杀虫剂作用机理分类中文版(IRAC权威图表)

(S) (1R)-cis Cl
C CH CH3 CO2
CN
Cl H
HC
O
H
CH3
H CH3 H
Cl
Cl
C
CH
CO2
CH3
H
C
CN
O
(R) (1S)-cis -
顺式氯氰菊酯 (Alpha-
Cypermethrin)
CN
Cl
CH3 CO2CH
O
C CH
Cl
CH3
(Zeta-cypermethrin) zeta-氯氰菊酯
OCH3 HO
CH3 O O
OCH3
CH3 O O
CH3
(i) R = -CH2CH3 (avermectin B1a)
CH3
H O
O
H OO
OH H
(ii) R = -CH3 (avermectin B1b)
O
CH3
H
OH
阿维菌素
CH3 CH3
H R
(Abamectin)
CH3O O CH3
CH3 O CH3 NH2
Cl
HH
O
N N CH3
N NO2
呋虫胺*
(Dinotefuran)
CH3NH
NO2
CC
CH2 N
H
CH2CH3
Cl NO2 N N CH2 N N H
吡虫啉 (Imidacloprid)
N
烯啶虫胺 (Nitenpyram)
S CN N
N CH2
N Cl 噻虫啉
(Thiacloprid)
CH3 N
O
第2组: g-氨基丁酸（GABA）门控氯离子通道拮抗剂
Cl Cl Cl
Cl Cl
Cl Cl
Cl
氯丹 (Chlordane)
Cl
Cl Cl
Cl Cl
Cl
O SO
O
硫丹 (Endosulfan)
2A 环戊二烯有机氯化合物(Cyclodiene Organochlorines)
CH3CH2SO CN
H2N Cl
N N
Cl
CF3
乙虫腈(Ethiprole)
Cl N CN
F3C
N
O
S
Cl NH2 CF3
氟虫腈(Fipronil)
2B 苯基吡唑类 (Phenylpyrazoles (Fiproles))
第3组: 钠离子通道调控剂 (仅列出该组3A亚类主要代表性化合物)
F3C (Z)-(1R)-cis-
CH3
C CH CH3 CO2CH2
二嗪磷 (Diazinon)
CH3OPSCH3 NH2
久效磷 (Monocrotophos)
Br
OO P OCH2CH3
Cl SCH2CH2CH3
特丁硫磷 (Terbufos)
乐果 (Dimethoate)
甲胺磷 (Methamidophos)
丙溴磷 (Profenofos)
1B 有机磷酸酯类 (Organophosphates)
甲氧滴滴涕 (Methoxychlor)
3B 滴滴涕及甲氧滴滴涕 (DDT, Methoxychlor)
第4组: 烟碱型乙酰胆碱受体（nAChR）激动剂
CH3 CN CN
CH2 N CH3
N Cl
啶虫脒 (Acetamiprid)
H
NO2
N CH3
N
Cl
S
NH
CH2
N
噻虫胺 (Clothianidin)
第1组: 乙酰胆碱酯酶（AChE）抑制剂 (仅列出该组主要代表性化合物)
CH3 CH(CH3)2 OCON S NCH2CH2CO2CH2CH3
O CH3
CH3
CH3S
CH3 C CH CH3
NOCONHCH3
丙硫克百威 (Benfuracarb)
涕灭威 (Aldicarb)
OCONHCH3
OCONHCH3 O CH3 CH3
各化学结构转载于农药手册并取得英国作物保护委员会许可
杀虫剂作用机制分类
第15组: 几丁质生物合成抑制剂，0型
F FF
F OO
NN HH
F F
Cl F
F
双三氟虫脲
(Bistrifluron) Cl
F
Cl Cl
CONHCONH F
O
CF3
N
Cl
氟啶脲 (Chlorfluazuron)
Cl
F
NHCONHCO
克百威 (Carbofuran)
甲萘威 (Carbaryl)
CH3 OCO N S N[(CH2)3CH3]2
O CH3
CH3 丁硫克百威 (Carbosulfan)
O CH3NHC O
CH3 CHCH2CH3
仲丁威 (Fenobucarb)
O CH3NH C O
CH3
CH3
SCH3
甲硫威
CH3NHCO2N
SCH3 C
CH3
灭多威 (Methomyl)
CH3
CH3NCO2N C
S
SCH3
SCH3
CH3NCO2N C
