Clopidogrel-thiolactone-COA-17503-MedChemExpress
TALON Superflow Metal Affinity Resin说明书
Safety Data SheetRevision Date 2022-12-26Revision Number 91. IdentificationProduct identifier Product NameTALON Superflow Metal Affinity ResinOther means of identification Product Code635670 UN number or ID number UN3082SynonymsNo information availableRecommended use of the chemical and restrictions on use Identified uses No information available Restrictions on useNo information availableDetails of the supplier of the safety data sheetEmergency telephone number Emergency telephoneIn case of emergency, call PERS (Professional Emergency Resource Services) 1-800-633-8253 (US) or 801-629-0667 (international).2. Hazard(s) identificationProduct Classification Data Acute toxicity - Oral Category 2 CarcinogenicityCategory 1AHazards not otherwise classified (HNOC) Not applicable Label elements Supplier USA:Takara Bio USA, Inc. 2560 Orchard Parkway San Jose, CA 95131, USAPhone: 800.662.2566/888.251.6618 Web: DangerHazard statements Fatal if swallowed May cause cancerAppearance Pink slurry Physical state Paste / Gel Liquid Odor Alcohol Precautionary Statements - PreventionObtain special instructions before useDo not handle until all safety precautions have been read and understoodWear protective gloves/protective clothing/eye protection/face protectionWash face, hands and any exposed skin thoroughly after handlingDo not eat, drink or smoke when using this productPrecautionary Statements - ResponseIF exposed or concerned: Get medical advice/attentionSpecific treatment (see supplemental first aid instructions on this label)IF SWALLOWED: Immediately call a POISON CENTER or doctorRinse mouthPrecautionary Statements - StorageStore locked upPrecautionary Statements - DisposalDispose of contents/container to an approved waste disposal plantUnknown acute toxicity50.941 % of the mixture consists of ingredient(s) of unknown acute oral toxicityOther informationHarmful to aquatic life with long lasting effects. Harmful to aquatic life.3. Composition/information on ingredientsSubstanceNot applicable.MixtureChemical name CAS No Weight-% Trade secret Ethanol 64-17-5 10 - 20 *4. First-aid measuresDescription of first aid measuresGeneral advice Immediate medical attention is required. Show this safety data sheet to the doctor inattendance. IF exposed or concerned: Get medical advice/attention.Inhalation Remove to fresh air.Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids.Consult a physician.Skin contact Wash skin with soap and water.Ingestion Get immediate medical advice/attention. Do NOT induce vomiting. Clean mouth with waterand drink afterwards plenty of water. Never give anything by mouth to an unconsciousperson.Most important symptoms and effects, both acute and delayedSymptoms No information available.Indication of any immediate medical attention and special treatment neededNote to physicians Treat symptomatically.5. Fire-fighting measuresSuitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.Specific hazards arising from thechemicalNo information available.Explosion DataSensitivity to mechanical impact None.Sensitivity to static discharge None.Special protective equipment for fire-fighters Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear. Use personal protection equipment.6. Accidental release measuresPersonal precautions, protective equipment and emergency proceduresPersonal precautions Ensure adequate ventilation.Other information Refer to protective measures listed in Sections 7 and 8.Methods and material for containment and cleaning upMethods for containment Prevent further leakage or spillage if safe to do so.Methods for cleaning up Pick up and transfer to properly labeled containers.7. Handling and storagePrecautions for safe handlingAdvice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact withskin, eyes or clothing.Conditions for safe storage, including any incompatibilitiesStorage Conditions Store locked up. Keep containers tightly closed in a dry, cool and well-ventilated place.Keep out of the reach of children.8. Exposure controls/personal protectionControl parametersExposure LimitsChemical name ACGIH TLV OSHA PEL NIOSHEthanol 64-17-5 STEL: 1000 ppm TWA: 1000 ppmTWA: 1900 mg/m3(vacated) TWA: 1000 ppm(vacated) TWA: 1900 mg/m3IDLH: 3300 ppmTWA: 1000 ppmTWA: 1900 mg/m3Appropriate engineering controlsEngineering controls ShowersEyewash stationsVentilation systems.Individual protection measures, such as personal protective equipmentEye/face protection No special protective equipment required.Hand protection Wear suitable gloves.Skin and body protection Wear suitable protective clothing.Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits areexceeded or irritation is experienced, ventilation and evacuation may be required. General hygiene considerations Do not eat, drink or smoke when using this product. Wash hands before breaks andimmediately after handling the product.9. Physical and chemical propertiesInformation on basic physical and chemical propertiesPhysical state Paste / Gel LiquidAppearance Pink slurryColor No information availableOdor AlcoholOdor Threshold No information availableProperty Values Remarks • MethodpH No data available None knownMelting point / freezing point No data available None knownBoiling point/boiling range (°C) No data available None knownFlash point No data available Open cupEvaporation Rate No data available None knownFlammability (solid, gas) No data available None knownFlammability Limit in Air None knownUpper flammability limit: No data availableLower flammability limit: No data availableVapor pressure No data available None knownVapor density No data available None knownRelative density No data available None knownWater solubility No data available None knownSolubility in other solvents No data available None knownPartition coefficient No data available None knownAutoignition temperature 363 °C / 685.4 °F None knownDecomposition temperature None knownKinematic viscosity No data available None knownDynamic Viscosity No data available None knownOther informationExplosive properties No information availableOxidizing properties No information availableSoftening point No information availableMolecular weight No information availableVOC content No information availableLiquid Density No information availableBulk Density No information available10. Stability and reactivityReactivity No information available.Chemical stability Stable under normal conditions.Possibility of hazardous reactions None under normal processing.Conditions to Avoid None known based on information supplied.Incompatible materials None known based on information supplied.Hazardous decomposition products None known based on information supplied.11. Toxicological informationInformation on likely routes of exposureProduct InformationInhalation Specific test data for the substance or mixture is not available.Eye contact Specific test data for the substance or mixture is not available.Skin contact Specific test data for the substance or mixture is not available.Ingestion Specific test data for the substance or mixture is not available. Fatal if swallowed. (based oncomponents).Symptoms related to the physical, chemical and toxicological characteristicsSymptoms No information available.Acute toxicityNumerical measures of toxicityThe following values are calculated based on chapter 3.1 of the GHS documentATEmix (oral) 9.81 mg/kgATEmix (inhalation-dust/mist) 573.50 mg/lUnknown acute toxicity50.941 % of the mixture consists of ingredient(s) of unknown acute oral toxicityComponent InformationChemical name Oral LD50 Dermal LD50 Inhalation LC50 Ethanol = 7060 mg/kg ( Rat ) - = 116.9 mg/L ( Rat ) 4 h64-17-5 = 133.8 mg/L ( Rat ) 4 hDelayed and immediate effects as well as chronic effects from short and long-term exposureSkin corrosion/irritation No information available.Serious eye damage/eye irritation No information available.Respiratory or skin sensitization No information available.Germ cell mutagenicity No information available.Carcinogenicity Contains a known or suspected carcinogen. Classification based on data available foringredients. May cause cancer.The table below indicates whether each agency has listed any ingredient as a carcinogen.Chemical name ACGIH IARC NTP OSHA Ethanol64-17-5A3 Group 1 Known XLegendACGIH (American Conference of Governmental Industrial Hygienists)A3 - Animal CarcinogenIARC (International Agency for Research on Cancer)Group 1 - Carcinogenic to HumansNTP (National Toxicology Program)Known - Known CarcinogenOSHA (Occupational Safety and Health Administration of the US Department of Labor)X - PresentReproductive toxicity No information available.STOT - single exposure No information available.STOT - repeated exposure No information available.Target organ effects Liver, Respiratory system, Eyes, Skin, Central nervous system, Blood, Reproductivesystem.Aspiration hazard No information available.Other adverse effects No information available.Interactive effects No information available.12. Ecological informationEcotoxicity Harmful to aquatic life with long lasting effects.Chemical name Algae/aquatic plants Fish Toxicity tomicroorganismsCrustaceaEthanol 64-17-5 - LC50: 12.0 - 16.0mL/L(96h, Oncorhynchus- LC50: 9268 - 14221mg/L(48h, Daphnia magna)mykiss)LC50: >100mg/L (96h, Pimephales promelas) LC50: 13400 - 15100mg/L (96h, Pimephalespromelas) EC50: =2mg/L (48h, Daphnia magna)Persistence and degradability No information available.Bioaccumulation There is no data for this product.Component InformationChemical name Partition coefficientEthanol64-17-5-0.35Other adverse effects No information available.13. Disposal considerationsWaste treatment methodsWaste from residues/unused products Dispose of in accordance with local regulations. Dispose of waste in accordance with environmental legislation.Contaminated packaging Do not reuse empty containers.California Hazardous Waste Status This product contains one or more substances that are listed with the State of California asa hazardous waste.14. Transport informationDOTUN number or ID number UN3082Proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIISpecial Provisions 8, 146, 173, 335, 441, IB3, T4, TP1, TP29DOT Marine Pollutant NPDescription UN3082, Environmentally hazardous substance, liquid, n.o.s., 9, IIIEmergency Response GuideNumber171TDGUN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIISpecial Provisions 16, 99Description UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol), 9, IIIMEXUN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIITechnical Name EthanolDescription UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol), 9, IIISpecial Provisions 274, 331, 335ICAO (air)UN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIIDescription UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol), 9, III Special Provisions A97, A158, A197, A215IATAUN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIITechnical Name EthanolDescription UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol), 9, III Special Provisions A97, A158, A197ERG Code 9LUN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIIEmS-No F-A, S-FSpecial Provisions 274, 335, 969Marine pollutant PDescription UN3082, Environmentally hazardous substance, liquid, n.o.s., 9, III, Marine Pollutant RIDUN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIIClassification code M6Special Provisions 274, 335, 375, 601Description UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol), 9, IIIADRUN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIIClassification code M6Tunnel restriction code (-)Special Provisions 274, 335, 601, 375Description UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol), 9, III, (-) ADNNotes Could not find a Marine Pollutant Name.UN number or ID number UN3082UN proper shipping name Environmentally hazardous substance, liquid, n.o.s.Transport hazard class(es) 9Packing group IIIClassification code M6Special Provisions 274, 335, 375, 601Description UN3082, Environmentally hazardous substance, liquid, n.o.s. (Ethanol, Cobalt), 9, III Equipment Requirements PP15. Regulatory informationInternational InventoriesTSCA -.*Contact supplier for details. One or more substances in this product are either not listed on the US TSCA inventory, listed on the confidential US TSCA inventory or are otherwise exempted from inventory listing requirementsDSL/NDSL -.EINECS/ELINCS -.ENCS -.IECSC -.KECL -.PICCS -.AICS -.Legend:TSCA - United States Toxic Substances Control Act Section 8(b) InventoryDSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances ListEINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical SubstancesENCS - Japan Existing and New Chemical SubstancesIECSC - China Inventory of Existing Chemical SubstancesKECL - Korean Existing and Evaluated Chemical SubstancesPICCS - Philippines Inventory of Chemicals and Chemical SubstancesAICS - Australian Inventory of Chemical SubstancesUS Federal RegulationsSARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard CategoriesShould this product meet EPCRA 311/312 Tier reporting criteria at 40 CFR 370, refer to Section 2 of this SDS for appropriate classifications.CWA (Clean Water Act)This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42).CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this material.US State RegulationsCalifornia Proposition 65This product contains the following Proposition 65 chemicals:.Chemical name California Proposition 65Ethanol - 64-17-5 CarcinogenDevelopmentalCobalt - 7440-48-4 CarcinogenU.S. State Right-to-Know RegulationsChemical name New Jersey Massachusetts Pennsylvania EthanolX X X 64-17-5X X X Cobalt7440-48-4U.S. EPA Label InformationEPA Pesticide Registration Number Not applicable16. Other informationNFPA Health hazards 3 Flammability 1 Instability 0 Special hazards - HMIS Health hazards * 3 Flammability 1 Physical hazards 0 Personal protection X Chronic Hazard Star Legend * = Chronic Health HazardKey or legend to abbreviations and acronyms used in the safety data sheetLegend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTIONTWA Time weighted average STEL Short term exposure limitCeiling Maximum limit value * Skin designationKey literature references and sources for data used to compile the SDSAgency for Toxic Substances and Disease Registry (ATSDR)U.S. Environmental Protection Agency ChemView DatabaseEuropean Food Safety Authority (EFSA)EPA (Environmental Protection Agency)Acute Exposure Guideline Level(s) (AEGL(s))U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide ActU.S. Environmental Protection Agency High Production Volume ChemicalsFood Research JournalHazardous Substance DatabaseInternational Uniform Chemical Information Database (IUCLID)Japan GHS ClassificationAustralia National Industrial Chemicals Notification and Assessment Scheme (NICNAS)NIOSH (National Institute for Occupational Safety and Health)National Library of Medicine's ChemID Plus (NLM CIP)National Library of Medicine’s PubMed database (NLM PUBMED)National Toxicology Program (NTP)New Zealand's Chemical Classification and Information Database (CCID)Organization for Economic Co-operation and Development Environment, Health, and Safety PublicationsOrganization for Economic Co-operation and Development High Production Volume Chemicals ProgramOrganization for Economic Co-operation and Development Screening Information Data SetWorld Health OrganizationRevision Date 2022-12-26Revision Note No information available.DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.End of Safety Data Sheet。
常见细菌中英文对照、菌组、菌属及代码(革兰阴性部分)
产碱杆菌属
axy
-
Alcaligenes xylosoxidans ss. xylosoxidans
木糖氧化无色杆菌木糖氧化亚种
NFR
无色杆菌属
b01
—
Shigella boydii serotype 1
鲍氏志贺菌血清1型
EBC
志贺菌属
b02
-
Shigella boydii serotype 2
鲍氏志贺菌血清2型
EBC
志贺菌属
b03
-
Shigella boydii serotype 3
鲍氏志贺菌血清3型
EBC
志贺菌属
b04
-
Shigella boydii serotype 4
鲍氏志贺菌血清4型
EBC
志贺菌属
b05
—
Shigella boydii serotype 5
鲍氏志贺菌血清5型
EBC
Pasteurella ureae
脲放线杆菌
GNCB
放线杆菌属
ave
-
Aeromonas veronii
维龙气单胞菌
FERM
气单胞菌属
avv
—
Aeromonas veronii biovar veronii
维龙气单胞菌
FERM
气单胞菌属
axy
-
Alcaligenes xylosoxidans
木糖氧化无色杆菌木糖氧化亚种
bud
-
Budvicia sp。
布戴约维采菌属
EBC
布戴约维采菌属
buk
-
Burkholderia sp.
