Williams JW;Gong H Two activities of the immunosuppressive metabolite of leflunomide,A77 1726.Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation[外文期刊] 1996

5.Elder RT;Xu X;Williams JM The immunosuppressive metabolite of leflunomide,A771726,affeacts murine T cells through two biochemical mechanisms 1997

6.PaulWE;Seder RA Lymphocyte responses and cytokines[外文期刊] 1994

7.Schmidt A;Schwind B;Gillich M Simultaneous determination of leflunomide and its active metabolite,A771726,in human plasma by high-performance liquid chromatograpb[外文期刊] 2003(4)

8.Siemasko KF;Chong AS;Williams JW Regulation of B cell function by the immunosuppressive agent leflunomide[外文期刊] 1996(4)

9.Hardinger KL;Wang CD;Schnitzler MA Prospective,pilot,openlable,short term study of conversion to leflunomide reverse chronic renal allograft dysfunction[外文期刊] 2002

10.Fei xiao;Anita Chong;Jikun Shen Pharmacologically induced regression of chrouic transplant rejection[外文期刊] 1995(10)

11.Xiao F;Chong ASF;Foster P Leflunomide controls rejection in hamster to rat cardiac xenografts[外文期刊] 1994

12.Xiao F;Chong ASF;Shen J Pharmacologically induced regression of chronic trabsplant rejection[外文期刊] 1995

13.Williams JW;Mital D;Chong A Experience with leflunomide in solid organ transplantation[外文期刊] 2002(3)

14.Remer CF;Weisman MH;Wallace DJ Benefits of leflunomide in systemic lupus erythematosus:a pilot observational study[外文期刊] 2001(07)

15.Morris RE;Huang X;Cao W Leflunomide (HWA 486) and its analog suppress T-and B-cell proliferation in vitro,acute rejection,ongoing rejection,and antidonor antibody synthesis in mouse,rat,and cynomolgus monkey transplant recipients as well as arterial intimal thickening after bal 1995

16.Fox RL;Mukhopadhyay A;Aggarwal BB Mechanism of action of leflunomide in rheumatoid arthritis

1998(ZK)

17.Siemasko KF;Chong ASF;Williams JW Regulation of B cell function by the immunosuppressive agents leflunomide[外文期刊] 1996(04)

18.Bartlett RR;Vrendel S;Zielinski T Leflunomide,an immunorestoring drug for the therapy of autoimmune disorders,especially rheumatoid arthritis 1996

19.Wallace DJ Management of lupus erythematosus:recent insights[外文期刊] 2002(03)

20.Burner D;Begue-Pastor N;Benavent S The active metabolite of leflunomide,A77 1726,inhibits the production of prostaglandin E2,matrix metalloproteinase 1 and interleukin 6 inhuman fibroblast-like synoviocytes[外文期刊] 2003(01)

21.Strand V;Cohen S;Schiff M Treatmentofactiverheumatoidarthritiswithleflunomidecomparedwithplaceboandmethotresate[外文期刊] 1999(21)

22.Smolen JS;Kalden JR;Scott DL Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis:a double-blind,randomized,multicentre trial[外文期刊] 1999

23.Krane SM;Golding SR;Dayer Jm Interactions among lymphocytes,monocytes and other cells in rheumatoid synovium 1982

24.Harris ED Ensymes responsible for joint destruetion 1997

25.Simon AK;Eiplt E;Sieper J Divergent T-cell cytokine patterns in inflammatory arthritis 1994

26.Waldman WJ;Knight DA;Blinder L Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide[外文期刊] 2000(5-6)

27.Petya Dimitrova;Alla Skapenko;Matthias L Restriction of de novo pyrimidine biosynthesis inhibits Thl cell activation and promotes Th2 Cell differentiation[外文期刊] 2002(06)

28.Manna SK;Aggarwal BB Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-B activation and gene expression[外文期刊] 1999

29.Verma IM;tevenson SJK;Schwarz EM Rel/NF-κB/IκB family:intimate tales of association and dissociation 1995

30.Siebenlist U;Franzo G;Brown K Structure,regulation and function of NF-κB[外文期刊] 1994

31.Williamson RA;Yea CM;Robson PA Dihydroorotate dehydrogenase is a high affinity binding protein

for A771726 and mediator of a range of biological effects of the immunomodulatory compound[外文期刊] 1995(38)

1.徐爱华.王随亮来氟米特治疗难治性肾病综合征临床观察[期刊论文]-中国社区医师（医学专业） 2010(5)

2.程娟.李俊.宋珏.郑世瑞.李浩.孔一帆A771726在大鼠体内肝肠循环的研究[期刊论文]-安徽医科大学学报

2010(3)

3.张明.王永生.谷红霞.高鑫来氟米特联合泼尼松治疗难治性肾病综合征58例分析[期刊论文]-中国误诊学杂志