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低分子肝素药理学和临床应用研究进展

王福清1,张春颖2

(1.中国商业联合会科技质量部,北京　100801;2.中国中医研究院中药研究所,北京　100700)

摘　要:综述了近年来国内外低分子肝素在药效学、药动学及临床应用等方面的研究进展。

关键词:低分子肝素;药理;临床应用

中图分类号:R969,R972 文献标识码:A 文章编号:100521678(2001)0520262204

Progress of low molecular w eight heparins in the pharmacology and clinic

W ANG Fu2qing1,ZH ANG Chun2ying2

(1.Dept.o f Sci2Tech&Quality Management,Commercial Association,Beijing100801,China;

2.Institute o f Chinese Materia Medica,China Academy o f T raditional Chinese Medicine,Beijing100700,China)

低分子肝素(low m olecular weight heparin,LMWH)是由肝素经降解得到的低分子量的片段或经分级法得到的4000～6500D低分子量组分。其抗血栓作用优于肝素,而抗凝血

收稿日期:2001207210

作者简介:王福清(1963年出生),男,生化药物学硕士,多年从事生化药物学研究和我国生化制药行业管理工作作用却低于肝素,具有生物利用度高,体内半衰期长,出血倾向小,口服易吸收等特点。由于其有效性和安全性均优于普通肝素,目前已成为肝素类药物研究的热点。本文就LMWH 在药理学和临床应用等方面的研究进展作一综述。

1　LMWH的药理学

目前国内外在临床上应用的LMWH类药物有吉派啉、达肝素钠(法安明)、Raxiparine、Nadroparin、Dalteparin、Enoxaparin、

262中国生化药物杂志Chinese Journal of Biochemical Pharmaceutics2001年第22卷第5期