急性脑梗死患者糖化血红蛋白、C反应蛋白以及血清和肽素变化及临床意义

急性脑梗死患者糖化血红蛋白、C反应蛋白以及血清和肽素变
化及临床意义
陈林芳;田向阳;孙波;赵卫东
【期刊名称】《脑与神经疾病杂志》
【年(卷),期】2017(025)005
【摘要】目的研究血清和肽素(CPP)、糖化血红蛋白(HbA1c)及C反应蛋白(CRP)与急性脑梗死(ACI)之间的相关性及临床意义.方法选取2015年1月至2016年3月本院ACI患者80例,同时选取在年龄、性别等基本资料相匹配的80例健康者作为对照组,收集ACI患者住院3d和14d以及健康志愿者血清CPP、CRP以及HbA1c水平变化趋势,分析对比血清CPP、CRP以及HbA1c水平与ACI患者之间的相关性及临床意义.结果入院后3d及14d ACI患者与健康对照组CPP、CRP和HbA1c水平对比,结果提示ACI重度组CPP、CRP和HbA1c水平最高,其次是中度和轻度组,均P＜0.01.NIHSS评分与CPP、CRP和HbA1c水平相关性分析,结果提示NIHSS评分分别与CPP呈正相关性(r=0.78,P＜0.01)、与CRP呈正相关性(r=0.82,P＜0.01)、与HbA1c呈正相关性(r=-0.59,P＜0.05);非条件Logistic回归分析提示CRP、CPP以及HbA1c均是影响ACI病情的危险因素,且OR值均高于5,(P＜0.01).结论血清CPP、CRP和HbA1c水平变化趋势能够预测ACI患者病情发展,并且作为早期ACI诊治指标具有重要临床意义.%Objective To study and the relationship between clinical significance of the serum and peptide hormones (CPP),glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP) in acute cerebral infarction (ACI).Method Selected January 2015 to March 2016,eighty patients with ACI,and the same time selected the basic
information such as age,gender,matching the eighty cases of healthy subjects as control group,collected all the cerebral infarction patients and healthy volunteers.Results Compared in hospital for three days and fourteen day back infarction patients compared with healthy controls CPP,CRP and HbA1c level.Severe cerebral infarction group of CPP,CRP and HbA1c level the highest,followed by moderate and mild group,after statistics analysis,P＜0.01,there is significantly statistical differences.NIHSS score with CPP,CRP and HbA1c level correlation analysis,the results suggest NIHSS score was positively correlation with CPP (r=-0.78,P＜
0.01);Positive correlation between CRP and (r=0.82,P＜0.01);With HbA1c was positively correlation (r=0.59,P＜0.05);Unconditioned Logistic regression analysis suggest CRP,CPP and HbA1c is affects the risk factors of cerebral infarction disease,and the OR values were higher than five,after statistics analysis,P＜0.01,with statistical significance.Conclusion CPP,serum CRP and HbA1c level trends to predict progression of ACI patients,and as indicators of early diagnosis and treatment of cerebral infarction has important clinical significance.
【总页数】3页(P287-289)
【作者】陈林芳;田向阳;孙波;赵卫东
【作者单位】223300江苏,南京医科大学附属淮安第一医院神经内科;223300江苏,南京医科大学附属淮安第一医院神经内科;223300江苏,南京医科大学附属淮安第一医院神经内科;223300江苏,南京医科大学附属淮安第一医院神经内科
【正文语种】中文
【中图分类】R743.34
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