伯克霍尔德菌属
分子生物学词汇(中英文对照表 )
第一页A band|A带A chromosome|A染色体[二倍体染色体组中的正常染色体（不同于B染色体）] A site|[核糖体]A部位ABA|脱落酸abasic site|脱碱基位点，无碱基位点abaxial|远轴的abequose|阿比可糖，beta脱氧岩藻糖aberrant splicing|异常剪接aberration|象差；畸变；失常abiogenesis|自然发生论，无生源论ablastin|抑殖素（抑制微生物细胞分裂或生殖的一种抗体）abnormal distrbution|非正态分布abnormality|异常，失常；畸形，畸变ABO blood group system|ABO血型系统aboriginal mouse|原生鼠abortin|流产素abortion|流产，败育abortive egg|败育卵abortive infection|流产（性）感染abortive transduction|流产（性）转导ABP|肌动蛋白结合蛋白abrin|相思豆毒蛋白abscisic acid|脱落酸abscission|脱落absolute|绝对的absolute configuration|绝对构型absolute counting|绝对测量absolute deviation|绝对偏差absolute error|绝对误差absorbance|吸收，吸光度absorbed dose|吸收剂量absorbent|吸收剂absorptiometer|吸光计absorptiometry|吸光测定法absorption|吸收absorption band|吸收谱带absorption cell|吸收池absorption coefficient|吸收系数absorption spectroscopy|吸收光谱法absorption spectrum|吸收光谱；吸收谱absorptive endocytosis|吸收（型）胞吞（作用） absorptive pinocytosis|吸收（型）胞饮（作用） absorptivity|吸光系数；吸收性abundance|丰度abundant|丰富的，高丰度的abundant mRNAs|高丰度mRNAabzyme|抗体酶acaricidin|杀螨剂accedent variation|偶然变异accelerated flow method|加速流动法accepting arm|[tRNA的]接纳臂acceptor|接纳体，（接）受体acceptor site|接纳位点，接受位点acceptor splicing site|剪接受体acceptor stem|[tRNA的]接纳茎accessible|可及的accessible promoter|可及启动子accessible surface|可及表面accessory|零件，附件；辅助的accessory cell|佐细胞accessory chromosome|副染色体accessory factor|辅助因子accessory nucleus|副核accessory pigment|辅助色素accessory protein|辅助蛋白（质）accommodation|顺应accumulation|积累，累积accuracy|准确度acenaphthene|二氢苊acene|并苯acentric|无着丝粒的acentric fragment|无着丝粒断片acentric ring|无着丝粒环acetal|缩醛acetaldehyde|乙醛acetalresin|缩醛树脂acetamidase|乙酰胺酶acetamide|乙酰胺acetate|乙酸盐acetic acid|乙酸，醋酸acetic acid bacteria|乙酸菌，醋酸菌acetic anhydride|乙酸酐acetification|乙酸化作用，醋化作用acetin|乙酸甘油酯，三乙酰甘油酯acetoacetic acid|乙酰乙酸Acetobacter|醋杆菌属acetogen|产乙酸菌acetogenic bacteria|产乙酸菌acetome body|酮体acetome powder|丙酮制粉[在-30度以下加丙酮制成的蛋白质匀浆物] acetomitrile|乙腈acetone|丙酮acetyl|乙酰基acetyl coenzyme A|乙酰辅酶Aacetylcholine|乙酰胆碱acetylcholine agonist|乙酰胆碱拮抗剂acetylcholine receptor|乙酰胆碱受体acetylcholinesterase|乙酰胆碱酯酶acetylene|乙炔acetylene reduction test|乙炔还原试验[检查生物体的固氮能力] acetylglucosaminidase|乙酰葡糖胺糖苷酶acetylglutamate synthetase|乙酰谷氨酸合成酶acetylsalicylate|乙酰水杨酸；乙酰水杨酸盐、酯、根acetylsalicylic acid|乙酰水杨酸acetylspiramycin|乙酰螺旋霉素AchE|乙酰胆碱酯酶achiral|非手性的acholeplasma|无胆甾原体AchR|乙酰胆碱受体achromatic|消色的；消色差的achromatic color|无色achromatic lens|消色差透镜achromatin|非染色质acid catalysis|酸催化acid fibroblast growth factor|酸性成纤维细胞生长因子acid fuchsin|酸性品红acid glycoprotein|酸性糖蛋白acid hydrolyzed casein|酸水解酪蛋白acid medium|酸性培养基acid mucopolysaccharide|酸性粘多糖acid phosphatase|酸性磷酸酶acid protease|酸性蛋白酶acid solvent|酸性溶剂acidic|酸性的acidic amino acid|酸性氨基酸acidic protein|酸性蛋白质[有时特指非组蛋白]acidic transactivator|酸性反式激活蛋白acidic transcription activator|酸性转录激活蛋白 acidification|酸化（作用）acidifying|酸化（作用）acidolysis|酸解acidophilia|嗜酸性acidophilic bacteria|嗜酸菌acidophilous milk|酸奶aclacinomycin|阿克拉霉素acoelomata|无体腔动物acomitic acid|乌头酸aconitase|顺乌头酸酶aconitate|乌头酸；乌头酸盐、酯、根aconitine|乌头碱aconitum alkaloid|乌头属生物碱ACP|酰基载体蛋白acquired character|获得性状acquired immunity|获得性免疫acridine|吖啶acridine alkaloid|吖啶（类）生物碱acridine dye|吖啶燃料acridine orange|吖啶橙acridine yellow|吖啶黄acriflavine|吖啶黄素acroblast|原顶体acrocentric chromosome|近端着丝染色体acrolein|丙烯醛acrolein polymer|丙烯醛类聚合物acrolein resin|丙烯醛树脂acropetal translocation|向顶运输acrosin|顶体蛋白acrosomal protease|顶体蛋白酶acrosomal reaction|顶体反应acrosome|顶体acrosome reaction|顶体反应acrosomic granule|原顶体acrosyndesis|端部联会acrylamide|丙烯酰胺acrylate|丙烯酸酯、盐acrylic acid|丙烯酸acrylic polymer|丙烯酸（酯）类聚合物acrylic resin|丙烯酸（酯）类树脂acrylketone|丙烯酮acrylonitrile|丙烯腈actidione|放线（菌）酮[即环己酰亚胺]actin|肌动蛋白actin filament|肌动蛋白丝actinin|辅肌动蛋白[分为alfa、beta两种，beta蛋白即加帽蛋白] actinmicrofilament|肌动蛋白微丝actinometer|化学光度计actinomorphy|辐射对称[用于描述植物的花]actinomycetes|放线菌actinomycin D|放线菌素Dactinospectacin|放线壮观素，壮观霉素，奇霉素action|作用action current|动作电流action potential|动作电位action spectrum|动作光谱activated sludge|活性污泥activated support|活化支持体activating group|活化基团activating transcription factor|转录激活因子activation|激活；活化activation analysis|活化分析activation energy|活化能activator|激活物，激活剂，激活蛋白activator protein|激活蛋白active absorption|主动吸收active biomass|活生物质active carbon|活性碳active center|活性中心active chromatin|活性染色质active dry yeast|活性干酵母active dydrogen compounds|活性氢化合物active ester of amino acid|氨基酸的活化酯active hydrogen|活性氢active immunity|主动免疫active oxygen|活性氧active site|活性部位，活性中心active transport|主动转运active uptake|主动吸收activin|活化素[由垂体合成并由睾丸和卵巢分泌的性激素]activity|活性，活度，（放射性）活度actomyosin|肌动球蛋白actophorin|载肌动蛋白[一种肌动蛋白结合蛋白]acute|急性的acute infection|急性感染acute phase|急性期acute phase protein|急性期蛋白，急相蛋白acute phase reaction|急性期反应，急相反应[炎症反应急性期机体的防御反应] acute phase reactive protein|急性期反应蛋白，急相反应蛋白acute phase response|急性期反应，急相反应acute toxicity|急性毒性ACV|无环鸟苷acyclic nucleotide|无环核苷酸acycloguanosine|无环鸟苷，9-（2-羟乙氧甲基）鸟嘌呤acyclovir|无环鸟苷acyl|酰基acyl carrier protein|酰基载体蛋白acyl cation|酰（基）正离子acyl chloride|酰氯acyl CoA|脂酰辅酶Aacyl coenzyem A|脂酰辅酶Aacyl fluoride|酰氟acyl halide|酰卤acylamino acid|酰基氨基酸acylase|酰基转移酶acylating agent|酰化剂acylation|酰化acylazide|酰叠氮acylbromide|酰溴acyloin|偶姻acyltransferase|酰基转移酶adamantanamine|金刚烷胺[曾用作抗病毒剂]adamantane|金刚烷adaptability|适应性adaptation|适应adapter|衔接头；衔接子adapter protein|衔接蛋白质adaptin|衔接蛋白[衔接网格蛋白与其他蛋白的胞质区]adaptive behavior|适应性行为adaptive enzyme|适应酶adaptive molecule|衔接分子adaptive response|适应反应[大肠杆菌中的DNA修复系统]adaptor|衔接头；衔接子adaxial|近轴的addition|加成addition compound|加成化合物addition haploid|附加单倍体addition line|附加系additive|添加物，添加剂additive effect|加性效应additive genetic variance|加性遗传方差additive recombination|插入重组，加插重组[因DNA插入而引起的基因重组] addressin|地址素[选择蛋白(selectin)的寡糖配体，与淋巴细胞归巢有关]adducin|内收蛋白[一种细胞膜骨架蛋白，可与钙调蛋白结合]adduct|加合物，加成化合物adduct ion|加合离子adenine|腺嘌呤adenine arabinoside|啊糖腺苷adenine phosphoribosyltransferase|腺嘌呤磷酸核糖转移酶adenoma|腺瘤adenosine|腺嘌呤核苷，腺苷adenosine deaminase|腺苷脱氨酶adenosine diphoshate|腺苷二磷酸adenosine monophosphate|腺苷（一磷）酸adenosine phosphosulfate|腺苷酰硫酸adenosine triphosphatase|腺苷三磷酸酶adenosine triphosphate|腺苷三磷酸adenovirus|腺病毒adenylate|腺苷酸；腺苷酸盐、酯、根adenylate cyclase|腺苷酸环化酶adenylate energy charge|腺苷酸能荷adenylate kinase|腺苷酸激酶adenylic acid|腺苷酸adenylyl cyclase|腺苷酸环化酶adenylylation|腺苷酰化adherence|粘着，粘附，粘连；贴壁adherent cell|贴壁赴 徽匙牛ㄐ裕┫赴 掣剑ㄐ裕┫赴?