优秀学术报告示例Ari Koskinen ppt课件
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Ari Koskinen Laboratory of Organic Chemistry
$ 1.7 bn (2003) per product is spent on
R&D Stage
% of spendinga
Synthesis/extraction
11.0
Biological screening/
C&EN January 17, 2000, Food & Drug Administration, Pharmaceutical Research & Manufacturers of America: PhRMA Annual Survey 2000.
Ari Koskinen Laboratory of Organic Chemistry
Mergers
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Off Patent
December 6, 2004 Volume 82, Number 49
pp. 18-29
New Drug Development
Ari Koskinen Laboratory of Organic Chemistry
R&D By Geographic Area; 2001
Africa Americas Europe Asia-Pacific Australia Middle East Others
3.8
Other
9.4
a Company financed R&D in US based on 1995 figures totalling $ 11.8 bn b US scientific and professional personnel totaling 34, 784 employees Source: Pharmaceutical Research & Manufacturers of America, Industry Pro
16.0
pharmacological testing
Toxicology/safety
6.0
Dosage formulation
9.6
Clinical evaluation
34.5
Process development for
9.6
manufacturing/ quality
control
Regulatory
R&D Spending $ billions
New molecular entities approved by FDA Ratio: $ / No.
Note: Ethical pharmaceuticals only. Expenditures worldwide by U.S.-owned research-based pharmaceutical companies
Ari Koskinen Laboratory of Organic Chemistry
Patents expiring
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Promising New Drugs
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Diversity of Drug Structures
Chemistry in Biomedicine and Drug Discovery
Professor Ari Koskinen Helsinki University of Technology
11.03.2005
Ari Koskinen Laboratory of Organic Chemistry
4,8 5,5 6,6 7,2 8,4 9,8 11,5 12,7 13,5 15,2 16,6 18,7 21,0 24,0
$ billions
60 0,70
50
பைடு நூலகம்
0,60
40
0,50
FDA30 Numbe2r0approvedby
10
0,40 $/No.
0,30
0,20
0,10
0
0,00
86 87 88 89 90 91 92 93 94 95 96 97 98 99
Ari Koskinen Laboratory of Organic Chemistry
Development pipeline
Ari Koskinen Laboratory of Organic Chemistry
Top 10 Therapies
December 6, 2004 Volume 82, Number 49
精品资料
• 你怎么称呼老师？
• 如果老师最后没有总结一节课的重点的难点，你是 否会认为老师的教学方法需要改进？
• 你所经历的课堂，是讲座式还是讨论式？ • 教师的教鞭
• “不怕太阳晒，也不怕那风雨狂，只怕先生骂我笨， 没有学问无颜见爹娘 ……”
• “太阳当空照，花儿对我笑，小鸟说早早早……”
New Chemical Entities vs. R&D Expedinture
2003 data: C&EN 2003, 81 (50), 8.
% of employeesb
12.9 18.3
7.8 11.6 24.3 10.3
4.8 10.0
Ari Koskinen Laboratory of Organic Chemistry
Market Exclusivity Times Decrease
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Top 10 Products
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
$ 1.7 bn (2003) per product is spent on
R&D Stage
% of spendinga
Synthesis/extraction
11.0
Biological screening/
C&EN January 17, 2000, Food & Drug Administration, Pharmaceutical Research & Manufacturers of America: PhRMA Annual Survey 2000.
Ari Koskinen Laboratory of Organic Chemistry
Mergers
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Off Patent
December 6, 2004 Volume 82, Number 49
pp. 18-29
New Drug Development
Ari Koskinen Laboratory of Organic Chemistry
R&D By Geographic Area; 2001
Africa Americas Europe Asia-Pacific Australia Middle East Others
3.8
Other
9.4
a Company financed R&D in US based on 1995 figures totalling $ 11.8 bn b US scientific and professional personnel totaling 34, 784 employees Source: Pharmaceutical Research & Manufacturers of America, Industry Pro
16.0
pharmacological testing
Toxicology/safety
6.0
Dosage formulation
9.6
Clinical evaluation
34.5
Process development for
9.6
manufacturing/ quality
control
Regulatory
R&D Spending $ billions
New molecular entities approved by FDA Ratio: $ / No.
Note: Ethical pharmaceuticals only. Expenditures worldwide by U.S.-owned research-based pharmaceutical companies
Ari Koskinen Laboratory of Organic Chemistry
Patents expiring
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Promising New Drugs
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Diversity of Drug Structures
Chemistry in Biomedicine and Drug Discovery
Professor Ari Koskinen Helsinki University of Technology
11.03.2005
Ari Koskinen Laboratory of Organic Chemistry
4,8 5,5 6,6 7,2 8,4 9,8 11,5 12,7 13,5 15,2 16,6 18,7 21,0 24,0
$ billions
60 0,70
50
பைடு நூலகம்
0,60
40
0,50
FDA30 Numbe2r0approvedby
10
0,40 $/No.
0,30
0,20
0,10
0
0,00
86 87 88 89 90 91 92 93 94 95 96 97 98 99
Ari Koskinen Laboratory of Organic Chemistry
Development pipeline
Ari Koskinen Laboratory of Organic Chemistry
Top 10 Therapies
December 6, 2004 Volume 82, Number 49
精品资料
• 你怎么称呼老师？
• 如果老师最后没有总结一节课的重点的难点，你是 否会认为老师的教学方法需要改进？
• 你所经历的课堂，是讲座式还是讨论式？ • 教师的教鞭
• “不怕太阳晒，也不怕那风雨狂，只怕先生骂我笨， 没有学问无颜见爹娘 ……”
• “太阳当空照，花儿对我笑，小鸟说早早早……”
New Chemical Entities vs. R&D Expedinture
2003 data: C&EN 2003, 81 (50), 8.
% of employeesb
12.9 18.3
7.8 11.6 24.3 10.3
4.8 10.0
Ari Koskinen Laboratory of Organic Chemistry
Market Exclusivity Times Decrease
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry
Top 10 Products
December 6, 2004 Volume 82, Number 49
pp. 18-29
Ari Koskinen Laboratory of Organic Chemistry