马来酸依那普利叶酸片对H型高血压降同型半胱氨酸的疗效及安全性

马来酸依那普利叶酸片对H型高血压降同型半胱氨酸的疗效
及安全性
雷蔚;莫新玲;李林健
【期刊名称】《医学综述》
【年(卷),期】2015(000)008
【摘要】Objective To evaluate efficacy and safety of enalapril-folate acid tablets in lowering plasma homocysteine(Hcy).Methods From May 2011 to Aug.2013,a total of 107 H-type hypertensive patients in the Affiliated Hospital of Guilin Medical University were enrolled .The patients were randomly divided into three groups: enalapril ( 10 mg/d )-folate ( 0 .8
mg/d ) acid therapy as group A ( 40 cases );amlodipine (5 mg/d) and folateacid(0.8 mg/d) therapy as group B (33 cases).Irbesartan(150 mg/d) and folate acid(0.8 mg/d)therapy was considered as group C (34 cases).All patients were monitored for the change of their plasma Hcy over a period of eight weeks.Results The results indicated the plasma Hcy of all patients from three groups in the fouth and eighth week were significantly reduced compared with baseline values.The level of Hcy of patients from group A and group C in the eighth week was lower than in the fouth week (all P
<0.05).Efficacy of Hcy of patients from group A was better than group B and group C. Conclusion Enalapril-folate acid tablets that can be used to reduce plasma Hcy level of H-type hyperten-sive patients safely and effectively is better than amlodipine or irbesartan combined with folate
acid .%目的：评价马来酸依那普利叶酸片用于H型高血压患者降同型半胱氨酸（ Hcy）的疗效和安全性。

方法选择2011年5月至2013年8月桂林医学院附属医院收治的 H 型高血压患者107例，采用随机数字表法分为A、B、C三组，A
组40例，B组33例，C组34例。

A组：马来酸依那普利（10 mg／d），＋叶酸固定复方制剂（0.8 mg／d）；B组：氨氯地平（5 mg／d）＋叶酸（0.8 mg
／d）；C 组：厄贝沙坦（150 mg／d）＋叶酸（0.8 mg／d），三组患者均为口服用药，连续治疗8周。

观察三组患者Hcy的变化。

结果三组患者在治疗第4周、第8周 Hcy均较同组自身基线值降低，同组第8周的Hcy均较第4周Hcy降低（均P＜0.05），但A组比B组、C组降Hcy效果好。

结论马来酸依那普利叶酸
片对于降低H型高血压患者近期的Hcy的效果优于氨氯地平或厄贝沙坦联合叶酸的效果。

【总页数】2页(P1489-1490)
【作者】雷蔚;莫新玲;李林健
【作者单位】徐州市肿瘤医院心血管内科，江苏徐州221005;桂林医学院附属医
院心血管内科，广西桂林541001;桂林医学院附属医院心血管内科，广西桂林541001
【正文语种】中文
【中图分类】R544.1
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