医学免疫学英语试题

ⅠChoose one which is the best answer in each question(40 × 1 point = 40 )

1、Immunological unresponsiveness to self antigens is called: ( A)

A Tolerance

B Tolerogen

C Memory

D Acquired immunity

2、The signal transduction molecules associated with BCR are (B )

A、CD21 and CD81、

B、Igαnd IgβCD79a,b

C、IgD and IgM、

D、ITAMs and ITIMs、

3、T cells are MHC-restricted in their ability to respond to antigen because

(D )

A、all antigen must be processed and presented to activate lymphocytes、

B、during an infection, all cells in the body present antigen on MHC Class I、

C、MHC binds antigen more specifically than TCR does、

D、TCR must recognize both antigen and MHC molecules、

4、An antibody Fab contains ( A B)

A、plementarity determining regions、

B、H and L chain variable regions、

C、one antigen binding region、

D、one H-L interchain disulfide bond、

5 Positive selection in the thymus is mediated by: ( A )

A Thymic epithelial cells、

B Macrophages、

C Dendritic cells、

D B-cells、

6、Type Ⅳ hypersentivity is often referred to as: ( B )

A、Immediate hypersensitivity

B、Delayed hypersensitivity

C、Cytotoxic hypersensitivity

D、Allergic hypersensitivity

7、Type Ⅱhypersentivity is often referred to as: ( C )

A、Immediate hypersensitivity

B、Delayed hypersensitivity

C、Cytotoxic hypersensitivity

D、Allergic hypersensitivity

8、Naive B cell expresses ( C )

A、IgA alone

B、IgA and IgG C IgM +IgD D、IgE and Ig

9、T cell-derived cytokines ( D )

A、are antigen-specific products of T cell activation

B、are stored in the resting T cell and released on activation

C、are MHC-restricted in their effects

D、influence the class of antibodies produced by B cell

10. Neutrophils are attracted to an infected area by ( C )

A. IgM B、C1 C、C5a D、C8

11. plement lyses cells by ( C )

A. enzymatic digestion of the cell membrane

B. activation of adenylate cyclase

C. insertion of plement proteins into the cell membrane

D. inhibition of elongation factor 2

12、CD8 is a marker of ( C)

A. B cells B、Helper - T cells C、cytotoxic T cell D、Mφ

13、MHC class Ⅱ molecules are found on (B )

A. Virtually all cells in the body B、 B cells, DC and Mφ

C、Virtually all nucleated cells in the body

D、Only on virally-infected cells、

14、All of following cytokines are secreted by Th2 cells except (B )

A. IL-4 B、IFN-γ C、IL-5 D、IL-6

15、Which of the following is NOT true of CD4+ and CD8+ cell markers? ( D )

A、These are both surface glycoproteins expressed on T-cells、

B、These serve to distinguish different types of T-cells, e、g、, helper, suppressor and cytotoxic, from each other、

C、These are not found associated with immunoglobulins、

D、Both of the markers are present on ALL T-cells、

16、 Cells bearing MHC class I plus peptide are targets for specific: ( B )

A B-cells、

B Cytotoxic T-cells、

C Th1 cells、

D Th2 cells、

17、Dendritic cells are characterized by: ( D )

A the presence of major basic protein

B expression of CD3

C expression of IgM molecules

D their interface between the innate and adaptive immune system

18、Which of the following uniquely distinguishes the T-cell receptor (TCR)

from an antibody? ( A )

A、The TCR can bind an antigen fragment only in a trimolecular plex with either the class I or class II surface proteins of the major histopatibility plex

B、The TCR can function as a cell surface antigen receptor

C、The TCR is posed of two different types of polypeptide chains

D、The TCR is capable of participating in a cytotoxic reaction、

19、A critical property of an antigen is ( A )

A、Its ability to stimulate an immune response

B、a unique topological feature called an paratope

C、not a unique topological feature called an antigenic determinant

D、the size of which is relatively small

20、Opsonization of bacteria occurs through coating bacteria just with: ( A )

A C3b

B C8

C Membrane attack plex

D IgM

21、 The following is characteristic of B- but not T-cells: ( D )

A Class I MHC、

B CD3、

C HIV virus receptor、

D Surface immunoglobulin、

22.Which of the following molecules is expressed on the surface of mature CD4+T cells? ( C )

A、B cell receptor

B、CD1d

C、CD3

D、CD8

23. The thymus is the site of initial differentiation for ( D )

A. B cells B、Erythrocytes C、Hematopietic stem cells D、T cells

24、The membrane attack plex consists of: ( C )

A OH

B C3b3b,Bb

C C5b,6,7,8,9

D Properdin

25、Type Ⅰhypersentivity is often referred to as: (A )

