基于PEG的纳米胶束
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PEG-based amphiphilic copolymer and its drug delivery applications
PEG:
• high water solubility ; • significant chain mobility;
• low toxicity;
• widely applied in biomedical field.
Generation 2 PAMAM dendrimer
dendrimer-star copolymer
Bioconjugate Chem, 2005, 16(2): 397-405.
Advanced Drug Delivery Reviews ,2001,47(1):113–131
amphiphilic diblock copolymer
• various amphiphilic copolymer can be obtained based on PEG,
which further self-assemble into micelles in aqueous media.
diblock copolymer
Journal of Controlled Release , 2001, 70(1-2):63–70
hyperbranched copolymer
Biomacromolecules, 2008, 9(10): 2578–2585
Boltorn 型 HBPester
H40理想结构
Macromolecules, 1995, 28(5): 1698-1703.
hyperbranched-linear-hyperbranched copolymer
International Journal of Polymeric Materials, 2012, 61(5): 384-394.
star copolymer
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2010, 358(1-3): 128-134.
Conventional micelles composed of amphiphilic linear copolymers have suffered from low drug-loading efficacies, insufficient stabilities and rapid initial release rates.
PEG-PCL2 miktoarm star copolymers
Any number of various types of polymer arms emanate from a core.
Polym Chem, 2015, 6(4): 531-542.
The observed morphologies of amphiphilic self- assemblies depend on a variety of physicochemical factors, such as temperature, polymer–solvent interactions, and the presence of additives, as well as the preparation methods or micelle forming processes.
Multi-responsive core-crosslinked micelles
Polymer, 2017, 110: 235-241.
The crosslinking structure can improve the drug loading capacity due to the compact and stable structure in aqueous media.
Molecules with f >50% can be expected to form micelles, whereas molecules with f<25% can be expected to form inverted microstructures.
Annual Review of Biomed3-341
PEG:
• high water solubility ; • significant chain mobility;
• low toxicity;
• widely applied in biomedical field.
Generation 2 PAMAM dendrimer
dendrimer-star copolymer
Bioconjugate Chem, 2005, 16(2): 397-405.
Advanced Drug Delivery Reviews ,2001,47(1):113–131
amphiphilic diblock copolymer
• various amphiphilic copolymer can be obtained based on PEG,
which further self-assemble into micelles in aqueous media.
diblock copolymer
Journal of Controlled Release , 2001, 70(1-2):63–70
hyperbranched copolymer
Biomacromolecules, 2008, 9(10): 2578–2585
Boltorn 型 HBPester
H40理想结构
Macromolecules, 1995, 28(5): 1698-1703.
hyperbranched-linear-hyperbranched copolymer
International Journal of Polymeric Materials, 2012, 61(5): 384-394.
star copolymer
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2010, 358(1-3): 128-134.
Conventional micelles composed of amphiphilic linear copolymers have suffered from low drug-loading efficacies, insufficient stabilities and rapid initial release rates.
PEG-PCL2 miktoarm star copolymers
Any number of various types of polymer arms emanate from a core.
Polym Chem, 2015, 6(4): 531-542.
The observed morphologies of amphiphilic self- assemblies depend on a variety of physicochemical factors, such as temperature, polymer–solvent interactions, and the presence of additives, as well as the preparation methods or micelle forming processes.
Multi-responsive core-crosslinked micelles
Polymer, 2017, 110: 235-241.
The crosslinking structure can improve the drug loading capacity due to the compact and stable structure in aqueous media.
Molecules with f >50% can be expected to form micelles, whereas molecules with f<25% can be expected to form inverted microstructures.
Annual Review of Biomed3-341