研究生复试、小组会ppt英文模板

(k=a/q=2U/V)
Stability of Solution of Mathieu Equation
Changing the values of U and V can achieve quality scanning.
方向,覃莉莉,白岗等.四极杆质量分析器的研究现状及进展[J].质谱学报,2005,26(4)
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A journey of a thousand miles begins with a single step Cooperation
Progress
THANKS!
有效区域
Free degree：r/r0 r=1.148r0(Deviation < 1 % )
四Hale Waihona Puke 场作用区域Quadrupole mass analyzer
Mathieu方程 直流分量: u 交流分量 :V cos ωt 场半径: r0 令ξ= 1/2ωt
方向,覃莉莉,白岗等.四极杆质量分析器的研究现状及进展[J].质谱学报,2005,26(4)
Food science and aroma industry
(Research on aroma, Production process control)
Disease diagnosis
(Lung cancer,Rectal cancer,diabetes)
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Ion Source (H O Generator)
黄超. 基于频率扫描的数字化四极杆滤质器的研究[D]. 天津大学, 2007.
Quadrupole ion guide (RF-only ion guide)
2 LINAC 式 1
3
4
1.Guo, et al. A radio frequency signal driver for quadrupole used in desktop orthogonal-injection time-offlight mass spectrometer ☆[J]. Nuclear Instruments & Methods in Physics Research, 2012, 694(6):255-262. 2.3.4.黄正旭.高分辨垂直引入式飞行时间质谱仪原理及设计.[D].广州.中科院广州地球化学研究所，2009
What will happen if K = 0 (u = 0)?
m+1, m+2:pass m:can’t pass
Miller P E. Investigations of the RF-only quadrupole mass analyzer [J]. Dissertations & Theses, 1985.
Next work
Learn to build test platform Parameter estimation of RFQ Refine current design and test platform
Learn how to match electric circuits
Schematic of PTR-MS
Hansel A,et al. Proton-transfer-reaction mass spectrometry (PTR-MS): on-line monitoring of volatile organic compounds at volume mixing ratios of a few pptv[J]. Plasma Sources Science & Technology, 1999, volume 8(2):332-336(5).
Next work
Next work
Learn how to use SIMION
Define the energy, angle, and position of random ions
Define the parameters of the
quadrupole transmission (voltage, physical dimension...)
Parameter estimation and mechanical design of
Quadrupole Design of matching circuit
Low-mass cut-off value (LMCO)
Test and modify
Outline
PTR-MS Quadrupole ion guide
VOCs H3O [VOCsH ] H2O
李建权,沈成银,王鸿梅等.质子转移反应质谱的建立与性能研究[J].分析化学,2008,36(1)
Quadrupole mass analyzer
a. Hyperboloid
b. Cylinder Machining difficulty：a>b Machining accuracy：b>a
PTR-MS
Overview
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细胞
检测器
ATP
质谱图
李建权等.质子转移反应质谱的建立与性能研究[J].分析化学,2008,36(1)
PTR-MS
Development
1966:F.H.Field and M.S.B.Munson developed chemical ionization; 1969:Flowing afterglow and flow drift tube technique (FDT) developed by Ferguson and colleagues ; 1990s:On the basis of SIFT-MS,Innsbruke’s Lindinger team put forward the PTR-MS technology for the first time in combination with chemical ionization theory (1996) and drift tube model (1969).
Improve sensitivity
Transmission efficiency is high Requirement of vacuum degree is low
Quadrupole ion guide (RF-only ion guide)
When u = 0, the mass scan line coincides with the q axis, theoretically, all the ions in the stable region can pass through the quadrupole ion guide device.
Quadrupole mass analyzer
m+1:pass m,m+2:can’t pass
Changing the slope of the quality scan line (K = a/q), that is, changing the u/v value causes the scan line to move down.
PTR-MS
Applications
Air quality testing
(Real-time online quantitative measurements of trace VOCs)
Biological research
(Monitor the response of plant leaf wounds)
Mathieu参数
Quadrupole mass analyzer
The movement of ions in the quadrupole can be described by the solution of the Mathieu equation.
First stable region
Quality scan line:y=kx
Outline
PTR-MS
Quadrupole ion guide Next work
Quadrupole ion guide (RF-only ion guide)
Why do we want to use quadrupole ion guide?
Reduce the loss of ions in the transmission path Reduce the space divergence and energy dispersion of ions
PTR-MS & Quadrupole ion guide
Outline
PTR-MS Quadrupole ion guide
Next work
PTR-MS
Introduction
Overview
Development
Application
Component
Ion Source Drift Tube Quadrupole mass analyzer
1998,the first commercial PTR-MS instrument was produced by IONICON Analytik.
PTR-MS
Development
Multichannel data acquisition
High sensitivity(a few pptv)
In June of 1995, Lindinger: Acetonitrile and benzene in the breath of smokers and non-
smokers investigated by PTR-MS;
In July of 1995, Lindinger: PTR-MS: Online Trace Gas Analysis at ppb Level.
Schematic of PTR-TOF-MS
Blake R S, Whyte C, Hughes C O, et al. Demonstration of proton-transfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds.[J]. Analytical Chemistry, 2004, 76(13):3841-5.
3 +
Structure of Double Hollow Cathode Discharge
伍小梅等.在线检测挥发性有机物的质子转移反应飞行时间质谱仪的研制[J].质谱学报,2015,36(1)
Drift Tube (Proton transfer reaction)
Structure of Drift Tube
Quadrupole ion guide (RF-only ion guide)
Probulems must be solved
Working air pressure of quadrupole ion guide-design
of the vacuum system (selection of pump, Cavity size, opening size...)