/P>adherent culture|贴壁培养adhering junction|粘着连接adhesin|粘附素[如见于大肠杆菌]adhesion|吸附，结合，粘合；粘着，粘附，粘连adhesion factor|粘着因子，粘附因子adhesion molecule|粘着分子，粘附分子adhesion plaque|粘着斑adhesion protein|粘着蛋白，吸附蛋白adhesion receptor|粘着受体adhesion zone|粘着带[如见于细菌壁膜之间]adhesive|粘合剂，胶粘剂adhesive glycoprotein|粘着糖蛋白adipic acid|己二酸，肥酸adipocyte|脂肪细胞adipokinetic hormone|脂动激素[见于昆虫]adipose tissue|脂肪组织adjust|[动]调节，调整；修正adjustable|可调的adjustable miropipettor|可调微量移液管adjustable spanner|活动扳手adjusted retention time|调整保留时间adjusted retention volume|调整保留体积adjuvant|佐剂adjuvant cytokine|佐剂细胞因子adjuvant peptide|佐剂肽adjuvanticity|佐剂（活）性adoptive immunity|过继免疫adoptive transfer|过继转移ADP ribosylation|ADP核糖基化ADP ribosylation factor|ADP核糖基化因子ADP ribosyltransferase|ADP核糖基转移酶adrenal cortical hormone|肾上腺皮质(激)素adrenaline|肾上腺素adrenergic receptor|肾上腺素能受体adrenocepter|肾上腺素受体adrenocorticotropic hormone|促肾上腺皮质(激)素adrenodoxin|肾上腺皮质铁氧还蛋白adriamycin|阿霉素，亚德里亚霉素adsorbent|吸附剂adsorption|吸附adsorption catalysis|吸附催化adsorption center|吸附中心adsorption chromatography|吸附层析adsorption film|吸附膜adsorption isobar|吸附等压线adsorption isotherm|吸附等温线adsorption layer|吸附层adsorption potential|吸附电势adsorption precipitation|吸附沉淀adsorption quantity|吸附量adult diarrhea rotavirus|成人腹泻轮状病毒advanced glycosylation|高级糖基化advanced glycosylation end product|高级糖基化终产物 adventitious|不定的，无定形的adverse effect|反效果，副作用aecidiospore|锈孢子，春孢子aeciospore|锈孢子，春孢子aequorin|水母蛋白，水母素aeration|通气aerator|加气仪，加气装置aerial mycelium|气生菌丝体aerobe|需氧菌[利用分子氧进行呼吸产能并维持正常生长繁殖的细菌] aerobic|需氧的aerobic bacteria|需氧（细）菌aerobic cultivation|需氧培养aerobic glycolysis|有氧酵解aerobic metabolism|有氧代谢aerobic respiration|需氧呼吸aerobic waste treatment|需氧废物处理aerobiosis|需氧生活aerogel|气凝胶aerogen|产气菌aerolysin|气单胞菌溶素Aeromonas|气单胞菌属aerosol|气溶胶aerosol gene delivery|气溶胶基因送递aerospray ionization|气喷射离子化作用aerotaxis|趋氧性[（细胞）随环境中氧浓度梯度进行定向运动]aerotolerant bacteria|耐氧菌[不受氧毒害的厌氧菌]aerotropism|向氧性aesculin|七叶苷，七叶灵aetiology|病原学B cell|B细胞B cell antigen receptor|B细胞抗原受体B cell differentiation factor|B细胞分化因子B cell growth factor|B细胞生长因子B cell proliferation|B细胞增殖B cell receptor|B细胞受体B cell transformation|B细胞转化B chromosome|B染色体[许多生物（如玉米）所具有的异染质染色体] B to Z transition|B-Z转换[B型DNA向Z型DNA转换]Bacillariophyta|硅藻门Bacillus|芽胞杆菌属Bacillus anthracis|炭疽杆菌属Bacillus subtillis|枯草芽胞杆菌bacitracin|杆菌肽back donation|反馈作用back flushing|反吹，反冲洗back mutation|回复突变[突变基因又突变为原由状态]backbone|主链；骨架backbone hydrogen bond|主链氢键backbone wire model|主链金属丝模型[主要反应主链走向的实体模型]backcross|回交backflushing chromatography|反吹层析，反冲层析background|背景，本底background absorption|背景吸收background absorption correction|背景吸收校正background correction|背景校正background gactor|背景因子background genotype|背景基因型[与所研究的表型直接相关的基因以外的全部基因]background hybridization|背景杂交background radiation|背景辐射，本底辐射backmixing|反向混合backside attack|背面进攻backward reaction|逆向反应backwashing|反洗bacmid|杆粒[带有杆状病毒基因组的质粒，可在细菌和昆虫细胞之间穿梭]bacteremia|菌血症bacteria|（复）细菌bacteria rhodopsin|细菌视紫红质bacterial adhesion|细菌粘附bacterial alkaline phosphatase|细菌碱性磷酸酶bacterial artificial chromosome|细菌人工染色体bacterial colony|（细菌）菌落bacterial colony counter|菌落计数器bacterial conjugation|细菌接合bacterial filter|滤菌器bacterial invasion|细菌浸染bacterial motility|细菌运动性bacterial rgodopsin|细菌视紫红质，细菌紫膜质bacterial vaccine|菌苗bacterial virulence|细菌毒力bactericidal reaction|杀（细）菌反应bactericide|杀（细）菌剂bactericidin|杀（细）菌素bactericin|杀（细）菌素bacteriochlorophyll|细菌叶绿素bacteriochlorophyll protein|细菌叶绿素蛋白bacteriocide|杀（细）菌剂bacteriocin|细菌素bacteriocin typing|细菌素分型[利用细菌素对细胞进行分型]bacterioerythrin|菌红素bacteriofluorescein|细菌荧光素bacteriology|细菌学bacteriolysin|溶菌素bacteriolysis|溶菌（作用）bacteriolytic reaction|溶菌反应bacteriophaeophytin|细菌叶褐素bacteriophage|噬菌体bacteriophage arm|噬菌体臂bacteriophage conversion|噬菌体转变bacteriophage head|噬菌体头部bacteriophage surface expression system|噬菌体表面表达系统bacteriophage tail|噬菌体尾部bacteriophage typing|噬菌体分型bacteriophagology|噬菌体学bacteriopurpurin|菌紫素bacteriorhodopsin|细菌视紫红质bacteriosome|细菌小体[昆虫体内一种含有细菌的结构]bacteriostasis|抑菌(作用)bacteriostat|抑菌剂bacteriotoxin|细菌毒素bacteriotropin|亲菌素bacterium|细菌bacteroid|类菌体baculovirus|杆状病毒bag sealer|封边机baking soda|小苏打BAL 31 nuclease|BAL 31核酸酶balance|天平balanced heterokaryon|平衡异核体balanced lethal|平衡致死balanced lethal gene|平衡致死基因balanced linkage|平衡连锁balanced pathogenicity|平衡致病性balanced polymorphism|平衡多态性balanced salt solution|平衡盐溶液balanced solution|平衡溶液balanced translocation|平衡易位balbaini ring|巴尔比亚尼环[由于RNA大量合成而显示特别膨大的胀泡，在多线染色体中形成独特的环]Balbiani chromosome|巴尔比亚尼染色体[具有染色带的多线染色体，1881年首先发现于双翅目摇蚊幼虫]ball mill|球磨ball mill pulverizer|球磨粉碎机ball milling|球磨研磨balloon catheter|气囊导管[可用于基因送递，如将DNA导入血管壁]banana bond|香蕉键band|条带，带[见于电泳、离心等]band broadening|条带加宽band sharpening|条带变细，条带锐化band width|带宽banding pattern|带型banding technique|显带技术,分带技术barbiturate|巴比妥酸盐barium|钡barly strip mosaic virus|大麦条纹花叶病毒barly yellow dwarf virus|大麦黄矮病毒barnase|芽胞杆菌RNA酶[见于解淀粉芽胞杆菌]barophilic baceria|嗜压菌baroreceptor|压力感受器barotaxis|趋压性barotropism|向压性barr body|巴氏小体barrel|桶，圆筒[可用于描述蛋白质立体结构，如beta折叠桶]barrier|屏障，垒barstar|芽胞杆菌RNA酶抑制剂[见于解淀粉芽胞杆菌]basal|基础的，基本的basal body|基粒basal body temperature|基础体温basal component|基本成分，基本组分basal expression|基础表达，基态表达basal granule|基粒basal heat producing rate|基础产热率basal lamina|基膜，基板basal level|基础水平，基态水平basal medium|基本培养基，基础培养基basal medium Eagle|Eagle基本培养基basal metabolic rate|基础代谢率basal metabolism|基础代谢basal promoter element|启动子基本元件basal transcription|基础转录，基态转录basal transcription factor|基础转录因子base|碱基；碱base analog|碱基类似物，类碱基base catalysis|碱基催化base composition|碱基组成base pairing|碱基配对base pairing rules|碱基配对法则,碱基配对规则base peak|基峰base pire|碱基对base ratio|碱基比base stacking|碱基堆积base substitution|碱基置换baseline|基线baseline drift|基线漂移baseline noise|基线噪声basement membrane|基底膜basement membrane link protein|基底膜连接蛋白basic amino acid|碱性氨基酸basic fibroblast growth factor|碱性成纤维细胞生长因子basic fuchsin|碱性品红basic medium|基础培养基basic number of chromosome|染色体基数basic protein|碱性蛋白质basic solvent|碱性溶剂basic taste sensation|基本味觉basidiocarp|担子果basidiomycetes|担子菌basidium|担子basipetal translocation|向基运输basket centrifuge|（吊）篮式离心机basket drier|篮式干燥机basket type evaporator|篮式蒸发器basonuclin|碱（性）核蛋白[见于角质形成细胞，含有多对锌指结构] basophil|嗜碱性细胞basophil degranulation|嗜碱性细胞脱粒basophilia|嗜碱性batch|分批；批，一批batch cultivation|分批培养batch culture|分批培养物batch digestor|分批消化器batch extraction|分批抽提，分批提取batch fermentation|分批发酵，（罐）批发酵batch filtration|分批过滤batch operation|分批操作batch process|分批工艺，分批法batch reactor|间歇反应器，分批反应器batch recycle cultivation|分批再循环培养batch recycle culture|分批再循环培养（物）bathochrome|向红基bathochromic shift|红移bathorhodopsin|红光视紫红质，前光视紫红质batrachotoxin|树蛙毒素[固醇类生物碱，作用于钠通道] baytex|倍硫磷BCG vaccine|卡介苗bead mill|玻珠研磨机bead mill homogenizer|玻珠研磨匀浆机bean sprouts medium|豆芽汁培养基beauvericin|白僵菌素becquerel|贝可（勒尔）bed volume|（柱）床体积bee venom|蜂毒beef broth|牛肉汁beef extract|牛肉膏，牛肉提取物beet yellows virus|甜菜黄化病毒Beggiatoa|贝日阿托菌属[属于硫细菌]behavior|行为；性质，性能behavioral control|行为控制behavioral isolation|行为隔离behavioral thermoregulation|行为性体温调节behenic acid|山yu酸，二十二（烷）酸belt desmosome|带状桥粒belt press|压带机belt press filter|压带（式）滤器bench scale|桌面规模，小试规模benchtop bioprocessing|桌面生物工艺[小试规模]benchtop microcentrifuge|台式微量离心机bend|弯曲；弯管；转折bending|弯曲；转折，回折beneficial element|有益元素bent bond|弯键bent DNA|弯曲DNA,转折DNAbenzene|苯benzhydrylamine resin|二苯甲基胺树脂benzidine|联苯胺benzilate|三苯乙醇酸（或盐或酯）benzimidazole|苯并咪唑benzodiazine|苯并二嗪，酞嗪benzoin|苯偶姻，安息香benzophenanthrene|苯并菲benzopyrene|苯并芘benzoyl|苯甲酰基benzoylglycine|苯甲酰甘氨酸benzyl|苄基benzyladenine|苄基腺嘌呤benzylaminopurine|苄基氨基嘌呤benzylisoquinoline|苄基异喹啉benzylisoquinoline