充液胶囊的研究进展

dati on of a diss oluti on test f or a once 2a 2day combinati on tablet of i m mediate 2release cetirizine dihydr ochl oride and extended 2release p seudoephedrine hydr ochl oride [J ].Phar ma B i omed Anal,

2005,39(324):543.

[24]　隋　红,李三鸣,施　路,等.盐酸万乃洛韦微孔渗透泵控释

片的制备及释药机理的研究[J ].中国药剂学杂志,2003,1

(3):81.

[25]　Ozyazici M,Gokce E H,Ertan G .Release and diffusi onal mod 2

eling of metr onidaz ole li p id matrices[J ].Eur J Phar m B i ophar m,2006,63(3):331.

[26]　Gothoskar A V.Study of effect of viscosity &poly mer:exci p ient

on drug 2release patterns fr om s wellable matrices[J ].D rug Deliv Tech,2005,5(5):46.

[27]　叶琳琳,胡宇华,陈　军,等.盐酸维拉帕米口服渗透泵制剂

释药特性的研究[J ].中国药学杂志,2002,33(12):590.

[28]　Kaushal A M ,Garg S .An update on os motic drug delivery pa 2

tents[J ].Phar ma Tech,2003,27:88,38.

[29]　候惠民,朱金屏.消炎痛“渗透泵”片的制备与体外释药试验

[J ].中国医院药学杂志,1982,2(5):1.

[30]　赵炎生,王长芳,夏　毅,等.控释片剂激光打孔机的研制

[J ].东南大学学报,1998,28(6):501.

[31]　Yang X G,Peng B,Zhang G H,et al .Studies of the phar maco 2

kinetics of paeonifl orin in t w o J ing 2Zhi 2Guan 2Xin f or mulati ons af 2ter oral adm inistrati on t o beagle dogs[J ].J Phar m B i omed Anal,2006,41(1):320.

[32]　安徽省现代中药研究中心1六味地黄或其加减方提取物的

渗透泵型控释制剂及其制备方法[P ]1中国:1891275A 120072

01210.

O s m oti ca lly con trolled ora l drug deli very syste m s:an upda te rev i ew

WANG W en 2p ing 1,2

,X I E Xiu 2qi ong 1

,Y ANG Da 2jian 2

,CHE N Shi 2lin

2,3

(1.College of Phar m aceutics,Chengdu U niversity of Traditional Chinese M edicine,Chengdu 610075,China;

2.M anicipal Key L aboratory of Chinese M edicine and M olecular Phar m acology of Shenzhen &Hong Kong Polytechnic

U niversity Institute of M odern Chinese M edicine,Shenzhen 518057,China;

3.Institute of M edicinal Plants,CAM S &PUM C,B eijing 100094,China )

[Abstract]　O s motically contr olled oral drug delivery syste ms (OC ODDSs )utilize os motic pressure f or contr olled delivery of active a 2gents .The release of drugs fr o m os motic syste ms is g overned by vari ous f or mulati ons and pr ocessing fact ors such as s olubility and p ressure of the core co mponents,pr operties of the se mi 2per meable me mbrane .I n the present revie w,the references on OC ODDSs have syste matically been su mmarized in the f oll o wing as pects :p rescri pti on design,industrial pr ocessing and equi pments,methods f or quality evaluati on,and gen 2eral situati on of applicati on .Pr os pect of applying the os motic 2pu mp technol ogy int o Chinese patent drugs is als o discussed .

[Key words]　os motic 2pu mp technol ogy;contr olled 2release drug delivery;zer o 2order release pattern

[责任编辑　鲍　雷]

[收稿日期]　2007206205

[通讯作者]　3杨明,Tel:(028)61800456,E 2mail:jiahua ma@1631com

充液胶囊的研究进展

马家骅,杨　明3

,曾　敏,陈雪梅,兰　洁

(成都中医药大学温江校区药学院,四川成都611130)

[摘要]　近年来新剂型不断涌现,充液胶囊就是其中之一,其采用明胶或羟丙基甲基纤维素(HP MC )外壳,以

全新概念的固体剂型液体释放而备受关注。作者主要介绍了充液胶囊的应用、制备、质量评价及其前景展望,重点介绍了充液胶囊的应用与制备,指出充液胶囊适于各种液体或半固体状天然植物提取物,并可达到不同的释药目的。其制备可采用液体灌装硬胶囊技术,影响因素主要有灌装材料的性质和设备情况。制剂常通过囊壳的水分、