6-Aminonicotinamide_6-磷酸葡萄糖酸脱氢酶抑制剂_329-89-5_Apexbio

Ki: 0.46 μM 6-Aminonicotinamide is a 6-phosphogluconate dehydrogenase inhibitor. 6-Phosphogluconate dehydrogenase, an enzyme in the pentose phosphate pathway, can produce ribulose 5-phosphate from 6-phosphogluconate. 6-Phosphogluconate dehydrogenase is also an oxidative carboxylase catalyzing the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP.
产品说明书
化学性质
产品名: 6-Aminonicotinamide 修订日期: 6/30/2016
Biblioteka Baidu
产品名: Cas No.: 分子量: 分子式: 别名: 化学名: SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
6-Aminonicotinamide
329-89-5
137.1
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参考文献:
特别声明
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C6H7N3O
6-AN,NSC 21206,SR 4388
6-amino-3-pyridinecarboxamide
Nc1ccc(cn1)C(=O)N
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Metabolism
信号通路:
Dehydrogenase
产品描述:
ApexBio Technology
In vitro: 6-Aminonicotinamide could be metabolized to 6-amino-NAD(P+), a competitive inhibitor of NAD(P+)-requiring processes, especially the pentose phosphate pathway enzyme, 6-phosphogluconate dehydrogenase. Moreove, 6-aminonicotinamide as a single agent could cause a significant inhibition of glycolytic flux but had no effect on the pentose phosphate pathway. 31P-NMR studies of perifused RIF-1 cells indicated that 4 h of exposure to 6-aminonicotinamide was enough to cause significant accumulation of 6-phosphogluconate, the substrate for this enzyme [1]. In vivo: The influence of 6-aminonicotinamide on the G-6-P-DH- and 6-PG-DH-levels of the pentose phosphate pathway in the kidney was investigated. Following i.p. administration of 6-aminonicotinamide at 6 mg/kg, the 6-PG-level rose from a value less than 10 nmoles/g to 1000 nmoles/g fresh weight within 24 h. In addition, at the end of the assay, after 7 days, a 6-PG-concentration of about 150 nmoles/g fresh weight was still seen. Moreove, the G-6-P level simultaneously rose with the 6-PG-level to about 150% of the control level and returned to normal on the 5th day [2]. Clinical trial: So far, no clinical study has been conducted.