固有免疫细胞及功能(英文)PPT课件

1. phagocytes
Mononuclear phagocyte system
neutrophils
monocyte
macrophage microglial cells, Kupffer,Osteoclast
Macrophage
Long-lived( up to several months)
Large amount of azurophil granule and neutrophil granule in the cytoplasm
MHC-I and receptor of adhension molecules
Phagocytes
Biological functions
surface receptors of phagocytes
Mannitol, fucose, phosphatide receptor CR3, CR4 , CD14 C3bR FcγR Toll-like receptor scavenger
Recognized molecules
Corresponding carbohydrate and phosphatide LPS Antigens entrapped by C3b Antigens specially bound by IgG PAMP
Cells in innate immunity and their functions
一. Tissue,cells and molecules of the innate immune system
二.Phases of innate immune responses 三.Characteristics of innate immune response
Phagocytes Biological functions
Antimicrobial and cytotoxic activity
Oxygen-dependent, Oxygen-independent
Secretion of factors
Cytokines, Inflammantory mediators
Antigen presentation
Intrinsic, Extrinsic
Anti-tumour
Antimicrobial and cytotoxic activity
Oxygen-dependent killing mechanisms
Reactive oxygen intermediates(ROIs) Neutrophil myeloperoxidase(MPO) Reactive nitrogen intermediates(RNIs)
一. Tissue barriers and their effection
（一）The skin and mucosal surfaces provide protective barriers against infection
Physical barriers: epithelial, cilia, mucus Chemical barriers: lactic acid, unsaturated fatty acid, gastric acid Biological barriers: microorganisms
Large, pleomorphism and rich in lysosomes in the cytoplasm.
MHC-I/II and many adhension molecules
Many receptors
Neutrophil
Short-lived
Small and round
Large quantities, replaced rapidly
Acquired Immunity Adaptive Immunity Specific Immunity
Species development, formed evolutionally Possess from the time of birth，react rapidly
Non-specific anti-infection immunity, also involved in specific immunity
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（二） Blood-brain barrier （三） blood –fetus barrier
二. Cells involved in innate immunity and their functions
➢ Phagocute ➢ Natural killer cells ➢ T cells ➢ NKT cells ➢ B1 cells
Oxygen-dependent killing mechanisms
acid pH, lysozyme , lactoferrin, cationic protein, elastase
2021/3/9
授课：XXX
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Secretion of factors
Released in appropriate or large quantities Cytokines：TNF-, IL-1, IL-6, IL-8, IL-12, MCP-1 Inflammation mediators：prostaglandin E, LTB4, PAF, phosphatidase, peroxidate Local inflammatory reaction（TNF-、IL-1、 LTB4） Fever and acute phase reaction（CRP、MBL） Immunoregulation（IL-1、IL-6、IL-12）
and its relationship with adaptive immune response
Section I Tissue,cells and molecules of the innate immune system
Innate Immunity Native Immunity Nonspecific Immunity