CH3
硫双威
(Methiocarb) (CH3)2NCOC NOCONHCH3 (Thiodicarb)
SCH3
杀线威
(Oxamyl)
(CH3)3C
N N CON(CH3)2
N
SCH2CO2C2H5
O
CH3
H OH
密灭汀/弥拜菌素*
(Milbemectin)
6 阿维菌素类，米尔贝霉素类 (Avermectins, Milbemycins)
第7组: 仿生保幼激素
CH3
CH3 H CH3
CH CH3
CH2 CH2
CH CH2
C CH2
C
C
C
HH
CO2CH2CH3
烯虫乙酯 (Hydroprene)
CH3
Br
C CH
Br
H
CH3 CO2
CN C
HH
O
CH3
溴氰菊酯 (Deltamethrin)
OO
CN
C
C
O
Cl
HH
CH(CH3)2
顺式氰戊菊酯 (Esfenvalerate)
CH3CH2O
O
CH3 C CH2OCH2 CH3
醚菊酯 (Etofenprox)
CH3 C
R
OH
H
CO
CH
H
CH3 CH3
CH3
F
除虫脲 (Diflubenzuron)
CH2 C NO
CF3
F NHCONHCO
F
Cl O
F
NHCONHCO
F
F
氟虫脲 (Flufenoxuron)
Cl CF3CHFCF2O
Cl
F
CF3OCHFCF2O
NHCONHCO
F
F
NHCONHCO F
Cl
氟酰脲
Cl
(Novaluron) F
Cl
F
NHCONHCO
H
CH2 C
CH
O
R1
R = -CH3 (chrysanthemates) or -CO2CH3 (pyrethrates) R1 = -CH=CH2 (pyrethrin) or -CH3 (cinerin) or -CH2CH3 (jasmolin)
F3C
(S) (Z)-(1R)-cis -
C CH CH3 CO2
唑蚜威 (Triazamate)
1A 氨基甲酸酯类 (Carbamates)
O
CH3SP NHCOCH3 OCH3
乙酰甲胺磷 (Acephate)
S
Cl
N OP(OCH2CH3)2
S (CH3O)2PS CHCH2CO2CH2CH3
O2N
S OP(OCH3)2
Cl
Cl
毒死蜱 (Chlorpyrifos)
N NO2
N
CH2 S
Cl N 噻虫嗪
(Thiamethoxam)
4A 新烟碱类 (Neonicotinoids)
N
CH3
N
H
烟碱 (Nicotine)
4B 烟碱 (Nicotine)
第5组: 烟碱型乙酰胆碱受体（nAChR）别构调节剂
第6组: 氯离子通道激动剂
多杀霉素 (Spinosad)
(CH3)2N CH3 O O
第8组: 其它非特异（多位点）抑制剂
CH3Br
溴甲烷 (Methyl bromide) 8A 卤化烷类 (Alkyl halides)
Cl3C NO2
氯化苦 (Chloropicrin)
8B 氯化苦 (Chloropicrin)
O FSF
O
硫酰氟 (Sulfuryl fluoride)
8C 硫酰氟 (Sulfuryl fluoride)
第10组: 螨虫生长抑制剂
Cl NN
NN Cl
四螨嗪 (Clofentezine)
O
S
O
Cl
NC
NH
CH3
噻螨酮 (Hexythiazox)
10A 四螨嗪及噻螨酮 (Clofentezine, Hexythiazox)
第11组: 干扰昆虫中肠肠膜功能的微生物及其衍生毒素
O
O
- O 3+ O - O Sb O -
Cl
H
H
CH3
Cl
H CH3 H
C CH
CO2C H2
F3C
CH3
CH3
(Z)-(1S)-ci s-
联苯菊酯 (Bifenthrin)
Cl
CN
C CH
CH3 CO2CH
O
Cl
CH3
F
氟氯氰菊酯 (Cyfluthrin)
Cl
CH3
CN
C CH
CO2CH
O
Cl
CH3
氯氰菊酯 (Cypermethrin)
O
3+ O -
O
Sb O-
.2K+ .3H2O
O
O
酒石酸锑钾*
(Tartar emetic)
8E 酒石酸锑钾 (Tartar emetic)
F N
O F
O CH2CH3 C(CH3)3
乙螨唑 (Etoxazole)
10B 乙螨唑 (Etoxazole)
(B.t.
