陈子江,妇产科学生殖医学主任医师,山东大学讲席教授,国

简历
陈子江，妇产科学/生殖医学主任医师，山东大学讲席教授，国家百千
万人才、“973”项目首席科学家，国家重点研发计划首席专家。

1979
年进入山东医学院临床医学专业，师从我国著名的妇产科专家苏应宽
教授，1989年获医学博士学位，1993年破格晋升为教授。

现任山东大学副校长、齐鲁医学院院长，山东省立医院妇产科主任，
山东大学附属生殖医院首席专家，国家辅助生殖与优生工程技术研究中心主任，教育部生殖内分泌重点实验室主任，山东省生殖健康临床医学研究中心主任。

兼任国务院学位委员会第七届学科评议组成员，国家卫生标准委员会医疗服务标准专业委员会委员，中华医学会妇产科学分会妇科内分泌学组组长，中国医师协会生殖医学专业委员会副主任委员，国际生殖学会联盟（IFFS）常务理事和副秘书长、《中华妇产科学》副总编辑；Human Reproduction Update副主编。

从事妇产科学、生殖医学和医学遗传学领域的临床诊疗与科学研究，先后主持国家重点研发计划、973项目、863计划、国自然等课题多项；获国家级奖励4项，何梁何利科技奖、山东省科学技术最高奖等；在N Engl J Med、Cell、Nat Genet、JCI、PNAS、Am J Hum Genet、Nat Commun、Cell Research等杂志发表SCI论文200余篇。

