NANOPARTICLE FORMATION VIA RAPID PRECIPITATION
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专利名称：NANOPARTICLE FORMATION VIA RAPID
PRECIPITATION
发明人：Hsien-Hsin Tung,Lei Wang,Santipharp
Panmai,Michael Riebe
申请号：US12989148
申请日：20090420
公开号：US20110053927A1
公开日：
20110303
专利内容由知识产权出版社提供
专利附图：
摘要：The invention encompasses a method for making nano-sized particles of water-insoluble pharmaceuticals comprising: (1) dissolving the water-insoluble pharmaceutical
in a water-miscible solvent, optionally with water and inactive pharmaceutical ingredients, to make a solution; (2) rapidly mixing the solution with an anti-solvent which creates a high level of supersaturation, wherein the anti-solvent is water with optional inactive pharmaceutical ingredients; (3) simultaneously applying energy to the resulting mixture during the mixing of solution and anti-solvent as nano-sized drug particles precipitate out and form a slurry mixture under supersaturation; and (4) optionally isolating the nano-sized particles of water-insoluble pharmaceuticals from the slurry mixture.
申请人：Hsien-Hsin Tung,Lei Wang,Santipharp Panmai,Michael Riebe
地址：Edison NJ US,Ambler PA US,North Wales PA US,Collegeville PA US
国籍：US,US,US,US
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