分子药理学ppt课件
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This molecular structure is called a
receptor.
Receptor + Drug ? Complex ? ? ?
Responses 6
DRUG RECEPTORS AND BIOLOGICAL RESPONSES
Receptor: molecular substances or macromolecules in tissues that combine chemically with the drug.
近代药理学的进展，主要表现在受体理论、离子通道、信息传 递、细胞因子等分子水平上的研究突破。分子药理学是指其学 科层次、水平上的科学性和先进性达到“分子水平 ”，且又属 于“药理学”范畴，分子生物学等相关学科的基础知识贯穿其 中。
4
药物的作用机制
Receptors Drug/receptors and biological
喻凯
11．神经药理的分子药理学基础 12．学习、记忆药理及老年痴呆的药物干预 13．细胞凋亡机理及抗癌药物研究进展 14．氧自由基与抗氧化剂及一氧化氮 考核方式： 上课情况15%， 学期论文25%，考试60%
黄新河
3
日期 9/11
9/18 9/25
10/9
10/16 10/23
5
Receptor
A fundamental concept of pharmacology: to initiate an effect in a cell, most drugs combine with some molecular structure on the surface of or within the cell.
7
Agonist vs Antagonist
Chemicals that interact with a receptor to initiate a cellular reaction are termed agonists.
Antagonist interacts with the receptor and prevents the interaction of agonist with its receptor.
binding proteins. G proteins have the capacity to bind guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP).
Receptor activation, Gቤተ መጻሕፍቲ ባይዱprotein, adenylyl cyclase, ATP-cAMP, kinases activation, protein phosphorylation.
Ach receptor → Na influx → action potential → increased free Ca → contraction
Specific receptive substances serve as triggers of cellular reactions.
分子药理学
1
教学大纲
中文名称 分子药理学 英文名称 Molecular Pharmacology
课内总学时：32 教学方式：讲授 撰写人：晏为力 考核方式：考试+论文报告 开课学期： Ⅰ 学分数: 2 内容偏重：理论
教学要求及目的
１．使学生了解分子药理学的基础知识和各系统分子药理学的进展，为从事药学基础 研究工作和新药开发奠定理论基础。
8
SECOND-MESSENGER SYSTEMS
Many receptors are capable of initiating a chain of events involving second messengers.
G proteins, short for guanine nucleotide–
2
课程内容
内容 1．绪论: 分子药理学研究内容, 药物作用的机制 晏为力 2．受体药理及信号传导 3．细胞内第二信使蛋白激酶及有关药物进展 4．炎症介质与抗炎药物
授课人
5．抗糖尿病药物 6．缺血再灌注性损伤的分子机制
谭睿
7．抗体及生物技术药物分子药理学基础 8．离子通道和抗心律失常药理 9．高血压药的分子药理学 10．细胞色素p450及调控
10/30 11/6 11/13 11/20
11/27 12/4
12/11 12/18
分子药理学（Molecular Pharmacology)
分子药理学属于一门新兴学科，其与传统药理学的最大区别就 在于，它是从分子水平和基因表达的角度去阐释药物作用及其 机制。
The use of techniques of molecular biology to enhance the understanding of the mechanism of action of existing drugs, and with the help of molecular graphics to predict the structure of novel drugs, especially compounds that might bind to proteins of known structure.
• Which G protein couples with the receptor
responses Second-messenger systems The chemistry of drug-receptor
binding Dynamics of drug-receptor binding Dose response relationship Potency and intrinsic activity Drug antagonism
receptor.
Receptor + Drug ? Complex ? ? ?
Responses 6
DRUG RECEPTORS AND BIOLOGICAL RESPONSES
Receptor: molecular substances or macromolecules in tissues that combine chemically with the drug.
近代药理学的进展，主要表现在受体理论、离子通道、信息传 递、细胞因子等分子水平上的研究突破。分子药理学是指其学 科层次、水平上的科学性和先进性达到“分子水平 ”，且又属 于“药理学”范畴，分子生物学等相关学科的基础知识贯穿其 中。
4
药物的作用机制
Receptors Drug/receptors and biological
喻凯
11．神经药理的分子药理学基础 12．学习、记忆药理及老年痴呆的药物干预 13．细胞凋亡机理及抗癌药物研究进展 14．氧自由基与抗氧化剂及一氧化氮 考核方式： 上课情况15%， 学期论文25%，考试60%
黄新河
3
日期 9/11
9/18 9/25
10/9
10/16 10/23
5
Receptor
A fundamental concept of pharmacology: to initiate an effect in a cell, most drugs combine with some molecular structure on the surface of or within the cell.
7
Agonist vs Antagonist
Chemicals that interact with a receptor to initiate a cellular reaction are termed agonists.
Antagonist interacts with the receptor and prevents the interaction of agonist with its receptor.
binding proteins. G proteins have the capacity to bind guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP).
Receptor activation, Gቤተ መጻሕፍቲ ባይዱprotein, adenylyl cyclase, ATP-cAMP, kinases activation, protein phosphorylation.
Ach receptor → Na influx → action potential → increased free Ca → contraction
Specific receptive substances serve as triggers of cellular reactions.
分子药理学
1
教学大纲
中文名称 分子药理学 英文名称 Molecular Pharmacology
课内总学时：32 教学方式：讲授 撰写人：晏为力 考核方式：考试+论文报告 开课学期： Ⅰ 学分数: 2 内容偏重：理论
教学要求及目的
１．使学生了解分子药理学的基础知识和各系统分子药理学的进展，为从事药学基础 研究工作和新药开发奠定理论基础。
8
SECOND-MESSENGER SYSTEMS
Many receptors are capable of initiating a chain of events involving second messengers.
G proteins, short for guanine nucleotide–
2
课程内容
内容 1．绪论: 分子药理学研究内容, 药物作用的机制 晏为力 2．受体药理及信号传导 3．细胞内第二信使蛋白激酶及有关药物进展 4．炎症介质与抗炎药物
授课人
5．抗糖尿病药物 6．缺血再灌注性损伤的分子机制
谭睿
7．抗体及生物技术药物分子药理学基础 8．离子通道和抗心律失常药理 9．高血压药的分子药理学 10．细胞色素p450及调控
10/30 11/6 11/13 11/20
11/27 12/4
12/11 12/18
分子药理学（Molecular Pharmacology)
分子药理学属于一门新兴学科，其与传统药理学的最大区别就 在于，它是从分子水平和基因表达的角度去阐释药物作用及其 机制。
The use of techniques of molecular biology to enhance the understanding of the mechanism of action of existing drugs, and with the help of molecular graphics to predict the structure of novel drugs, especially compounds that might bind to proteins of known structure.
• Which G protein couples with the receptor
responses Second-messenger systems The chemistry of drug-receptor
binding Dynamics of drug-receptor binding Dose response relationship Potency and intrinsic activity Drug antagonism