alkaloid|苄基异喹啉（类）生物碱benzylpenicillin|苄基青霉素berberine|小檗碱Bertrand rule|贝特朗法则bestatin|苯丁抑制素[可抑制亮氨酸氨肽酶的一种亮氨酸类似物]C value|C值[单倍基因组DNA的量]C value paradox|C值悖理[物种的C值和它的进化复杂性之间无严格对应关系]C4 dicarboxylic acid cycle|C4二羧酸循环cachectin|恶液质素[即alfa肿瘤坏死因子]cadaverine|尸胺cadherin|钙粘着蛋白[介导依赖（于）钙的细胞间粘着作用的一类跨膜蛋白质，分为E-,N-,P-等若干种，E表示上皮（epithelia)，N表示神经（neural），P表示胎盘（placental）] cadmium|镉caerulin|雨蛙肽cage|笼cage compound|笼形化合物cage coordination compound|笼形配合物cage effect|笼效应cage structure|笼形结构[非极性分子周围的水分子所形成的有序结构]calbindin|钙结合蛋白calciferol|麦角钙化（固）醇calcimedin|钙介蛋白[钙调蛋白拮抗剂]calcineurin|钙调磷酸酶[依赖于钙调蛋白的丝氨酸—苏氨酸磷酸酶]calcionin|降钙素calcium binding protein|钙结合蛋白（质）calcium binding site|钙结合部位calcium channel|钙通道calcium chloride|氯化钙calcium influx|钙流入calcium mediatory protein|钙中介蛋白（质）calcium phosphate|磷酸钙calcium phosphate precipitation|磷酸盐沉淀calcium pump|钙泵calcium sensor protein|钙传感蛋白（质）calcium sequestration|集钙（作用）calcyclin|钙（细胞）周边蛋白calcyphosine|钙磷蛋白[是依赖于cAMP的蛋白激酶的磷酸化底物]caldesmon|钙调（蛋白）结合蛋白[主要见于平滑肌，可与钙调蛋白及肌动蛋白结合] calelectrin|钙电蛋白[最初发现于鳗鱼电器官的一种钙结合蛋白]calf intestinal alkaline phosphatase|（小）牛小肠碱性磷酸酶calf serum|小牛血清calf thymus|小牛胸腺calgranulin|钙粒蛋白calibration|校准，标准calibration curve|校正曲线calibration filter|校准滤光片calibration protein|校准蛋白calicheamycin|刺孢霉素[来自刺孢小单胞菌的抗肿瘤抗生素，带有二炔烯官能团] calicivirus|杯状病毒calli|（复）胼胝体，愈伤组织[用于植物]；胼胝[见于动物皮肤]callose|胼胝质，愈伤葡聚糖callose synthetase|愈伤葡聚糖合成酶callus|胼胝体，愈伤组织[用于植物]；胼胝[见于动物皮肤]callus culture|愈伤组织培养calmodulin|钙调蛋白calnexin|钙联结蛋白[内质网的一种磷酸化的钙结合蛋白]calomel|甘汞calomel electrode|甘汞电极calorie|卡calpactin|依钙（结合）蛋白[全称为“依赖于钙的磷脂及肌动蛋白结合蛋白”]calpain|（需）钙蛋白酶calpain inhibitor|（需）钙蛋白酶抑制剂calpastatin|(需）钙蛋白酶抑制蛋白calphobindin|钙磷脂结合蛋白calphotin|钙感光蛋白[感光细胞的一种钙结合蛋白]calprotectin|（肌）钙网蛋白[骨骼肌肌质网膜上的钙结合蛋白]calretinin|钙（视）网膜蛋白calsequestrin|（肌）集钙蛋白calspectin|钙影蛋白calspermin|钙精蛋白[睾丸的一种钙调蛋白结合蛋白]caltractin|钙牵蛋白[一种与基粒相关的钙结合蛋白]Calvin cycle|卡尔文循环，光合碳还原环calyculin|花萼海绵诱癌素[取自花萼盘皮海绵的磷酸酶抑制剂]calyptra|根冠calyx|花萼cambium|形成层[见于植物]cAMP binding protein|cAMP结合蛋白cAMP receptor protein|cAMP受体蛋白cAMP response element|cAMP效应元件cAMP response element binding protein|cAMP效应元件结合蛋白Campbell model|坎贝尔模型camphane|莰烷camphane derivative|莰烷衍生物camphore|樟脑camptothecin|喜树碱Campylobacter|弯曲菌属Campylobacter fetus|胎儿弯曲菌属Canada balsam|加拿大香脂，枞香脂canaline|副刀豆氨酸canalization|[表型]限渠道化，发育稳态[尽管有遗传因素和环境条件的干扰，表型仍保持正常]canavanine|刀豆氨酸cancer|癌症cancer metastasis|癌症转移cancer suppressor gene|抑癌基因cancer suppressor protein|抑癌基因产物，抑癌蛋白（质）candicidin|杀假丝菌素candida|念珠菌属Candida albicans|白色念珠菌candle jar|烛罐cannabin|大麻苷；大麻碱canonical base|规范碱基canonical molecular orbital|正则分子轨道canonical partition function|正则配分函数canonical sequence|规范序列cantharidin|斑蝥素canthaxanthin|角黄素canyon|峡谷[常用于比喻某些生物大分子的主体结构特征]cap|帽，帽（结构）cap binding protein|帽结合蛋白cap site|加帽位点capacitation|获能[特指镜子在雌性生殖道中停留后获得使卵子受精的能力]capacity|容量capacity factor|容量因子capillarity|毛细现象capillary|毛细管；毛细血管capillary absorption|毛细吸收capillary action|毛细管作用capillary attraction|毛细吸力capillary column|毛细管柱capillary culture|毛细管培养capillary electrode|毛细管电极capillary electrophoresis|毛细管电泳capillary free electrophoresis|毛细管自由流动电泳capillary gas chromatography|毛细管气相层析capillary isoelectric focusing|毛细管等电聚焦capillary isotachophoresis|毛细管等速电泳capillary membrane module|毛细管膜包capillary transfer|毛细管转移[通过毛细管作用进行核酸的印迹转移] capillary tube|毛细管capillary tubing|毛细管capillary zone electrophoresis|毛细管区带电泳capillovirus|毛状病毒组capping|加帽，加帽反应；封闭反应；帽化，成帽capping enzyme|加帽酶capping protein|[肌动蛋白]加帽蛋白caprin|癸酸甘油酯caproin|己酸甘油酯capromycin|卷曲霉素，缠霉素caproyl|己酸基caprylin|辛酸甘油酯capsid|（病毒）衣壳，（病毒）壳体capsid protein|衣壳蛋白capsidation|衣壳化capsomer|（病毒）壳粒capsular polysaccharide|荚膜多糖capsulation|包囊化（作用），胶囊化（作用）capsule|荚膜capsule swelling reaction|荚膜肿胀反应capture|捕捉，俘获capture antigen|捕捉抗原[酶免疫测定中用于捕捉抗体的抗原]capture assay|捕捉试验carbamyl|氨甲酰基carbamyl ornithine|氨甲酰鸟氨酸carbamyl phosphate|氨甲酰磷酸carbamyl phosphate synthetase|氨甲酰磷酸合成酶carbamyl transferase|氨甲酰（基）转移酶carbamylation|氨甲酰化carbanion|碳负离子carbanyl group|羰基carbene|卡宾carbenicillin|羧苄青霉素carbenoid|卡宾体carbocation|碳正离子carbodiimide|碳二亚胺carbohydrate|糖类，碳水化合物carbohydrate fingerprinting|糖指纹分析carbohydrate mapping|糖作图，糖定位carbohydrate sequencing|糖测序carbol fuchsin|石炭酸品红carboline|咔啉，二氮芴carbon assimilation|碳同化carbon balance|碳平衡carbon cycling|碳循环carbon dioxide|二氧化碳carbon dioxide compensation|二氧化碳补偿点carbon dioxide fertilization|二氧化碳施肥carbon dioxide fixation|二氧化碳固定carbon dioxide tension|二氧化碳张力carbon fiber|碳纤维carbon fixation|碳固定carbon isotope|碳同位素carbon isotope analysis|碳同位素分析carbon isotope composition|碳同位素组成carbon monoxide|一氧化碳carbon source|碳源carbonate|碳酸盐，碳酸酯carbonate plant|碳化植物carbonic anhydrase|碳酸酐酶carbonium ion|碳正离子carbonyl|羰基carbonylation|羰基化carboxydismutase|羰基岐化酶，核酮糖二磷酸羧化酶 carboxydotrophic bacteria|一氧化碳营养菌carboxyglutamic acid|羧基谷氨酸carboxyl|羧基carboxyl protease|羧基蛋白酶carboxyl terminal|羧基端carboxyl transferase|羧基转移酶carboxylase|羧化酶carboxylation|羧（基）化carboxylic acid|羧酶carboxymethyl|羧甲基carboxymethyl cellulose|羧甲基纤维素carboxypeptidase|羧肽酶[包括羧肽酶A、B、N等]carcinogen|致癌剂carcinogenesis|致癌，癌的发生carcinogenicity|致癌性carcinoma|癌carcinostatin|制癌菌素cardenolide|强心苷cardiac aglycone|强心苷配基，强心苷元cardiac cycle|心动周期cardiac glycoside|强心苷cardiac receptor|心脏感受器cardiohepatid toxin|心肝毒素[如来自链球菌]cardiolipin|心磷脂cardiotoxin|心脏毒素cardiovascular center|心血管中枢cardiovascular disease|心血管疾病cardiovirus|心病毒属[模式成员是脑心肌炎病毒]carlavirus|香石竹潜病毒组carmine|洋红carminomycin|洋红霉素carmovirus|香石竹斑驳病毒组carnation latent virus|香石竹潜病毒carnation mottle virus|香石竹斑驳病毒carnation ringspot virus|香石竹环斑病毒carnitine|肉碱carnitine acyl transferase|肉碱脂酰转移酶carnosine|肌肽[即beta丙氨酰组氨酸]carotene|胡萝卜素carotene dioxygenase|胡萝卜素双加氧酶carotenoid|类胡萝卜素carotenoprotein|胡萝卜素蛋白carpel|[植物]心皮carrageen|角叉菜，鹿角菜carrageenin|角叉菜胶carrier|载体，运载体，携载体；携带者，带（病）毒者，带菌者 carrier ampholyte|载体两性电解质carrier catalysis|载体催化carrier coprecipitation|载体共沉淀carrier DNA|载体DNAcarrier free|无载体的carrier phage|载体噬菌体carrier precipitation|载体沉淀（作用）carrier state|携带状态carriomycin|腐霉素，开乐霉素cartridge|[萃取柱的]柱体；软片，胶卷；子弹，弹药筒casamino acid|（水解）酪蛋白氨基酸，酪蛋白水解物cascade|串联，级联，级联系统cascade amplification|级联放大cascade chromatography|级联层析cascade fermentation|级联发酵casein|酪蛋白，酪素casein kinase|酪蛋白激酶[分I、II两种]Casparian band|凯氏带[见于植物内表皮细胞]Casparian strip|凯氏带cassette|盒，弹夹[借指DNA序列组件]cassette mutagenesis|盒式诱变casting|铸，灌制CAT box|CAT框[真核生物结构基因上游的顺式作用元件]catabolism|分解代谢catabolite gene activator protein|分解代谢物基因激活蛋白 catabolite repression|分解代谢物阻抑，分解代谢产物阻遏catalase|过氧化氢酶catalytic active site|催化活性位catalytic activity|催化活性catalytic antibody|催化性抗体，具有催化活性的抗体catalytic constant|催化常数[符号Kcat]catalytic core|催化核心catalytic mechanism|催化机理catalytic RNA|催化性RNAcatalytic selectivity|催化选择性catalytic site|催化部位catalytic subunit|催化亚基cataphoresis|阳离子电泳cataract|白内障catechin|儿茶素catechol|儿茶酚，邻苯二酚catecholamine|儿茶酚胺catecholamine hormones|儿茶酚胺类激素catecholaminergic