SII、MLR与慢性淋巴细胞性甲状腺炎的相关性研究

Advances in Clinical Medicine 临床医学进展, 2020, 10(3), 430-435

Published Online March 2020 in Hans. /journal/acm

https:///10.12677/acm.2020.103068

The Relationship between SII, MLR

and Chronic Lymphocytic Thyroiditis

Min Liu*#, Ang Xing, Song Hu, Yongjun Mao, Xiujuan Jia

Qingdao University, Qingdao Shandong

Received: Mar. 5th, 2020; accepted: Mar. 20th, 2020; published: Mar. 27th, 2020

Abstract

Objective: Exploring the correlation between Systematic Immune-inflammatory Index (SII), Mono-cyte-to-Lymphocyte Ratio (MLR) and CLT in women with normal thyroid function. Methods: 70 CLT women with normal thyroid function and 70 healthy controls of similar age are enrolled in the study.

We compare SII, MLR, Platelet count, Neutrophil count, Lymphocyte count, Thyroid Stimulating Hor-mone (TSH), Thyroid Peroxidase Antibodies (TPO-Ab) and Thyroglobulin Antibodies (TG-Ab) between the two groups to indicate whether there is a difference. We make logistic analysis to make sure the danger factors of CLT. And we also analyze the correlation between SII, MLR and TSH, Anti-TPO and Anti-Tg within CLT group. Results: Age, BMI, platelet count, monocyte count, neutrophil count, lym-phocyte count, FT4, and FT3 of patients in the CLT group are not significantly different compared with the control group (p > 0.05). The SII, MLR, TSH, Anti-Tg and Anti-TPO of the CLT group are higher than the control group, and the difference is statistically significant (p < 0.05). Logistic analysis exposed that SII and MLR are the risk factors of CLT. Pearson correlation analysis indicated that SII, MLR are corre-lated with serum TSH, Anti-Tg and Anti-TPO respectively, and the difference was statistically signifi-cant (p < 0.05). Conclusion: In this study, SII, MLR of CLT patients with normal thyroid function are higher than that of healthy controls. SII, MLR may be nonspecific indicators of immune dysfunction and may be predictors of CLT. The effect of SII and MLR on CLT needs further studys.

Keywords

Chronic Lymphocytic Thyroiditis, Systematic Immune-Inflammatory Index,

Monocyte-To-Lymphocyte Ratio

SII、MLR与慢性淋巴细胞性甲状腺炎的相关性研究

刘敏*#，邢昂，胡松，毛拥军，贾秀娟

*第一作者。

#通讯作者。

刘敏 等

青岛大学，山东 青岛

收稿日期：2020年3月5日；录用日期：2020年3月20日；发布日期：2020年3月27日

摘 要

目的：探究SII 、MLR 与女性慢性淋巴细胞性甲状腺炎(Chronic lymphocytic thyroiditis, CLT)之间的关系。方法：本研究纳入70名甲状腺功能正常的女性CLT 患者和70名年龄相匹配的健康女性作为对照组，比较两组之间的系统免疫炎症指数(Systematicimmune-inflammatory index, SII)、单核细胞淋巴细胞比值(Monocyte-to-lymphocyte ratio)、血小板计数(Platelet count)、单核细胞计数(Monocyte count)、中性粒细胞计数(neutrophil count)、淋巴细胞计数(Lymphocyte count)、促甲状腺激素(Thyroidstimulating hormone, TSH)、抗甲状腺过氧化物酶抗体(Anti-TPO)、抗甲状腺球蛋白抗体(Anti-TG)有无差异，对组数据进行Logistic 回归分析CLT 的危险因素，pearson 分析CLT 组内的SII 、MLR 与TSH 、Anti-TPO 及Anti-Tg 之间的相关性。结果：CLT 组患者的年龄、BMI 、单核细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、游离甲状腺素(Free T 4, FT 4)、游离三碘甲状腺原氨酸(Free T 3, FT 3)与正常对照组相比无显著差异(p > 0.05)。CLT 组患者的SII 、MLR 、TSH 、Anti-Tg 、Anti-TPO 均高于正常对照组，且差异有统计学意义(p < 0.05)。Logistic 回归分析显示SII 、MLR 是CLT 的危险因素(p < 0.05)。Pearson 相关分析显示，SII 、MLR 分别与血清TSH 水平、Anti-Tg 及Anti-TPO 滴度相关，且差异有统计学意义(p < 0.05)。结论：本研究发现甲状腺功能正常的女性CLT 患者SII 、MLR 高于健康对照组。SII 、MLR 可能是免疫功能紊乱的非特异指标，可能对CLT 有预测作用。SII 、MLR 对CLT 的影响需要进一步研究。

关键词

慢性淋巴细胞性甲状腺炎，系统免疫炎症指数，单核细胞淋巴细胞比值

Copyright © 2020 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). /licenses/by/4.0/

1. 引言

慢性淋巴细胞性甲状腺炎(Chronic lymphocytic thyroiditis, CLT)，也称为桥本式甲状腺炎(hashimoto’s thyroiditis, HT)，是一种常见的器官特异性自身免疫性甲状腺疾病，其特征是抗甲状腺抗原的甲状腺自身抗体存在，如抗甲状腺球蛋白抗体(Anti-Tg)、抗甲状腺过氧化物酶抗体(Anti-TPO)等，其病理学表现为甲状腺实质组织被逐渐破坏、纤维替代、腺体弥漫性浸润、T 细胞增敏等[1]，是原发性甲状腺功能减退症最常见的原因[2]。研究表明，遗传、环境和自身免疫炎症因素共同作用导致CLT 的发病[3]，但其发病机制仍未完全阐明。

血常规的中性粒细胞、单核细胞、淋巴细胞和血小板是免疫系统的一部分，是评估炎症的重要指标。系统免疫炎症指数(Systematicimmune-inflammatory index, SII)是一种血常规相关的新型炎症指标，也被称为系统免疫炎症标记物，近年来越来越多地被用于预测急慢性炎症性疾病[4] [5]。单核细胞淋巴细胞比值(Monocyte-to-lymphocyte ratio, MLR)也是近3年被发现的新型血常规相关的炎症指标。在国外，SII 和MLR 多被用于某些癌症如肝癌、胃癌、乳腺癌、肺癌、睾丸癌、胶质瘤等的预后指标[6]-[11]。然而，目