不同来源间充质干细胞标志物汇总(全)
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不同来源间充质干细胞标志物汇总(全)
(图片来源网络)
间充质干细胞(mesenchymal stem cells,MSC)是一种源于中胚层的早期干细胞,具有多向分化潜能,特定的条件下可分化为骨细胞、软骨细胞和神经细胞等,支持造血,具备低免疫原性和免疫调节活性,具有广泛的科研和临床应用价值。主要存在于结缔组织和器官间质中,以骨髓中含量最为丰富,少量存在于血液及其他组织中。
近年来随着基础科研和临床研究的不断深入,MSC在医学领域的应用价值也得到了极大肯定,但仍然存在一些问题,如:缺少特异性表面标志物,鉴定困难;多次传代后分化能力不能保留;诱导分化调控机制尚不明确等,都是有待于进一步研究和讨论的。MSC主要关键基因和表面分子包括CD73、CD90、CD105,表达极少或无表达CD11b、CD19、CD34、CD45和HLA-DR,其中不同来源之间的MSC标志物存有一定差异性,这里列出来供大家参考。
外周血(Peripheral derived blood)来源[1]
阳性:CD105, CD90, CD73, CD73, CD44, CD90.1, CD29, CD105, CD106, CD140α
阴性:CD34, CD19, CD11b
骨髓(Bone marrow)来源[2]
阳性:CD105, CD13, CD140b, CD147, CD151, CD276, CD29, CD44, CD47, CD59, CD73, CD81, CD90, CD98
阴性:CD14, CD31, CD34, CD45
皮肤(Skin)/包皮(foreskin)来源[3]
阳性:CD29, CD44, CD73, CD90, CD105, vimentin
阴性:CD34, CD45, HLADR
脂肪(Adipose)来源[4]
阳性:CD9, CD29, CD44, CD54, CD73, CD90, CD105, CD106, CD146, CD166
阴性:CD14, CD31, CD34, CD45, CD133, CD144, HLA-DR,
STRO-1
尿液(Urine)来源[5,6]
阳性:CD29, CD44, CD54, CD73, CD90, CD105, CD166,STRO-1, Oct-4, Klf-4, Sox-17, vimentin
阴性:CD41, HLA-DR
心(Heart)来源[7]
阳性:CD44, CD105, CD29, CD90
阴性:CD14, CD45, CD34, CD31
牙(Dental)来源[8,9]
阳性:CD13, CD29, CD44, CD49, CD73, CD90, CD146, STRO-1, Oct-3/4, NANOG, SSEA-3
阴性:CD14, CD31, CD34, CD45, HLADR
骨骼肌(Skeletal muscle)来源[10]
阳性:CD29, CD44, CD49E, CD56, CD73, CD90, CD105, HLA-I
阴性:CD34, CD45
胰腺(Pancreas)来源[11]
阳性:CD105, CD90, CD73, CD44, CD29, CD13, nestin,vimentin, CD146, NG2, α-SMA, PDGF-R β
阴性:CD31, CD34, and CD45, CK19, CA19.9
肺(Lung)来源[12]
阳性:CD73, CD90, and CD105, vimentin, prolyl-4- hydroxylase
阴性:CD14, CD34, CD45
胚胎干细胞(ESC)[13]
阳性:CD29, CD44, CD73, CD105, SSEA-4
阴性:CD34, CD45, HLADR
诱导多能干细胞(iPSC)[14]
阳性:CD29, CD44, CD166, CD73, CD105, KDR, MSX2
阴性:CD34, CD45, HLADR
沃顿果冻(Wharton jelly)来源[15]
阳性:CD44, CD73, CD90, CD105, CD166
阴性:CD14, CD34, CD45
胎盘(Placenta)来源[16,17]
阳性:CD105, CD73, CD90c-kit, Thy-1, Oct-4, SOX2, hTERT, SSEA-1,3,4, TRA-1
阴性:CD34, CD45, CD14 or CD11b, CD19, HLA-DR
脐带(Umbilical cord)来源[18]
阳性:CD73, CD90, CD105, Oct-4, Nanog, ABCG2, Sox-2,Nestin
阴性:CD34, CD45, CD19, HLA-DR
绒毛(Chorionic villi)来源[19]
阳性:CD44, CD117, CD105, α-SMA, CD49, CD146, CD106, CD166, Stro-1, vWF
阴性:CD34, CD45, CD19, HLA-DR
绒毛膜(Chorionic membrane)来源[20]
阳性:CD44, CD49, CD56, CD73, CD90, CD105
阴性:CD45, CD34, CD14, CD31, EPCAM, HLA-DR
脐带血(Cord blood)来源[17]
阳性:CD29, CD 73, CD105, CD44, Oct-4, Sox-1, Sox2, NANOG, ABCG2, Nestin
阴性:CD34, CD45
子宫内膜(子宫内膜)来源[21]
阳性:CD73, CD90, CD105, CD166, HLA-ABC, Oct-4
阴性:CD14, CD34, CD45, HLA-DR
羊膜(Amniotic membrane)来源[22,23]
阳性:CD73, CD90, CD105, Oct-4, SSEA-4, Tra-1
阴性:CD11b, CD14, CD19, CD79α, CD34, CD45, HLA-DR
羊水(Amniotic fluid)来源[24]
阳性:CD73, CD90, CD105, CD166, MHC class I, Oct-4, EA- 1