recptor|儿茶酚胺能受体catenane|连环（体），连锁，链条[如DNA连环体]；索烃catenating|连环，连接catenation|连环，连锁，成链catenin|连环蛋白[一类细胞骨架蛋白，分alfa/beta/gama三种] catharanthus alkaloid|长春花属生物碱cathepsin|组织蛋白酶[分为A、B、C、D、E…H、L等多种]catheter|导管cathode layer enrichment method|阴极区富集法cathode ray polarograph|阴极射线极谱仪cation acid|阳离子酸cationic acid|阳离子酸cationic catalyst|正离子催化剂cationic detergent|阳离子（型）去污剂cationic initiator|正离子引发剂cationic polymerization|正离子聚合，阳离子聚合 cationic surfactant|阳离子（型）表面活性剂cationization|阳离子化cauliflower mosaic virus|花椰菜花叶病毒caulimovirus|花椰菜花叶病毒组caulobacteria|柄病毒Cavendish laboratory|（英国）卡文迪什实验室caveola|小窝，小凹caveolae|(复）小窝，小凹caveolin|小窝蛋白cavitation|空腔化（作用）cavity|沟槽，模槽，空腔dammarane|达玛烷dammarane type|达玛烷型Dane particle|丹氏粒[乙型肝炎病毒的完整毒粒]dansyl|丹（磺）酰，1-二甲氨基萘-5-磺酰dansyl chloride|丹磺酰氯dansyl method|丹磺酰法dantrolene|硝苯呋海因[肌肉松弛剂]dark current|暗电流dark field|暗视野，暗视场dark field microscope|暗视野显微镜，暗视场显微镜 dark field microscopy|暗视野显微术，暗视场显微术 dark reaction|暗反应dark repair|暗修复dark respiration|暗呼吸dark room|暗室，暗房dark seed|需暗种子data accumulation|数据积累data acquisition|数据获取data analysis|数据分析data bank|数据库data base|数据库data handling|数据处理data logger|数据记录器data logging|数据记录data output|数据输出data processing|数据处理data recording|数据记录dauermodification|持续饰变daughter cell|子代细胞daughter chromatid|子染色单体daughter chromosome|子染色体daughter colony|子菌落[由原生菌落续发生长的小菌落]daunomycin|道诺霉素daunorubicin|道诺红菌素de novo sequencing|从头测序de novo synthesis|从头合成deactivation|去活化（作用），失活（作用），钝化deacylated tRNA|脱酰tRNAdead time|死时间dead volume|死体积deadenylation|脱腺苷化DEAE Sephacel|[商]DEAE-葡聚糖纤维素，二乙氨乙基葡聚糖纤维素 dealkylation|脱烷基化deaminase|脱氨酶deamination|脱氨（基）death phase|死亡期[如见于细胞生长曲线]death point|死点deblocking|去封闭debranching enzyme|脱支酶，支链淀粉酶debris|碎片，残渣decahedron|十面体decane|癸烷decantation|倾析decanting|倾析decapacitation|去（获）能decarboxylase|脱羧酶decarboxylation|脱羧（作用）decay|原因不明腐败decay accelerating factor|衰变加速因子decay constant|衰变常数deceleration phase|减速期[如见于细胞生长曲线]dechlorination|脱氯作用deciduous leaf|落叶decline phase|[细胞生长曲线的]衰亡期decoagulant|抗凝剂decoding|译码，解码decomposer|分解者[可指具有分解动植物残体或其排泄物能力的微生物] decompression|降压，减压decondensation|解凝（聚）decontaminant|净化剂，去污剂decontaminating agent|净化剂，去污剂decontamination|净化，去污decorin|核心蛋白聚糖[一种基质蛋白聚糖，又称为PG-40]dedifferentiation|去分化，脱分化deep colony|深层菌落deep etching|深度蚀刻deep jet fermentor|深部喷注发酵罐deep refrigeration|深度冷冻deep shaft system|深井系统[如用于污水处理]defasciculation factor|解束因子[取自水蛭，可破坏神经束]defective|缺损的，缺陷的defective interfering|缺损干扰defective interfering particle|缺损干扰颗粒，干扰缺损颗粒defective interfering RNA|缺损干扰RNAdefective interfering virus|缺损干扰病毒defective mutant|缺损突变体，缺陷突变型，缺陷突变株defective phage|缺损噬菌体，缺陷噬菌体defective virus|缺损病毒，缺陷病毒defense|防御，防卫defense peptide|防卫肽defense response|防御反应，防卫反应defensin|防卫素[动物细胞的内源性抗菌肽]deficiency|缺乏，缺损，缺陷deficient|缺少的，缺损的，缺陷的defined|确定的defined medium|确定成分培养基，已知成分培养液defintion|定义defoliating agent|脱叶剂defoliation|脱叶deformylase|去甲酰酶[见于原核细胞，作用于甲酰甲硫氨酸]degasser|脱气装置degassing|脱气，除气degeneracy|简并；简并性，简并度degenerate|简并的degenerate codon|简并密码子degenerate oligonucleotide|简并寡核苷酸degenerate primer|简并引物degenerate sequence|简并序列degeneration|退化，变性degenerin|退化蛋白[与某些感觉神经元的退化有关]deglycosylation|去糖基化degradable polymer|降解性高分子degradation|降解degranulation|脱（颗）粒（作用）degree of acidity|酸度degree of dominance|显性度degree of polymerization|聚合度degron|降解决定子[决定某一蛋白发生降解或部分降解的序列要素] deguelin|鱼藤素dehalogenation|脱卤（作用）dehardening|解除锻炼dehumidifier|除湿器dehydratase|脱水酶dehydrated medium|干燥培养基dehydration|脱水（作用）dehydroepiandrosterone|脱氢表雄酮dehydrogenase|脱氢酶dehydrogenation|脱氢（作用）dehydroluciferin|脱氢萤光素deionization|去离子（作用）deionized|去离子的deionized water|去离子水deionizing|去离子（处理）delayed early transcription|（延）迟早期转录[可特指病毒]delayed fluorescence|延迟荧光delayed heat|延迟热delayed hypersensitivity|延迟（型）超敏反应delayed ingeritance|延迟遗传delayed type hypersensitivity|迟发型超敏反应deletant|缺失体deletion|缺失deletion mapping|缺失定位，缺失作图deletion mutagenesis|缺失诱变deletion mutant|缺失突变体deletion mutantion|缺失突变deletional recombination|缺失重组delignification|脱木质化（作用）deliquescence|潮解delivery flask|分液瓶delocalized bond|离域键。
原发性胆囊癌的早期诊断
原发性胆囊癌的早期诊断殷保兵【摘要】原发性胆囊癌是胆道常见恶性肿瘤，恶性程度高，发现时往往伴有肝脏转移，预后极差。
掌握原发性胆囊癌的高危因素，对胆囊癌高危人群进行密切随访和筛选，可提高原发性胆囊癌的早期诊断率，对改善胆囊癌的预后有重大意义。
%Primary gallbladder carcinoma (PGC) is the common malignant tumour in biliary tract and is associated with poor prognosis in patients with liver metastasis. It is important to understand the high risk factors of PGC, and closely follow up and screen the high-risk populations in order to improve the early diagnosis of gallbladder cancer and its prognosis.【期刊名称】《上海医药》【年(卷),期】2014(000)014【总页数】3页(P12-14)【关键词】胆囊癌;早期诊断;高危人群【作者】殷保兵【作者单位】复旦大学附属华山医院外科上海 200040【正文语种】中文【中图分类】R735.8原发性胆囊癌是最常见的胆道恶性肿瘤，约占消化道恶性肿瘤的第6位[1-2]。
2007年上海市胆囊癌发病率男性为5.90/10万，女性为10.22/10万，而同期全国胆囊癌死亡率高达4.07/10万[3-4]。
邹声泉等[5]报道2000年我国大陆原发性胆囊癌发病率占同期胆道疾病的0.4%～3.8%。
近年来，胆囊癌的发病率有上升趋势，而发病年龄则呈下降趋势。
胆囊癌的早期诊断非常困难，而其恶性程度极高，且易转移复发，因此预后极差，进展期胆囊癌的中位生存期仅6个月，5年生存率仅为5%[2]。
安捷伦产品目录
15
Real-Time PCR
16
Mx3000P QPCR System
17
Brilliant III Ultra-Fast SYBR Green QPCR and QRT-PCR Reagents
18
Brilliant III Ultra-Fast QPCR and QRT-PCR Reagents
Agilent / STRATAGENE
Agilent website: /genomics
Welgene | Agilent Stratagene
威健股份有限公司 | Stratagene 總代理
Table of Content
Table of Contents
/ XL1-Red Competent Cells SoloPack Gold Supercompetent Cells
/ TK Competent Cells Specialty Cells
/ Classic Cells / Fine Chemicals For Competent Cells
適用於 UNG 去汙染或 bisulphite
sequencing
適用於 TA Cloning
最高敏感性
取代傳統 Taq 的好選擇
-
2
威健股份有限公司 | Stratagene 總代理
PCR Enzyme & Instrument
Agilent SureCycler 8800
市場上領先的 cycling 速度和 sample 體積 10 ～ 100 μL 簡易快速可以選擇 96 well 和 384 well 操作盤 優秀的溫控設備讓各個 well 都能保持溫度的穩定 七吋的高解析度觸控螢幕讓操作上更為簡便 可以透過網路遠端操控儀器及監控儀器 Agilent 專業的技術支援可以幫助您應對各種 PCR 的問題
BDPharmingen
BD Pharmingen™Technical Data SheetPurified Mouse Anti-Rat Macrophage ActivatorProduct InformationMaterial Number:555020Alternate Name: RMASize: 0.5 mgConcentration:0.5 mg/mlClone: anti-RMAImmunogen:Activated Lewis rat alveolar macrophagesIsotype:Mouse (BALB/c X C57BL/6) IgG1, κQC Testing: RatReactivity:Aqueous buffered solution containing ≤0.09% sodium azide.Storage Buffer:DescriptionThe anti-RMA antibody reacts with a 120-kDa cell-surface antigen, which is found on tissue macrophages, resident alveolar macrophages,thioglycollate-elicited peritoneal exudate cells, a subset of peripheral blood monocytes, and a small subset of pulmonary interstitial dendriticcells. mAb anti-RMA activates DNA and protein synthesis and promotes fusion of alveolar macrophages to form multinucleated giant cells.Two-color analysis of Macrophage Activator antigenexpression on peripheral blood monocytes.Lewis ratperipheral blood leukocytes were incubated simultaneouslywith FITC-conjugated anti-rat CD11b mAb WT.5 (Cat. no.554982) and purified mAb