经鼻高流量鼻导管湿化氧疗治疗中老年重症难治性肺炎合并呼吸衰竭的临床观察

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㊀㊀ʌ摘㊀要ɔ㊀目的㊀观察经鼻高流量鼻导管湿化氧疗治疗中老年重症难治性肺炎合并呼吸衰竭患者疗效及其对氧饱和度及预后的影响ꎮ方法㊀2016年4月 2018年4月河北省衡水市第二人民医院呼吸消化科诊疗重症难治性肺炎合并呼吸衰竭患者240例ꎬ随机数字表法分成2组ꎬ每组120例ꎮ对照组给予抗炎㊁平喘以及化痰等常规治疗联合经鼻正压通气吸氧治疗ꎬ观察组在常规治疗基础上给予经鼻高流量鼻导管湿化氧疗治疗ꎮ观察比较2组患者紫绀㊁气短以及肺部啰音等症状消失时间㊁生活质量及呼吸困难情况ꎬ以及动脉血气分析㊁氧饱和度改善及炎性因子变化ꎮ结果㊀治疗后ꎬ观察组肺部啰音消失时间㊁气短消失时间㊁紫绀消失时间㊁SGRQ评分㊁Borg评分㊁IL ̄1㊁TNF ̄α㊁CRP水平㊁PaO2㊁SaO2㊁PaCO2均优于对照组ꎬ差异均有统计学意义(t/P=10.077/0.000㊁12.532/0.000㊁17.553/0.000㊁14.483/0.000㊁15.458/0.000㊁21.289/0.000㊁19.999/0.000㊁24.498/0.000㊁16.872/0.000㊁8.401/0.000㊁7.264/0.000)ꎮ结论㊀采用经鼻高流量鼻导管湿化氧疗ꎬ能够改善重症难治性肺炎合并呼吸衰竭患者呼吸困难ꎬ促进疾病相关临床症状恢复ꎬ可以有效控制病情发展ꎬ改善患者预后ꎮ

ʌ关键词ɔ㊀鼻导管ꎻ氧疗ꎻ重症难治性肺炎ꎻ呼吸衰竭

ʌDOIɔ㊀10.3969/j.issn.1671 ̄6450.2019.02.007

Clinicalobservationofnasalhigh ̄flownasalcanalhumidificationoxygentherapyformiddle ̄agedandelderlypatientswithsevererefractorypneumoniacomplicatedwithrespiratoryfailure㊀FUHuiwenꎬZHAOZhidongꎬGUOAnꎬLINHuaiyinꎬSUNTao.DepartmentofRespiratoryandGastroenterologyꎬHengshuiSecondPeople'sHospitalꎬHebeiProvinceꎬHeng ̄shui053000ꎬChina

Correspondingauthor:ZHAOZhidongꎬE ̄mail:zhaozhidongdejia@163.com

㊀㊀ʌAbstractɔ㊀Objective㊀Toobservetheeffectofnasalhigh ̄flownasalcatheterhumidificationoxygentherapyonthetreat ̄mentofelderlypatientswithsevererefractorypneumoniacomplicatedwithrespiratoryfailureanditseffectonoxygensaturationandprognosis.Methods㊀FromApril2016toApril2018ꎬ240patientswithsevererefractorypneumoniacomplicatedwithre ̄spiratoryfailureweretreatedbytheDepartmentofRespiratoryandGastroenterologyꎬSecondPeople'sHospitalofHengshuiCityꎬHebeiProvince.Therandomnumbertablemethodwasdividedintotwogroupsꎬ120casesineachgroup.Thecontrolgroupwasgivenconventionaltreatmentssuchasanti ̄inflammatoryꎬantiasthmaticandphlegmcombinedwithnasalpositivepressureventila ̄tion.Theobservationgroupwasgivenahigh ̄flownasalcatheterhumidificationoxygentherapyonthebasisofconventionaltreat ̄ment.Thedisappearancetimeꎬqualityoflifeanddyspneaofsymptomssuchaspurpuraꎬshortnessofbreathandlungvocaliza ̄tionwereobservedinthetwogroups.Arterialbloodgasanalysisꎬoxygensaturationimprovementandinflammatoryfactorswereobserved.Results㊀AftertreatmentꎬthedisappearancetimeoflungvoiceꎬdisappearancetimeofairshortnessꎬdisappearancetimeofpurpuraꎬSGRQscoreꎬBorgscoreꎬIL ̄1ꎬTNF ̄αꎬCRPlevelꎬPaO2ꎬSaO2ꎬPaCO2werebetterthanthoseofthecontrolgroup.Significance(t/P=10.077/0.000ꎬt/P=12.532/0.000ꎬt/P=17.553/0.000ꎬt/P=14.483/0.000ꎬt/P=15.458/0.000ꎬt/P=21.289/0.000ꎬt/P=19.999/0.000ꎬt/P=24.498/0.000ꎬt/P=16.872/0.000ꎬt/P=8.401/0.000ꎬt/P=7.264/0.000).Conclusion㊀Theuseofnasalhigh ̄flownasalcatheterhumidificationoxygentherapycanimprovethedyspneaofpatientswithsevererefractorypneumoniacomplicatedwithrespiratoryfailureꎬpromotetherecoveryofdisease ̄relatedclinicalsymptomsꎬandeffectivelycontrolthedevelopmentofthediseaseandimprovetheprognosisofpatients.

㊀㊀ʌKeywordsɔ㊀NasalcatheterꎻOxygentherapyꎻSevererefractorypneumoniaꎻRespiratoryfailure

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