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Drugmakers have two basic combinatorial techniques at their disposal.The first,known as parallel synthesis,was invented in the mid 1980s by H·Mario Geysen,now at Glaxo Wellcome.He initially used parallel synthesis as a quick way to identify which small segment of any given large protein bound to an antibody.Geysen generated a variety of short protein fragments,or peptides,by combining multiple amino acids (the building blocks of peptides and proteins) in different permutations.By performing dozens or sometimes hundreds of reactions at the same time and then testing to see whether the resulting peptides would bind to the particular antibody of interest,he rapidly found the active peptides from a large universe of possible molecules.
翻译
Baidu Nhomakorabea
He initially used parallel synthesis as a quick way to identify which small segment of any given large protein bound to an antibody.
翻译
Geysen generated a variety of short protein fragments,or peptides,by combining multiple amino acids (the building blocks of peptides and proteins) in different permutations.
翻译
By performing dozens or sometimes hundreds of reactions at the same time and then testing to see whether the resulting peptides would bind to the particular antibody of interest,he rapidly found the active peptides from a large universe of possible molecules.
翻译
Drugmakers have two basic combinatorial techniques at their disposal.The irst,known as parallel synthesis,was invented in the mid 1980s by H·Mario Geysen,now at Glaxo Wellcome.
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