A、Immediate hypersensitivity

B、Delayed hypersensitivity

C、Cytotoxic hypersensitivity

D、Immune plex hypersensitivity

26、Type Ⅲ hypersentivity is often referred to as: ( D)

A、Immediate hypersensitivity

B、Delayed hypersensitivity

C、Cytotoxic hypersensitivity

D、Immune plex hypersensitivity

27、The typeⅠhypersentivity is mediated by: ( D )

A、IgA

B、IgD

C、IgG

D、IgE

28、The cytokine which is most involved in the class switch to IgE production is: ( D )

A、IL-1

B、IL-2

C、TGF beta

D、IL-4

29、Which type hypersensitivity is related to the mechanism of acute Arthus reaction: ( C )

A、Type Ⅰhypersentivity

B、Type Ⅱhypersentivity

C、Type Ⅲ hypersentivity

D、Type Ⅳ hypersentivity

30、 T-cell CD40L provides a costimulatory signal to B-cells by ligating: ( A )

A CD40

B MH

C class II C CD28

D CD19

31、Which immunoglobulin can be transported through the placenta? ( A )

A、IgG

B、IgM

C、Secretory IgA

D、IgE

32、Which immunoglobulin is the most one in the blood? ( A )

A、IgG

B、IgM

C、Secretory IgA

D、IgE

33、Which immunoglobulin can mediate the immediate hypersensitivity? ( D )

A、IgG

B、IgM

C、Secretory IgA

D、IgE

34、Molecules directly involved in NK cell mediated killing include: ( B )

A nitric oxide

B granzyme

C plement

D IFN-γ

35、Immune plexes consist of ( C )

A、antibody plus plement

B、basophil plus plement

C、antigen plus antibody

D、antigen plus plement

36、 The main costimulatory signal for activation of resting T-cells is provided by ligation of: ( A )

A CD28

B Surface Ig

C LFA-1

D VLA-4

37、 The T-cell receptor antigen recognition signal is transduced by: ( E )

A The TCR alpha chain、

B The TCR beta chain、 D CD2、 E CD3、

38、 The T-cell ligand binding B7 on a professional antigen-presenting cell is: A

A CD28

B CD2

C LFA-1

D ICAM-1

39、 Secondary antibody responses are better because: ( C)

A They provide defense against unrelated antigens

B The antibody can be made by both T and B cells

C They are stronger and faster

D They do not require T-cell help

40、 Which cell type produces antibodies?: ( D )

A Macrophages

B T-lymphocytes

C NK

D Plasma cells II、Indicate whether each of the following statements is true or false、(10×2 points =20 )

1、A hapten can stimulate antibody formation but cannot bine with antibody molecules、( F)

2、Booster shots are required because repeated exposure to an antigen builds a stronger immune response、( T)

3、The Igα/Igβ heterodimer and CD3 serv e analogous functions in the B-cell receptor and T-cell receptor, respectively、( T )

4、Antigen-presenting cells express both class I and class II MHC molecules on their membranes、( T )

5、Babies can acquire IgE-mediated allergies by passive transfer of maternal antibody、( F )

6、Both CTLs and NK cells release perforin after interacting with target cells、( T )

7、Target cell lysis and destruction can be achieved by perforin released from antigen-specific cytotoxic T-cells ( T )

8、The immune response is mediated via the humoral and/or cellular arms of the immune system ( T )

9、Immediate type hypersensitivity is mediated by IgM、( F )

10、All cytokine-binding receptors cintain two or three subunits、( T )

Ⅲ Answer the following questions in brief (10×4points =40 )

https://www.360docs.net/doc/a74954669.html, the three types of professional APCs, and give one example of

nonprofessional APCs、B M DC endothelial cell

2.Summarize the four major functions of plement system ①lysis of cells,

bacteria and viruses ②opsonization to enhance phagocytosis ③clearance of immune plexes ④stimulation of inflammation

3、List the classical Class I and Class II gene loci for humans

4、What dose " MHC restriction" mean?HLA-A,B,C HLA-DPDRDQ

5、To activate T cells, two molecules must be recognized on the

antigen-presenting cells, what are they? Peptide-MHC

6、pare the primary and secondary responses from the following points of view: (a) time for antibody to appear (b) quantity of antibody produced (c) class of antibody produced (d) duration of antibody production、

7、pare Class I and Class II MHC proteins from the following points of view:

(a) types of cells on which they are located (b) role in antigen recognition by CD4+ and CD8+ T cells、

8. Helper T cells can be divided into two subsets based on their lymphokine

secretion profile、Explain、

9. What are the main functions of macrophages?

10. Please draw a schematic diagram of a typical IgG molecule and label each

part of the chains、