Domperidone_DataSheet_MedChemExpress
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Inhibitors, Agonists, Screening Libraries
Data Sheet
BIOLOGICAL ACTIVITY:
Domperidone is a dopamine blocker and an antidopaminergic reagent.
Target: Dopamine Receptor
Domperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side–effects from domperidone may be influenced by patient–related factors including polymorphisms in genes encoding
drug–metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist,which has been used as antiemetic agent in human beings. The percentage recovery of domperidone from wastewater was 95.0%.Celiprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater [2]. Domperidone, a dopamine antagonist that does not easily cross the blood–brain barrier, is considered the gold standard for treating gastrointestinal symptoms in patients with Parkinson's disease (PD) because the risk of developing extrapyramidal adverse effects is considered minimal [3].
References:
[1]. Parkman, H.P., et al., Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side–effects.Dig Dis Sci, 2011. 56(1): p. 115–24.
[2]. Ali, I., et al., Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta, 2006.68(3): p. 928–31.
[3]. Lertxundi, U., et al., Domperidone in Parkinson's disease: a perilous arrhythmogenic or the gold standard. Curr Drug Saf, 2013. 8(1): p. 63–8.
Product Name:
Domperidone Cat. No.:
HY-B0411CAS No.:
57808-66-9Molecular Formula:
C 22H 24ClN 5O 2Molecular Weight:
425.91Target:
Dopamine Receptor; Dopamine Receptor Pathway:
GPCR/G Protein; Neuronal Signaling Solubility:
10 mM in DMSO
Caution: Product has not been fully validated for medical applications. For research use only.
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