基因组不稳定性与癌症 ppt
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Mutations in DNA repair genes
The presence of both
CIN and non-CIN forms
of genomic instability
Mutations in DNA mismatch repair genes
MSI
Germline mutation in MYH (DNA base exsicion repair gene)
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1,137 genes 167 of 1,137
848 genes 183 of 848
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1,327 genes
685 genes
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223 genes 79 of which
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356 genes 193 of which
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22Baidu Nhomakorabea
Genomic instability
45
Conclusion and perspectives
Molecular basis
46
Conclusion and perspectives
Molecular basis
47
Conclusion and perspectives
48
GC tranverse to TA
6
In hereditary cancers that are characterized by the presence
of CIN, the genomic instability can also be attributed to
mutations in DNA repair genes.
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Mutations in caretaker genes
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Genomic instability
44
Growth-regulating genes
Growth-regulating genes
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4
5
Mutations in DNA repair genes
The presence of both
CIN and non-CIN forms
of genomic instability
Mutations in DNA mismatch repair genes
MSI
Germline mutation in MYH (DNA base exsicion repair gene)
7
8
9
10
11
12
13
14
15
1,137 genes 167 of 1,137
848 genes 183 of 848
16
1,327 genes
685 genes
17
223 genes 79 of which
18
356 genes 193 of which
19
20
21
22Baidu Nhomakorabea
Genomic instability
45
Conclusion and perspectives
Molecular basis
46
Conclusion and perspectives
Molecular basis
47
Conclusion and perspectives
48
GC tranverse to TA
6
In hereditary cancers that are characterized by the presence
of CIN, the genomic instability can also be attributed to
mutations in DNA repair genes.
23
24
Mutations in caretaker genes
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
Genomic instability
44
Growth-regulating genes
Growth-regulating genes