anti-RMA. The purified antibodywas detected with biotinylated anti-mouse IgG1 mAb A85-1(Cat. no. 553441), followed by Streptavidin-PE (Cat. no.554061). Mononuclear cells were selected according totheir forward vs. side-scatter profile. Flow cytometry wasperformed on a BD FACScan™ flow cytometry system.Preparation and StorageThe monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.Application NotesApplicationFlow cytometry Routinely TestedImmunohistochemistry-frozen ReportedImmunoprecipitation ReportedWestern blot Not RecommendedImmunohistochemistry-paraffin Not RecommendedSuggested Companion ProductsCatalog Number Size CloneName554982FITC Mouse Anti-Rat CD11b0.5 mg WT.5 553441Biotin Rat Anti-Mouse IgG10.5 mg A85-1 554061PE Streptavidin0.5 mg(none) 557273Purified Mouse IgG1, κ Isotype Control0.5 mg MOPC-31C Product Notices1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.2.Please refer to /pharmingen/protocols for technical protocols.3.Sodium azide is a reversible inhibitor of oxidative metabolism; therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. Since endotoxin may also affect the results of functional studies, we recommend the NA/LE (No Azide/Low Endotoxin) antibody format, if available, for in vitro and in vivo use.4.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.ReferencesLazarus D, Yamin M, McCarthy K, Schneeberger EE, Kradin R. Anti-RMA, a murine monoclonal antibody, activates rat macrophages: II. Induction of DNA synthesis and formation of multinucleated giant cells.. Am J Respir Cell Mol Biol. 1990; 3(2):103-111.(Clone-specific: Activation)Xia WJ, Schneeberger EE, McCarthy K, Kradin RL. Accessory cells of the lung. II. Ia+ pulmonary dendritic cells display cell surface antigen heterogeneity. Am J Respir Cell Mol Biol. 1991; 5(3):276-283.(Biology)Yamin M, Lazarus D, Schneeberger EE, McCarthy K, Xia WJ, Kradin R. Anti-RMA: a murine monoclonal antibody that activates rat macrophages. I. Distribution and characterization of the RMA antigen. Cell Mol Biol (Noisy-le-grand). 1990; 2:207-215.(Immunogen: Activation, Immunohistochemistry, Immunoprecipitation, Western blot)。
Calcipotriol_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Sep.-13-2017Print Date:Sep.-13-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :CalcipotriolCatalog No. :HY-10001CAS No. :112965-21-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:MC 903; CalcipotrieneFormula:C27H40O3Molecular Weight:412.60CAS No. :112965-21-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature: 4°C, protect from light, stored under nitrogenShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
喹诺酮参数
分子式:C17H19F2N3O3
分子量:351.35
从乙醇中得到无色针状结晶，熔点239～240.5℃。急性毒性50小鼠(mg/kg)：245.6静脉注射；＞4000口服。
盐酸洛美沙星(Lomeflocacin Hydrochoride)：C17H19F2N3O3?HCl。[98079-52-8]。从水中得到无色针状结晶，熔点290～300℃(分解)。
水溶解性Soluble in acetic acid or water. Slightly soluble in methanol
培氟沙星/甲氟哌酸;培氟哌酸
英文名称:Pefloxacin
CAS号:70458-92-3
分子式:C17H20FN3O3
分子量:333.36
类白色晶体，熔点270--272℃(分解)(从二甲基甲酰胺得到)。溶于碱性和酸性溶液，微溶于水。急性毒性LD50小鼠(mg/kg)：225静脉注射；1000口服；大鼠(g/kg)：1.5腹腔注射；2.5口服。
在氢氧化钠试液或冰醋酸中易溶。浅黄色结晶粉末。熔点251-255℃（分解）。易溶于冰醋酸，难溶于甲醇、丙酮、DMF，极难溶于水、乙醇、氯仿，不溶于苯，溶于稀碱或酸溶液。无臭，味苦。
溶解度1 M NaOH: soluble50mg/mL
CAS号:51940-44-4
分子式:C14H17N5O3
分子量:303.32
水溶解性Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water
双氟沙星/二氟沙星;双氟沙星;双氟哌酸
英文名称:Difloxacin
泼尼松龙
照高效液相色谱法（通知0512）测定。 内标溶液 取炔诺酮适量，加甲醇溶解并稀释制成每1mL中约含1.5mg的溶液。 供试品溶液 取本品适量，精密称定，加甲醇溶解并定量稀释制成每1mL中约含1mg的溶液，精密量取该溶液与内标溶液各 5mL，置50mL量瓶中，用甲醇稀释至刻度，摇匀。 对照品溶液 取泼尼松龙对照品适量，精密称定，加甲醇溶解并定量稀释制成每1mL中约含1mg的溶液，精密量取该溶液与 内标溶液各5mL，置50mL量瓶中，用甲醇稀释至刻度，摇匀。 色谱条件 用十八烷基硅烷键合硅胶为填充剂，以甲醇-水（65:35）为流动相，检测波长为240nm，进样体积10μL。 系统适用性要求
（5）使同位素脑和骨显像减弱或稀疏。
1、妊娠期用药：糖皮质激素可通过胎盘。动物实验研究证实孕期给药可增加胚胎腭裂，胎盘功能不全、自发 性流产和子宫内生长发育迟缓的发生率。人类使用药理剂量的糖皮质激素可增加胎盘功能不全、新生儿体重减少 或死胎的发生率。
2、哺乳期用药：由于糖皮质激素可由乳汁中排泄，对婴儿造成不良影响，如生长受抑制、肾上腺皮质功能抑 制等。
1、取本品10mg，加甲醇1mL解后，加碱性酒石酸铜试液1mL，加热，即生成橙红色沉淀。 2、取本品约2mg，加硫酸2mL，渐显深红色，无荧光，加水10mL，红色褪去，生成灰色絮状沉淀。 3、在含量测定项下记录的色谱图中，供试品溶液主峰的保留时间应与对照品溶液主峰的保留时间一致。 4、本品的红外光吸收图谱应与对照的图谱（光谱集284图）一致。
摩尔折射率：95.48 摩尔体积（cm3/mol）：274.7 等张比容（90.2K）：766.8 表面张力（dyne/cm）：60.7 极化率（10-24cm3）：37.85
疏水参数计算参考值（XlogP）：1.6 氢键供体数量：3 氢键受体数量：5 可旋转化学键数量：2 互变异构体数量：9 拓扑分子极性表面积（TPSA）：94.8 重原子数量：26 表面电荷：0 复杂度：724 同位素原子数量：0 确定原子立构中心数量：7
罗米司亭及艾曲波帕药品说明书
根据病人的病情选择：1.确定什么原因引起的血小板减少，至少要找到疾病的诱因。
免疫系统？骨髓造血系统？分泌（激素）？2.若不能找到诱因，一定要使用该两种药品，先用6周，看看效果，查血小板计数，是否继续使用，再做评估。
罗米司亭【商品名】Nplate【药品名称】罗米司亭/ romiplostim【适应症】治疗脾切除和脾未切除慢性免疫性血小板减少性紫癜（ITP）成人患者的血小板生成药。
【用法用量】（1）初始剂量1μg/kg每周1次皮下注射。
（2）因为需要减低出血的风险，通过增量1μg/kg调整每周剂量以达到和维持血小板计数50 × 109/L.（3）最大剂量不要超过每周10μg/kg。
如血小板计数达>400×109/L不要给药。
（4）如在最大剂量4周后血小板计数不增加中断Nplate。
（5）在配制期间不要震荡；避光保护配制好的Nplate； 24小时给配制好的Nplate。
（6）注射容积可能非常小。
使用刻度0.01 mL的注射器。
（7）遗弃单次使用小瓶中未使用部份。
【注意事项】（1）Nplate增加骨髓网硬蛋白(reticulin)沉积的风险；临床研究未除外网硬蛋白和其它纤维沉积导致有血细胞减少的骨髓纤维化的可能性。
监查外周血骨髓纤维化征象。
（2）中止Nplate可能导致血小板减少比Nplate治疗前更坏。
Nplate中止后监查全血细胞计数(CBCs)，包括血小板计数至少2周。
（3）过量Nplate可能增加血小板计数至产生血栓形成/栓塞并发症的水平。
（4）如随Nplate初期反应后血小板计数严重减低评估患者中和抗体的形成。
（5）Nplate可能增加血液学恶性病的风险，尤其是有骨髓增生异常综合征患者。
（6）每周监查CBCs，包括血小板计数和外周血涂片，直至达到稳定的Nplate 剂量。
其后，至少每月监查CBCs，包括血小板计数和外周血涂片。
（7）只能通过受限制的分配计划，称为Nplate NEXUS(了解和支持Nplate专家和患者网络)计划，才能获得Nplate。
水落坡药品基本信息
0.38 31.185 5.4 4.455 7.56 1.148 1.58 1.32 6.75 1.431 1.89 3.105 3.915 3.713 21.195 15.525 3.105 2.768 2.7 15.755 4.72 3.375 4.59 8.37 1.89 9.18 3.105 3.375 2.16 10.598 5.4 14.85 19.575 3.78 3.105 2.835 6.075 4.05 4.995 3.51 6.075 1.823 1.98 1.08 1.013 2.025 2.565
10支 1ml*10mg 0.25g*12t 20李*0.25g 0.25g*10粒 250mg*10粒 0.25g*10粒
0.25g*10s*2b
针剂 片剂 胶囊 胶囊 胶囊
颗粒 125mg*12代 0.6 0.6g-海口 0.6g 0.2285g6袋 20t 1g １ｇ 0.5g*12s 100片 6t*0.25g 0.1g*6 0.1g*4d 0.25g 0.1g*3包 0.25g*6t
粉剂
片剂 片剂 粉剂
针剂 粉剂 片剂
6粒* 0.25g*6 0.25G*10粒 0.1g*18d 0.1G*6D 0.1g*6包 粉剂 0.1g*6d 0.25g 25mg*6 0.25g*6t 250 0.25g 0.25g 25mg*100片 25mg 25mg*60t
片剂 片剂 针剂
片剂
g 盒 盒 盒 盒 板 板 板 盒 板 盒 合 支 支 支 盒 合 支 支 盒 瓶 盒 盒 盒 包 支 合 盒 盒 盒 盒 盒 盒 盒 盒 盒 盒 支 盒 合 瓶 支 支 瓶 瓶 瓶 瓶
3.78 3.78 3.78 1.215 1.62 1.62 1.02 1.208 1.17 0.81 1.2 0.945 1.971 1.08 0.878 2.16 0.9 0.945 0.975 2.1 1.013 1.92 2.025 1.89 4.32 2.16 2.295 26.865 8.64 2.12 4.32 1.688 1.89 2.4 2.805 2.43 1.188 8.033 2.295 10.125 6.75 7.425 2.538 1.418 5.13 607.5 297
拓扑替康结构式 -回复
拓扑替康结构式-回复拓扑替康（Tofacitinib）是一种属于JAK抑制剂的药物，用于治疗关节炎、银屑病和溃疡性结肠炎等自身免疫性疾病。
该药物的结构式如下所示：[拓扑替康结构式]拓扑替康属于一种小分子化合物，其化学名称为“3-{(3R，4R)-4-[(4-{(1E)-2-(5-氯-2-氧代苯基)乙-1-烯基}-1-苯基环己基)氨基]-3-甲基环己基}丙酸甲酯”。
它的化学式为C16H20N6O，分子量为312.37g/mol。
拓扑替康为无色结晶状固体，可溶于有机溶剂或水。
作用机制：拓扑替康通过抑制Janus激酶（JAK）的活性来发挥其治疗作用。
JAK是一类细胞内酪氨酸激酶，对细胞信号转导和调控起着重要作用。
通过抑制JAK的活性，拓扑替康可以干扰多个细胞因子途径的信号传递，从而调控免疫系统，减轻相关疾病的症状。
药物应用：拓扑替康已被美国食品药品监督管理局（FDA）批准用于治疗成人类风湿性关节炎、银屑病性关节炎、中度至重度溃疡性结肠炎以及活动性类风湿性关节炎。
它通常在其他治疗方法无效或无法耐受的情况下使用。
治疗效果：在临床试验中，拓扑替康已被证明能有效减少关节炎相关的关节疼痛、关节肿胀和关节运动受限等症状。
