发酵法生产透明质酸菌种的选育

北京化工大学学报

JOURNAL OF

BEIJING

UNIVERSITY

OF CHEMICAL

TECHNOLOGY

1999年第1期No.1

Vol.261999

发酵法生产透明质酸菌种的选育

张淑荣　许伟坚　张　鹏　孟庆云谭天伟

摘　要　用物理方法紫外线、γ射线及辅助磁场筛选、诱变兽疫链球菌，研究获得性状优良、产量相对稳定的透明质酸高产菌种，透明质酸产量可稳定在3～5 g/L。

关键词　筛选；诱变；兽疫链球菌

分类号　TQ929.2

Mutation and selection of high hyaluronic acid production strains

Zhang Shurong1) Xu Weijian1) Zhang Peng1) Meng Qingyun 2) Tan Tianwei1)

( 1) Department of Biochemical engineering, College of Chemical Engineering, Beijing University

of Chemical Technology;

2) Department of Applied Mathematics and Physics, Beijing University of Chemical Technology,

Beijing, 100029)

Abstract Different mutation methods such as UV, γ-rays and γ-ray combined with magnet ic treatment were studied in the mutation of streptoccus zooepidemicus to ge t high production of hyaluronic acid (HA). A high HA production strain was obtai ned by the γ-ray combined with magnetic treatment, in which 3～5 g/L HA prod uced could reach.

Key words screen; mutation; streptoccus zooepidemicus

引　言

透明质酸(Hyaluronic acid, HA)是一种大分子的粘多糖，它是一种由β-D-N -乙酰氨基葡萄糖和β-D-葡萄糖醛酸为结构单元，以β-1， 4-糖苷键连接而成的一种链状高分子粘多糖。

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