代表性论著如下（*为通讯作者）
1.Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, …, Richard S. Legro,
and Zi-Jiang Chen*. Frozen versus Fresh Embryo Transfer in Ovulatory Women. N Engl J Med, 2018;
378:126-36.（IF: 72.406）
2.Lei Gao, Keliang Wu, Zhenbo Liu, …, Han Zhao, Jianqiao Liu*, Zi-Jiang Chen*, Jiang Liu*.
Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution. Cell.
2018;173(1):248-259.（IF: 30.41）
3.Zi-Jiang Chen*, Yuhua Shi, , Heping Zhang, Richard S. Legro. Fresh versus Frozen Embryos for
Infertility in Polycystic Ovary Syndrome. N Engl J Med, 2016; 375(6):523-33.（IF: 72.406）
4.Zi-Jiang Chen*, Han Zhao, Lin He, Yuhua Shi, Yingying Qin, Yongyong Shi*, Zhiqiang Li, …,
Jinlong Ma, Yueran Zhao. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011; 43(1): 55–59.
（IF:36.377）
5.Yongyong Shi, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, Zhiqiang Li, …, Lin He*, and
Zi-Jiang Chen*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012; 44(9): 1020-5. （IF:35.209）
6.Xiaoxue Yuan, Tao Hu, Han Zhao, Yuanyuan Huang, Rongcai Ye, Jun Lin, Chuanhai Zhang, Hanlin
Zhang, Gang Wei, Huiqiao Zhou, Meng Dong, Jun Zhao, Haibin Wang, Qingsong Liu, Hyuek Jong Lee, Wanzhu Jin*, and Zi-Jiang Chen*. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc Natl Acad Sci U S A. 2016; 113(10):2708-13. （IF:9.661）
7.Qiliang Xin, Shuangbo Kong, Junhao Yan, Jingtao Qiu, Bo He, Chan Zhou, Zhangli Ni, Haili Bao, Lin
Huang, Jinhua Lu, Guoliang Xia, Xicheng Liu*, Zi-Jiang Chen*, Chao Wang*, and Haibin Wang*.Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 2018; 128(1):175-189. (IF:12.784)
8.Zhibin Hu*, Zheng Li, …, Zi-Jiang Chen*, Jiayin Liu*, Hongbing Shen & Jiahao Sha*. Association
analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun. 2014;
5:3857.（IF:12.124）
9.Keliang Wu, Cuiqing Zhong, Tailai Chen,…, Han Zhao*, Jinsong Li* and Zi-Jiang Chen*.Polar bodies
are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy. Cell Research. 2017; 27(8):1069-1072. （IF:15.606）
10.Tailai Chen, Yuehong Bian, Xiaoman Liu, Shigang Zhao, Keliang Wu, Lei Yan, Mei Li, Zhenglin Yang,
Hongbin Liu, Han Zhao*,Zi-Jiang Chen*. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. Am J Hum Genet. 2017 Sep 7; 101(3):459-465.（IF:10.794）11.Keliang Wu, Tailai Chen, Sexin Huang, Cuiqing Zhong, Junhao Yan, Xiaoyu Zhang, Jinsong Li, Yuan
Gao*, Han Zhao*, Zi-Jiang Chen*. Pre-pronuclear transfer in human embryos. Cell Research.
2017;1-4. （IF:15.606）
12.Han Zhao, Jianfeng Xu, Haobo Zhang, …, Jinlong Ma, S. Lilly Zheng, and Zi-Jiang Chen*. A
Genome-wide Association Study Reveals Variants within the HLA Region Are Associated with Risk for Nonobstructive Azoospermia. Am J Hum Genet. 2012; 90(5): 900-906. （IF:11.202）
13.Cuiqing Zhong, Meiling Zhang, Qi Yin, Han Zhao, Yang Wang, Sexin Huang, Wenrong Tao, Keliang
Wu*, Zi-Jiang Chen*, and Jinsong Li*. Generation of human haploid embryonic stem cells from parthenogenetic embryos obtained by microsurgical removal of male pronucleus. Cell Research. 2016;
26(6):743-6. （IF:15.606）
14.Yingying Qin, Xue Jiao, Joe Leigh Simpson, and Zi-Jiang Chen*. Genetics of primary ovarian
insufficiency: new developments and opportunities. Hum Reprod Update. 2015; 21(6):787-808.
（IF:11.194）
15.Xuan Yao*, Meilign Zhang, …, , Keling Wu, Weiping Li*, Zi-jiang Chen*, Hui Yang*. Efficient
precise targeted integration using Tild-CRISPR. Developmental Cell. 2018. Accepted. (IF:9.174)
16.Yingying Qin, Han Zhao, Jianfeng Xu, Yongyong Shi, Zhiqiang Li, Jie Qiao, Jiayin Liu, Chunrong Qin,
Chune Ren, Jie Li, Shiling Chen, Yunxia Cao, China POF Study Group, Joe Leigh Simpson, Zi-Jiang Chen*. Association of 8q22.3 locus in Chinese Han with idiopathic premature ovarian failure (POF).
Hum Mol Genet. 2012; 21(2): 430-6. （IF:7.692）
17.Yingying Qin,* Ting Guo, Guangyu Li, Tie-Shan Tang, Shidou Zhao, Xue Jiao, Juanjuan Gong, Fei
Gao, Caixia Guo, Joe Leigh Simpson, and Zi-Jiang Chen*. CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS Genet. 2015; 11(7):e1005419. （IF:7.528）
18.Hong Lv, Jing Tong, Jieqiong Yang, Shijian Lv, Wei-Ping Li*, Cong Zhang*, Zi-Jiang Chen*.
Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a Competing Endogenous RNA for Hexokinase 2 by Impairing Decidualization. Hypertension. 2018; 71(4):648-658. (IF:6.857)
19.Xue Jiao, Huihui Zhang, Hanni Ke, Jiangtao Zhang, Lei Cheng, Yixun Liu, Yingying Qin*, Zi-Jiang
Chen*. Premature Ovarian Insufficiency: Phenotypic Characterization within Different Etiologies. J Clin Endocrinol Metab. 2017 Jul 1; 102(7):2281-2290. (IF:5.455）
20.Daimin Wei, Bo Zhang, Yuhua Shi, …, Richard S Legro, Heping Zhang, Zi-Jiang Chen*. Effect of
Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2017;102(10):3822-3829. (IF:5.455）。