在银屑病和溃疡性结肠炎的治疗中，使用拓扑替康也能减少病情的恶化和复发。
注意事项：1. 在使用拓扑替康之前，患者应告知医生有关其过敏史、其他药物的使用情况以及存在的其他疾病，以便医生进行全面评估。
2. 拓扑替康可能会增加感染的风险。
在使用期间，患者应密切注意任何感染的症状，并及时向医生报告。
3. 服用拓扑替康可能导致一些不良反应，如头痛、腹泻、恶心、呕吐等。
如有不适，应立即告知医生。
总结：拓扑替康是一种抗关节炎和免疫性疾病药物，通过抑制JAK的活性，调控免疫系统，从而减轻相关疾病的症状。
尽管其可以有效改善患者的症状，但患者在使用该药物时需要密切关注可能产生的不良反应，并向医生报告任何异样症状。
通过科学的用药指导和临床监测，拓扑替康可以为患者提供更好的治疗效果。
盐酸拓扑替康
盐酸拓扑替康一、 基本信息【类 型】： 抗肿瘤药【剂 型】：粉针，胶囊【规 格】：粉针：0.2mg/瓶；胶囊：0.25mg/粒；【适 应 症】：经一线化疗失败小细胞肺癌。
晚期转移性卵巢癌。
【用法用量】：1．剂量：推荐剂量为1.2mg/m2/日，静脉输注30分钟。
持续5天，21天为一疗程，治疗中严重的中性粒细胞减少症患者，在其后的疗程中剂量减少0.2mg/m 2或与G-CSF同时使用。
使用从第6天开始，即在持续5天使用本品后24小时后再用G-CSF 。
2．注射液配制：用无菌注射用水1ml 溶解本品1mg 比例溶解本品，按1.2mg/m 2二、 国内注册情况（截止2009.9.14）/日剂量抽取药液，用0.9％氯化钠或5％葡萄糖注射液稀释后静脉输注。
【原 研 厂】： 英国史克-比彻姆（Smith Kline Beecham ）公司研制开发【国外上市】：在美国，欧洲等30多个国家上市【注册分类】：6类【制剂工艺】： 制备工艺可行性高，不需要特殊生产设备；在中国上市和注册情况列表A．已上市国产原料6家，制剂6家（胶囊1家，粉针：6家）1.盐酸拓扑替康(国药准字H20052425 黄石飞云制药有限公司)2.盐酸拓扑替康(国药准字H20000435 扬州奥赛康药业有限公司)3.盐酸拓扑替康(国药准字H20000427 贵州汉方制药有限公司)4.盐酸拓扑替康(国药准字H20000433 扬子江药业集团有限公司)5.盐酸拓扑替康(国药准字H20000437 江苏恒瑞医药股份有限公司)6.盐酸拓扑替康(国药准字H20000439 重庆润康药业有限公司)制剂1.盐酸拓扑替康胶囊(国药准字H20070203南京瑞年百思特制药有限公司)2.注射用盐酸拓扑替康(国药准字H20060891 江苏奥赛康药业有限公司3.注射用盐酸托泊替康(国药准字H20052432 黄石飞云制药有限公司)4.注射用盐酸拓扑替康(国药准字H20000429 贵州汉方制药有限公司)5.注射用盐酸拓扑替康(国药准字H20000434 扬子江药业集团有限公司)6.注射用盐酸拓扑替康(国药准字H20000438 江苏恒瑞医药有限公司)进口1家1.注射用盐酸托泊替康(H20080385 SmithKline Beecham)B．正在申报盐酸拓扑替康 CYHS0900251川四川科瑞德凯华制药有限公司三、立题分析【英文名】：Topotecan Hydrochloride【化学名】：【分子式】：C23H23N3O5.HCl【分子量】：457.91【CAS号码】：123948-87-8【结构式】：盐酸拓扑替康是英国史克-比彻姆（SmithKline Beecham）公司研制开发的水溶性喜树碱衍生物。
Expression, Purification and Crystallization of
Expression, Purification and Crystallization of the Mycobacterium Tuberculosis HSP16.3 Molecular Chaperone Background of Mycobacterium Tuberculosis HSP16.3HSP16.3, a 16.3 kDa protein from Mycobacterium Tuberculosis, was originally identified as a prominent antigen (Kingston et al., 1987). During the stationary phase, HSP16.3 is maximally expressed and becomes a main protein of the latent phase (Yuan et al., 1996). Previous studies showed that HSP16.3 can make the cell structure stable and prevent stationary Mycobacterium Tuberculosis from autolysing (Cunningham et al., 1998). In previous studies, HSP16.3 was found as one of theα-crystallin-related small heat shock proteins (sHSP) with molecular chaperone activity. Experiments in vitro revealed that HSP16.3 can suppress the thermal aggregation of citrate synthase at 39.5˚C, without consumption of A TP (Chang et al., 1996).Now the Mycobacterium Tuberculosis HSP16.3 gene was cloned to the plasmid pSTE-HSP16.3, and transformed to E.Coli. BL21(DE3) strain.Material and MethodExpressionThings to have ready before Starting.-Plate or glycerol culture-Sterile LB 25ml in a 50mL shaker flasker, 250ml in a 500mL shaker flasker, all together autoclaved, antibiotic added afterword.- antibiotic and sterile water- TipsPrepare the LB and autoclave:Fomula of the LB medium for 1 Liter:Bacto Tryptone (BT) 10 gBacto Y east Extract (BYE) 10 gNaCl 10gThe LB medium, dd H2O and the tips all together autoclaved at 121 ˚C for 20 minutes.Method:1 Innoculate 25 ml LB Medium ( containing 100 ug) and grow culture overnight(37˚C, 200rpm).2 Next morning inoculate 250 ml prewarmed LB Medium ( containing 100 ug) with the 25 ml overnight culture and grow at 37 ˚C, 200rpm, HSP16.3 was overexpressed in soluble form intracellularly without IPTG induction.3 Incubate the Culture for 10 hours before havesting the cell at 4000 g for 20 minutes.4 Resuspend the cell pellet in 30 ml Butter A and freeze the Sample in -80˚C refigerator.PurificationDE52 Ion-Exchange columnThings to have ready before Starting.-Butter A: 50 mM Imidazole pH 6.5 (1 liter)-Butter B: 50 mM Imidazole pH 6.5 , 300mM NaClall together Fitrate with 0.2 um membrane.- DE52 medium , column ,Gradient maker, UV-monitor and Fractioner- TipsMethod:1 Thaw the cell pellet and vortex .2 Add 0.4ml 100 mM PMSF and sonicate (400kw, 4s-6s 50 cycle* 5 )3 Centrifuge 15000 rpm, 30 minutes to pellet debris4 Transfer supernatant to a 50 ml conicale tube and discard the pellet.5 The supernatant dilute to 50 ml with Buffer A and then load to DE52 ion-exchange columns (20ml), which was pre-equibrated with 100ml Buffer A. And then wash the unbound proteins with 100 ml Buffer A.6 Elute the protein with a linear gradient : 200ml buffer A plus 200ml buffer B, 2ml/min, 6ml each fraction.7 Run 15% SDS-PAGE to determine the HSP16.3 peak.Desalting by dialysis1 Preparation of the dialysis tubeCut the tube in a suitable length (20-30 cm)Boil the tube in solution containing 10 mM NaHCO3 for a few minutes.Boil the tube in solution containing 10 mM EDTA for a few minutes.Rasin the tube with de-ion water2 Pool the HSP16.3 peak and dialysis the Sample against 1000ml Buffer A for more than 6hours.Q-Separose (HP) Ion-Exchange Column1 load the sample to Q-Separose (HP) Ion-Exchange column (20ml), which was pre-equibrated with 100ml Buffer A. And then wash the unbound proteins with 100 ml Buffer A.2 Elute the protein with a linear gradient : 200ml buffer A plus 200ml buffer B, 2ml/min, 6ml each fraction.3 Run 15% SDS-PAGE to determine the purity of the HSP16.3 peak.Gel filtration ColumnThe HSP peak was a final volumn 0.3ml and then run though a Superdex75 (HR, 10/30mm) gel filtration column in 150mM NaCl and 5mM Imdazole, pH6.5. Crystallization1 The purified HSP16.3 was solvent-exchanged to water and concentrated to 20mg/ml before crystallization trails (Bradford). All the crystallization trials were carried out using the hanging-drop vapor-diffusion method at 291K: drops consisted of2 microlitres of HSP16.3 protein solution plus 2 microlitres of the precipitant. The drops were equilibrated against 0.2 ml precipitant at room temperature. The crystallization conditions were investigated with a PEG4000 Kit.Result and discussionThe purity of the final HSP16.3 was over 95% by SDS-PAGE. The crystallization trials of HSP16.3 yielded Cubic crystals with a size of 0.8*0.8*0.6mm in a few days.20040060080010001200mAUBuffer Tris-HCL pH 8.5 Precipitant PEG 4000 MethodV apor Diffusion Temperature 293 K Size0.8*0.8*0.6mmReferencesChang Z., Primm, T.P., Jakana J., Lee H. I., Serysheva I., Chiu W., Gilber H. F., Quiocho F. A., (1996) J Biol Chem 271:7218-7223Cunningham A. F., Spreadbury C. L., (1998) J. Bacteriol. 184:801-808Kingston A. E., Salgame P. R., Mitchison N.A., Colston M. J. (1987) Infect. Immun 55,3149-3154Yuan Y., Crane D. D., Barry C. E. III (1996) J Bacteriol178: 4484-4492。
【药品名】阿洛司琼【英文名】ALOSETRON【别名】盐酸阿洛
【药品名】阿洛司琼【英文名】Alosetron【别名】盐酸阿洛司琼；洛曲尼斯；罗肠兴；Alosetron Hydro-chloride；Lotronex【剂型】阿洛司琼片剂：0.5mg/片(含盐酸阿洛司琼0.562mg)，1mg/片(含盐酸阿洛司琼1.124mg)。
