基于PEG的纳米胶束

PEG-PCL2 miktoarm star copolymers
Any number of various types of polymer arms emanate from a core.
Polym Chem, 2015, 6(4): 531-542.
The observed morphologies of amphiphilic self- assemblies depend on a variety of physicochemical factors, such as temperature, polymer–solvent interactions, and the presence of additives, as well as the preparation methods or micelle forming processes.
International Journal of Polymeric Materials, 2012, 61(5): 384-394.
star copolymer
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2010, 358(1-3): 128-134.
Generation 2 PAMAM dendrimer
dendrimer-star copolymer
Bioconjugate Chem, 2005, 16(2): 397-405.
Advanced Drug Delivery Reviews ,2001,47(1):113–131
amphiphilic diblock copolymer
Molecules with f >50% can be expected to form micelles, whereas molecules with f<25% can be expected to form inverted microstructures.
Annual Review of Biomedical EngineeΒιβλιοθήκη Baiduing,2006,8(1):323-341
Conventional micelles composed of amphiphilic linear copolymers have suffered from low drug-loading efficacies, insufficient stabilities and rapid initial release rates.
• various amphiphilic copolymer can be obtained based on PEG,
which further self-assemble into micelles in aqueous media.
diblock copolymer
Journal of Controlled Release , 2001, 70(1-2):63–70
Multi-responsive core-crosslinked micelles
Polymer, 2017, 110: 235-241.
The crosslinking structure can improve the drug loading capacity due to the compact and stable structure in aqueous media.
hyperbranched copolymer
Biomacromolecules, 2008, 9(10): 2578–2585
Boltorn 型 HBPester
H40理想结构
Macromolecules, 1995, 28(5): 1698-1703.
hyperbranched-linear-hyperbranched copolymer
PEG-based amphiphilic copolymer and its drug delivery applications
PEG:
• high water solubility ; • significant chain mobility;
• low toxicity;
• widely applied in biomedical field.