Lasofoxifene (tartrate)_第三代非甾体选择性雌激素受体调节剂(SERM)_190791-29-8_Apexbio

OC(C=C1)=CC2=C1[C@@H](C3=CC=C(OCCN4CCCC4)C=C3)[C@@H]( C5=CC=CC=C5)CC2.OC([C@@H](O)[C@H](O)C(O)=O)=O
Soluble in Байду номын сангаасMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
antagonists in others [1][2]. Lasofoxifene, also known as CP 336,156, is a third-generation, nonsteroidal selective estrogen receptor modulator. Lasofoxifene bound with high affinity to the human estrogen receptor-α with IC50 value of 1.5 nM [1]. Lasofoxifene is also a CB2 inverse agonist [4]. In aged female rats, Lasofoxifene decreased total serum cholesterol and fat body mass, and no uterine hypertrophy was observed. In 5-month-old ovariectomized (OVX) Sprague-Dawley female rats, Lasofoxifene completely prevented OVX-induced increases in body weight gain, total serum cholesterol, and serum osteocalcin. CP-336,156 completely prevented OVX-induced bone loss and inhibited the increased bone turnover associated with estrogen deficiency in lumbar vertebrae, proximal tibiae, and distal femora [1]. In postmenopausal women with osteoporosis, lasofoxifene reduced risks of nonvertebral and vertebral fractures, ER-positive breast cancer, coronary heart disease, and stroke but an increased risk of venous thromboembolic events [2][3]. 参考文献:
产品说明书
化学性质
产品名: Lasofoxifene (tartrate) 修订日期: 6/30/2016
产品名: Cas No.: 分子量: 分子式: 别名: 化学名:
SMILES:
溶解性: 储存条件: 一般建议:
运输条件:
Lasofoxifene (tartrate)
190791-29-8
563.6
特别声明
产品仅用于研究，
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ApexBio Technology
Estrogen/progestogen Receptor
产品描述:
Lasofoxifene (tartrate) is a third-generation, nonsteroidal selective estrogen receptor modulator (SERM). Estrogen receptors are activated by the hormone estrogen (17β-estradiol). SERMs are characterized by having estrogen agonist action in some tissues while acting as estrogen
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Endocrinology and Hormones
信号通路:
//struct//
C28H31NO2 • C4H6O6
CP 336,156
(5R,6S)-5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]p henyl]-2-naphthalenol, (2S,3S)-2,3-dihydroxybutanedioate