室温，防潮，避光保存。
【药理作用】本品为5-羟色胺(5-HT)受体拮抗剂，可抑制非选择性阳离子通道的活化，进而调节肠神经系统，抑制胃肠道神经元上的5-HT受体的活化，减少肠道分泌、蠕动和传入疼痛信号。
【药动学】本品口服吸收快，生物利用度50%～60%，年轻男性志愿者口服本品1mg后，最大血药浓度(C)约为5ng/ml，达峰时间(T)约为1h，年轻女性C约为9ng/ml，T约为1h。
男性志愿者连服本品28天(2mg，1天2次)，第28天C为12.4ng/ml，T为1.7h，首日和第28天的药时曲线下面积(AUC)分别为26.6ng·h/ml和39.4ng·h/ml。
与食物同服，本品吸收率降低25%，达峰时间延后15min。
本品表观分布容积为65～95L，血浆蛋白结合率为82%，每天2次给药无蓄积。
本品经肝脏CYP2C9、CYP3A4、CYP1A2被广泛代谢，其代谢产物的C为原药的9倍，AUC为13倍，半衰期为2倍，显示存在循环代谢产物。
本品主要通过肾脏清除，肾脏清除率为94ml/min。
约73%剂量从尿中回收，24%从粪便回收，仅7%为原药。
【适应症】本品适用于女性以腹泻为主的严重肠易激综合征(irritability bowel symptom，IBS)，包括病程超过6个月或胃肠道解剖生化异常或普通治疗无效的严重IBS，可减轻下腹部疼痛、腹部不适、尿急、腹泻症状。
【禁忌症】1.对本品过敏者禁用。
2.便秘患者、有严重便秘史或便秘后遗症者禁用。
3.肠梗阻、肠狭窄、中毒性巨结肠、胃肠穿孔、胃肠粘连、缺血性结肠炎、局限性肠炎(克隆病)、活动性溃疡性结肠炎、有活动性憩室炎或病史患者禁用。
盐酸可乐定 中英文药典对照
美国药典：Clonidine HydrochlorideC9H9Cl2N3·HCl 266.55Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-, monohydrochloride.2-[(2,6-Dichlorophenyl)imino]imidazolidine monohydrochloride [4205-91-8].» Clonidine Hydrochloride contains not less than 98.5 percent and not more than 101.0 percent of C9H9Cl2N3·HCl, calculated on the dried basis.Packaging and storage—Preserve in tight containers. Store at 25, excursions permitted between 15and 30.USP Reference standards 11—USP Clonidine Hydrochloride RS.Identification—A: Infrared Absorption 197K.B: Ultraviolet Absorption 197U—Solution: 330 µg per mL.Medium: 0.01 N hydrochloric acid.Absorptivities at 272 nm, calculated on the dried basis, do not differ by more than 3.0%.C: It responds to the tests for Chloride 191.pH 791: between 3.5 and 5.5, in a solution (1 in 20).Loss on drying 731— Dry it at 105to constant weight: it loses not more than 0.5% of its weight.Residue on ignition 281: not more than 0.1%.Chromatographic purity— Dissolve 200 mg in methanol, and dilute with methanol to 2.0 mL to obtain the test solution. Dissolve a suitable quantity of USP Clonidine Hydrochloride RS in methanol to obtain a Standard solution having a known concentration of 100 mg per mL. Dilute a portion of this solution quantitatively and stepwise with methanol to obtain a diluted Standard solution having a concentration of 100 µg per mL. Apply separate 2-µL portions of the test solution, the Standard solution, and the diluted Standard solution to asuitable thin-layer chromatographic plate (see Chromatography 621) coated with a 0.25-mm layer of chromatographic silica gel mixture. Develop the chromatogram in a freshly prepared solvent system consisting of a mixture of toluene, dioxane, dehydrated alcohol, and ammonium hydroxide (10:8:2:1), until the solvent front has moved three-fourths of the length of the plate. Remove the plate from the chamber, allow the solvent to evaporate, and dry it at 100for 1 hour. Dip the plate into a dipping chamber filled to three-fourths of its height with sodium hypochlorite solution, diluted to contain 0.5% available chlorine, dry in a fume hood with a current of air for 1 hour, and spray with starch-potassium iodide TS: the R F value of the principal spot from the test solution corresponds to that of the Standard solution. Any other spot obtained from the test solution does not exceed, in size or intensity, the principal spot obtained from the diluted Standard solution (0.1%), and the total of any spots does not exceed 0.2%.Assay— Dissolve about 200 mg of Clonidine Hydrochloride, accurately weighed, in about 80 mL of glacial acetic acid, add 15 mL of mercuric acetate TS, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically, using a glass electrode and a sleeve-type calomel electrode containing 0.1 N lithium perchlorate in glacial aceticacid (see Titrimetry 541). Perform a blank determination, and make any necessarycorrection. Each mL of 0.1 N perchloric acid is equivalent to 26.66 mg of C9H9Cl2N3·HCl. Auxiliary Information—Please check for your question in the FAQs beforecontacting USP.USP32–NF27Page 1988Pharmacopeial Forum : Volume No. 29(5) Page 1440翻译：盐酸可乐定C 9H 9Cl 2N 3·HCl 266.55苯胺、N 2 -氯- 2 -咪唑叉，盐酸盐[（2 2 -苯基）氨基]咪唑烷盐酸盐[ 4205 91 8 ]盐酸可乐定包含不小于百分之98.5并且不大于c9h9cl2n3•盐酸百分之101，在干燥的基础上计算。
欧洲药典7.5版
INDEX
To aid users the index includes a reference to the supplement in which the latest version of a text can be found. For example : Amikacin sulfate...............................................7.5-4579 means the monograph Amikacin sulfate can be found on page 4579 of Supplement 7.5. Note that where no reference to a supplement is made, the text can be found in the principal volume.
English index ........................................................................ 4707
Latin index ................................................................................. 4739
EUROPEAN PHARMACOPபைடு நூலகம்EIA 7.5
Index
Numerics 1. General notices ................................................................... 7.5-4453 2.1.1. Droppers...................
酒石酸阿福特罗
32009 Vol.30 No.死亡、非致死性心脏病发作和脑卒中的疗效较氯吡格雷提高19%，但导致严重出血的风险也上升了32%。
药品安全性报道FDA 警告磷酸铬混悬液不宜关节内注射美国FDA 发布Mallinckrodt 公司告医务人员信，警告与磷酸铬混悬液相关的白血病风险。
磷酸铬混悬液获准用于腔内（腹腔和胸腔）注射给药，治疗因转移性肿瘤引起的腹膜或胸腔积液。
2例血友病儿童患者在接受了本品关节内注射后一年内出现了急性淋巴细胞性白血病。
FDA 未批准本品用于关节内注射。
鉴于此，Mallinckrodt 公司对本品说明书进行了修订。
在“警告”部分增加有关白血病的内容：磷酸铬混悬液在一定情况下会增加发生白血病的风险。
2例（9和14岁）血友病患者在接受关节内注射本品（注射总剂量分别为0.6和1.5 mci ）后约10月发生急性淋巴细胞性白血病。
本品不适用于关节内注射治疗关节出血。
在“不良反应”部分增加提醒：儿童患者可出现白血病；腹膜腔内给药对小肠、盲肠和膀胱可能造成放射性损伤（坏死和纤维化）。
肝损伤患者慎用厄洛替尼最近，美国FDA 发布OSI 制药公司和基因技术公司告知医务人员信，警告肝损伤患者使用厄洛替尼（erlotinib ，Tarceva ）应密切接受肝功能监测，必要时应中断或停止用药。
厄洛替尼单药治疗适用于至少接受过1次化疗失败的局部晚期或转移性非小细胞肺癌患者。
本品与吉西他滨联用适用于局部晚期、不可切除或转移性胰腺癌患者的一线治疗。
新的安全信息来自于对实体瘤晚期和按照Child-Pugh 分级为中度肝损伤患者进行的药动学研究。
在接受研究的15例患者中，有10例在接受本品治疗期间或最后1次用药的30天内死亡。
尽管有8例死于疾病的发展，但仍有1例死于肝肾综合征及1例死于快速进行性肝功能衰竭。
10例患者中有6例死亡时的总胆红素高于3 ULN ，说明出现了重度肝损伤，从而突出了在肿瘤患者人群中使用本品的Child-Pugh 分级限制。
硝酸铊
硝酸铊白色结晶。
溶于水，溶于丙酮，不溶于乙醇。
热至450℃分解，75℃时γ型转化为β型，145℃时β型转化为α型；与易燃物摩擦或撞击易爆炸。
用作分析试剂及光导纤维。
由金属铊粉末与稀硝酸进行反应制得。
目录1简介2物理性质3化学性质4制备5应用6注意事项1简介中文同义词：硝酸亚铊(1+)；硝酸亚铊；硝酸铊(I)；硝酸铊(III)；硝酸亚铊(I)；硝酸铊(I), PURATRONIC|R, 99.9995% (METALS BASIS)；[1]英文同义词：Nitric acid, thallium(1+)salt;Nitricacid,thallium(1+)salt;nitricacid,thallium(1++)salt;Rcra waste number U217;rcrawastenumberu217;Thallium mononitrate;Thallium nitrate (Tl(NO3));Thallium(I) nitrate (1:1)；EINECS号：233-273-1；[1]Mol文件：10102-45-1.mol。
[1]2物理性质CAS No.： 10102-45-1[2]外观与性状：白色结晶。
熔点(℃)：206（α型）相对密度（水=1）：5.55沸点(℃)：450（分解）溶解性：溶于水，溶于丙酮，不溶于乙醇。
[3]不同温度(℃)时每100毫升水中的溶解克数：3.9g/0℃；6.22g/10℃；9.55g/20℃；14.3g/30℃；21g/40℃；46.1g/60℃；110g/80℃；200g/90℃；414g/100℃。
[1]3化学性质热至450℃分解，75℃时γ型转化为β型，145℃时β型转化为α型。
[4]与还原剂、有机物、易燃物如硫、磷或金属粉末等混合可形成爆炸性混合物。
经摩擦、震动或撞击可引起燃烧或爆炸。
[3]毒理学数据：急性毒性主要的刺激性影响：在皮肤上面：刺激皮肤和黏膜；在眼睛上面：刺激的影响；致敏作用：没有已知的敏化影响。