药用植物内生真菌及活性物质多样性研究进展_孙剑秋

西北植物学报,2006,26(7):1505-1519

Acta Bot.Boreal.-Occident.Sin.

文章编号:1000-4025(2006)07-1505-15＊

药用植物内生真菌及活性物质多样性研究进展

孙剑秋1,2,3,郭良栋2＊,臧　威1,3,迟德富1

(1东北林业大学林学院,哈尔滨150040;2中国科学院微生物研究所真菌地衣系统学重点实验室,北京100080;3齐齐哈尔大

学生命科学与工程学院,齐齐哈尔161006)

摘　要:药用植物具有丰富的物种多样性,是人类生存与发展的重要自然资源。内生真菌广泛存在于健康植物组

织内部,是植物微生态系统的重要组成部分,各种药用植物中蕴藏着非常丰富的内生真菌。通过与药用植物的“协

同进化”,某些内生真菌具有了产生与宿主植物相同或相似的生物活性物质的能力。内生真菌产生的各种活性物

质,在生物制药、农业生产、工业发酵等方面都表现出美好的应用前景,受到世界各国专家的广泛关注。利用内生

真菌发酵实现生物活性物质的工业化生产,可以提高产量、降低产品成本,满足人们日益增长的需求;同时有利于

珍稀、濒危药用植物资源的保护,对减少野生药用植物多样性的破坏具有重要意义。本文从药用植物内生真菌物

种多样性与产生生物活性物质多样性等方面总结近年最新的研究进展,提出了内生真菌及活性物质研究的未来发

展方向。

关键词:药用植物;内生真菌;生物活性物质;协同进化

中图分类号:Q949.95文献标识码:A

Research Advances in the Diversities of Endophytic Fungi in

Medicinal Plants and Their Bioactive Ingredients

SUN Jian-qiu1,2,3,G UO Liang-dong2＊,ZANG Wei1,3,C HI De-fu1

(1College of Forestry,Northeast Fores try University,H arbin150040;2S ystematic M ycology and Lichenology Laboratory,In sti-

tute of M icrobiology,Chinese Academy of S ciences,Beijing100080;3College of Life Science and Engineering,Qiqih ar University,

Qiqih ar161006)

A bstract:Medicinal plants,w hich are of rich species diversity,a re im po rtant na tural reso urces for human e xistence and develo pment.Endo phy tic fungi,w idely existing inside the tissues of healthy plants,are im-po rtant com po nents o f plant micro-ecosy stems and various medicinal plants are rich in endo phytic fungi. Co-evolving w ith medicinal plants,some endophy tic fung i have developed the abilities to produce same o r similar bioactive substances as or to w hat their host plants produce.V ario us bioactive substances that endo-phytic fung i have show ed a bright prospect in biological pharmaceutical pro duction,agricultural produc-tion,industrial fermentatio n thereby attracting ex tensive interest from ex perts of various countries in the w orld.The industrial productio ns of bioactive substances that m ake use o f endophy tic fungi are capable of increasing their yields and low ering their pro ductive co sts and thus conducive to satisfying people's ever-in-creasing dem ands.In the meantime,it is co nducive to the co nserv ation of precious and endangerd medicinal plants and of g reat impo rtance in avoiding the damage to the diversity of w ild m edicinal plants.The paper summa rizes la test research advances in terms of the diversity of endophy tic fungi and their bioactive sub-＊收稿日期:2006-03-28;修改稿收到日期:2006-05-19

基金项目:国家自然科学基金(30370006,30230020)

作者简介:孙剑秋(1969-),男(汉族),黑龙江德都人,博士,副教授,硕士研究生导师,主要从事微生物学方面的科研与教学工作。

＊通讯联系人。Correspondence to:GUO Liang-dong.E-m ail:gu old@