Israelensis) 苏云金杆菌 以色列亚种 (B.
CH3
CO2CH2C CH
H CC
CC H
CH3
CH CH2 H CH2 CH2
CH CH2
CH3
烯虫炔酯 (Kinoprene)
OCH3 (CH3)2C (CH2)3
CH CH2 H
CH3 C C
H
H CC
CH3 CO2CH(CH3)2
烯虫酯 (Methoprene)
7A 保幼激素类似物 (Juvenile hormone analogues)
CH3
S
N
OP(OCH2CH3)2
N
(CH3)2CH
CO2CH2CH3 马拉硫磷 (Malathion)
O
O
(CH3O)2P O
H (Parathion-methyl)
S
CC
甲基对硫磷
CH3
CONHCH3
(CH3)3CSCH2S P(OCH2CH3)2
(E )
S CH3NHCOCH2SP(OCH3)2
F
F
氟环脲 (Flucycloxuron)
Cl CHF2CF2O
Cl
F NHCONHCO
F
虱螨脲 (Lufenuron)
Cl CF3CHFCF2O
Cl
F
O
FO C
C NH
NH
F
氟苯脲 (Teflubenzuron)
氟铃脲 (Hexaflumuron)
多氟脲 (Noviflumuron)
CF3O
NHCONHCO Cl
H
H
F
CH3
H CH3 H
F
Cl
C CH
CO2CH2
F3C
CH3
F
(Z)-(1R)-ci s-
F CH3
F
F CH3
F
七氟菊酯
(Tefluthrin)
3A 拟除虫菊酯类 及除虫菊素类 (Pyrethroids, Pyrethrins)
Cl
CH
Cl
CCl3
滴滴涕 (DDT)
CH3O
CH CCl3
OCH3
CO2
OCH3
O O
CH3
CH3 O
HO
R H OO
O H
CH3 CH3
O
CH3
H
B1a R = CH3CH2-
OH
甲氨基阿维菌素 B1b R = CH3-
苯甲酸盐
(Emamectin
Benzoate)
CH3
H O
CH3
OO OH H
CH3
OR H
Milbemycin A3: R = -CH3 Milbemycin A4: R = -CH2CH3
Na2 B4 O7 . 10H 2O
硼砂* (Borax)
8D 硼砂 (Borax)
第9组: 选择性同翅目昆虫摄食阻滞剂
N
CH
CH3
N N
NN O H
吡蚜酮
(Pymetrozine)
9B 吡蚜酮
(Pymetrozine)
CF3
CONHCH2CN N
氟啶虫酰胺 (Flonicamid) 9C 氟啶虫酰胺 (Flonicamid)
CH3CH2
O O O
CH3 HH
O
OCH3CH3 OCH3
OCH3
O
HH
H
R
spinosyn A, R = H-
spinosyn D, R = CH3-
- C5 C6, R = H
N
C5= C6, R = CH3
O
OO
O
O
O
O
HH
O
O
HH 5 6 H
O
R
乙基多杀菌素 (Spinetoram)
5 多杀菌素类 (Spinosyns)
杀铃脲 (Triflumuron)
15 苯甲酰脲类 (Benzoylureas)
Insecticide Resistance Action Committee
抗药性治理的关键
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CN
Cl H
C HH
O
CH3
H CH3 H Cl
C CH
CO2
CN
F3C
CH3
C H
O
除虫菊素(Pyrethrins (Pyrethrum))
(R) (Z)-(1S)-cis -
高效氯氟氰菊酯 (Lambda-
cyhalothrin)
(Z)-(1S)-ci sF
F3C Cl C CH CH3 CO2CH2
O
OCH2CH2NHCO2CH2CH3
苯氧威 (Fenoxycarb)
7B 苯氧威 (Fenoxycarb)
NO
O
CH CH2
CH3
O
吡丙醚 (Pyriproxyfen)
7Cபைடு நூலகம்吡丙醚 (Pyriproxyfen)
* 目前为非标准化中文通用名称。同一化合物可能存在不同非标准化中文名称。
亚组使用指南:
• 亚组代表具有相同作用机制而化学结构类别不同的化合物。 • 亚组是用来区分那些可能结合于相同作用靶位的化合物。 • 由于亚组化合物化学结构不同，其产生代谢性交叉抗药性的风险低于那些结构相近的化学同系物。