DNA实验-免疫细胞表面抗原分子CD家族对照表(CD1-CD24

免疫细胞表面抗原分子CD家族对照表(CD1-CD247)

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Note: no information is available on CDw145, CD181, CD182, CD185-194, CD196-199, CD211, CD214-216, CD218-220, CD237

Backgro und

CD: cluster designation of monoclonal antibodies (clusters of differentiation)

Desig nated at the 1st to 7 th Workshops on Intern ati onal Huma n Leukocyte

Differen tiati on An tige ns

The last con fere nee was in 2000. The n ext con fere nee is in 2004.

HLDA Workshops are the primary mecha nism to characterize leukocyte surface

an tige nic molecules and epies; erythroid an tige ns are now in cluded

For 1st to 6th workshops, an tibodies were submitted to the orga nizing laboratory,

coded and sent to participati ng laboratories for testi ng aga inst various cell types. For the 7th workshop, a CD designation could be established for a molecule if its gene has been cloned and at least one specific monoclonal antibody had been studied in the Workshop

Interpretation should be based on cellular distribution of staining, proportion of

positively stained cells, staining intensity and cutoff levels.

CD1

Family of non-polymorphic MHC class I-like glycoprote ins

Also member of immu no globulin superfamily

On chromosome 1q22-23 (not MHC lin ked)

Has 5 differe nt subsets, all non covale ntly associated with 12 kd beta 2 microglobuli n

Fun cti on: restrict T cell resp on ses to certa in an tige ns; may mediate thymic T cell developme nt

Positive stai ning (no rmal): cortical thymocytes (70%), activated T cells, Lan gerha ns cells, interdigitating dendritic cells

Positive sta ining (disease): pre T ALL with cortical thymocyte phe no type; Lan gerha ns cell histiocytosis

Negative stai ning: mature peripheral T cells

CD1a

Positive sta ining (no rmal): Den dritic cells in dermis/epidermis of benign in flammatory skin disorders

Positive stai ning (disease): Lan gerha ns cell histiocytosis (fairly specific), myeloid leukemias, some B cell malig nan cies; den dritic cells in most peripheral cuta neous T cell

lymphomas, AJCP 2001;116:72

Negative stai ning: no rmal B cells, most cuta neous peripheral B cell lymphomas (? reflects replaceme nt of reactive patter n containing den dritic cells with a n eoplastic pattern of B cells)