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2A-HUB monoubiquitinates histone H2A in vivo
Conclusion 1
2A-HUB functions as a transcriptional repressor, and can specifically monoubiquitinate H2A in vitro and in vivo.
Thanks for yf 2A-HUB
nuclear receptor co-repressor 1
NR: nuclear receptors GPS2: G protein pathway suppressor 2 TBL1: transducin beta like 1
N-CoR: nuclear receptor co-repressor 1
Summary
2A-HUB functions as a transcriptional repressor, and can specifically monoubiquitinates H2A in vitro and in vivo. 2A-HUB and N-CoR regulate a subset of chemokine gene expression. H2A ubiquitination mediated by 2A-HUB negatively regulates transcriptional elongation by preventing FACT recruitment.
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Name Email 3/7/2012
H2B ubiquitination mediated by Rad6/Bre1
H2A ubiquitination mediated by PRC1
Knockout Bmi-1 results in significant loss of H2A ubiquitylation and upregulation of Hoxc13 expression, whereas EZH2-mediated H3-K27 methylation is not affected. Our results suggest that EZH2-mediated H3K27 methylation functions upstream of PRC1 and establishes a critical role for Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
ChIP analysis of the endogenous RANTES promoter
ChIP analysis of the endogenous RANTES promoter
Model
Conclusion 3
H2A ubiquitination mediated by 2A-HUB negatively regulates transcriptional elongation by preventing FACT recruitment.
Interaction between NCoR/HDAC1/3 components and 2A-HUB
2A-HUB mediated transcription repression
2A-HUB monoubiquitinates histone H2A in vitro
2A-HUB monoubiquitinates histone H2A in vitro
The recruitment of 2A-HUB and uH2A on the target gene promoters
Conclusion 2
2A-HUB and N-CoR regulate a subset of chemokine gene expression.
Coimmunoprecipitation of Spt16 and H2A/H2B
2A-HUB and N-CoR regulate a subset of chemokine gene expression
2A-HUB and N-CoR regulate a subset of chemokine gene expression
2A-HUB and N-CoR regulate a subset of chemokine gene expression