酒精滥用与成瘾中枢神经递质的研究进展

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本项目受国家自然科学基金(30570653)、国家重大基础研究发展计划(973)项目(2003CB515400)和教育部985项目北京大学天然药物及仿生药物国家重点实验室资助

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[综述]

酒精滥用与成瘾中枢神经递质的研究进展

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陈 锋1

A ndre w J La w rence 1

梁建辉

2**

1

(M elbourne 大学H o w ard F lorey 研究所,V i c t o ria ,3010)

2

(北京大学中国药物依赖性研究所,北京,100083)

酒精滥用及其成瘾是一种失控且紊乱的饮酒行为,被定义为一种病理状态行为综合征。酒精成瘾患者除了机体出现对酒精产生耐受,中断饮酒后出

现戒断症状以及各种并发症外,还突出表现为强迫性觅酒行为,对酒的强烈渴求(crav i n g)和对酒的反复滥用,并且这些行为特征即使在断酒数年后也可

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recomb i nan t adenov iruses on mo rph i ne phy si ca l dependence i n rats [J].Eur J N eurosc ,i 2004,19:221-226[20]Fu jio M,N akagaw a T,Sek i ya Y,

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i nto t he nucleus accu m bens shell

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2744-2754[21]M ao J ,Sung B ,

Ji RR ,

et a.l Chronic m orphi ne induces downregu l ation of spi na l g l uta m a te transpo rters :

i

m p licati ons in m orph i ne to l e rance and abnor m a l pa i n sens itiv ity [J].J N eu rosc,i 2002,22:8312-8323

[22]L i m G,W ang S ,M ao J .cAM P and pro tein kinase :a contr i bute to the downregu lati on o f spina l g luta m ate transpo rters after

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[23]Suzuk iM,N ar itaM,N ar itaM,et a.l Chron i c m orph i ne trea t m ent i ncreases t he expression o f v esi cular g l u ta m ate transporter 1in

the m ouse spina l cord [J].Eur J Phar m aco ,l 2006,535:166-168

收稿日期:2006-06-06 修回日期:2006-07-20