甲状腺髓样癌遗传学研究进展

甲状腺髓样癌遗传学研究进展
徐洪波;虢毅;邓昊
【期刊名称】《生命科学研究》
【年(卷),期】2012(16)1
【摘要】甲状腺髓样癌(medullary thyroid carcinoma,MTC)是起源于甲状腺C 细胞或滤泡旁细胞的恶性肿瘤,分遗传型髓样癌和散发型髓样癌两种.MTC主要由RET原癌基因突变引起,对患者进行基因测序分析能在基因水平诊断MTC,从而为患者早期行预防性手术治疗提供依据.从甲状腺髓样癌临床分型、分子遗传基础及动物模型不同层面进行综述,有利于进一步了解疾病致病机制和开展药物实验性治疗研究.%Medullary thyroid carcinoma (MTC) is a malignancy that originates from parafollicular C cells of the thyroid gland, which is divided into two types, including hereditary and sporadic forms. MTC is mainly caused by germline mutations in the RET proto-oncogene. The direct gene sequencing analysis for patients can diagnose MTC at gene level, thereby providing the basis for early preventive surgery treatment. Different angles including the clinical types, basic of molecular genetics and animal models of medullary thyroid carcinoma are reviewed, which will contribute to further understanding the pathogenic mechanism and would help to carry out drug experimental treatments of this disease.
【总页数】6页(P74-78,84)
【作者】徐洪波;虢毅;邓昊
【作者单位】中南大学湘雅三医院医学实验中心,中国湖南长沙410013;中南大学湘雅医学院生理系,中国湖南长沙410078;中南大学湘雅三医院医学实验中心,中国湖南长沙410013
【正文语种】中文
【中图分类】Q754
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