蒙古族人群血管紧张素转换酶基因多态性与高血压的关系

蒙古族人群血管紧张素转换酶基因多态性与高血压的关系刘丽娟;叶宏;佟伟军;冯华;黄桂蓉;李永山;巴图;张永红
【期刊名称】《中国组织工程研究》
【年(卷),期】2004(008)030
【摘要】BACKGROUND: Studies on the relationship between angiotensin-converting enzyme(ACE) and hypertension is well documented, but so far the relationship remains poorly understood in Mongolian population, a minority group at greater risk for hypertension.OBJECTIVE: To explore the association between ACE gene polymorphism and hypertension in Mongolian population.DESIGN: A cross-sectional study was conducted.SETTING and PARTICIPANTS: This study was conducted in the inhabitants who lived in Kezuohouqi in Tongliao City, Inner Mongolia of China. Fifty-one hypertensives and 32 normotensives, both positive for a family history of hypertension, along with another 64 hypertensives and 85 normotensives without family history of hypertension, were enrolled in this study.INTERVENTIONS: Polymerase chain reaction technique was used to detect the insertion/deletion(I/D) polymorphism of ACE gene.MAIN OUTCOME MEASURES: The frequency of ACE I/D polymorphism genotypes and allele was compared.RESULTS: There was no significant difference in the frequency of ACE genotypes(Ⅱ, ID, DD) among these 4 groups(P＞0.1). The frequency of ID genotype was the highest, followed by II genotype and then by DD genotype. The frequencies of I and D alleles were not
significantly different among these 4 groups(P＞0.01), but the frequency of I allele appeared higher.CONCLUSION: The I/D polymorphism of ACE gene is not related to hypertension in Mongolian population.%背景:有关血管紧张素转换酶基因多态性与高血压关系的研究已有报道,但在蒙古族人群中尚不十分清楚.蒙古族是高血压患病率较高的民族,因此有必要探讨蒙古族人群中血管紧张素转换酶基因多态性与高血压的关系.目的:探讨蒙古族人群血管紧张素转换酶基因多态性与高血压的关系.设计:采用现况调查的方法.地点和对象:选择内蒙古自治区通辽市科左后旗朝鲁吐苏木作为本研究现场,所有研究对象均为在此长期居住的蒙古族居民.共获得有高血压家族史的高血压者51例、血压正常者32例和没有高血压家族史的高血压者64例、血压正常者85例.干预:应用聚合酶链式反应检测血管紧张素转换酶基因的插入/缺失多态性.主要观察指标:血管紧张素转换酶多态性基因型频率和I、D等位基因频率.结果:血管紧张素转换酶基因的三种基因型(II,ID,DD)在4组人群间的分布差异无显著性意义(P＞0.1).在4组人群中均表现出ID基因型频率最高,其次为Ⅱ基因型,DD基因型频率最低.I,D等位基因在4组人群间的分布也差异无显著性意义(P＞0.1).在4组人群中I等位基因频率均高于D等位基因频率.结论:血管紧张素转换酶基因I/D多态性与蒙古族高血压的发生无关联.
【总页数】2页(P6764-6765)
【作者】刘丽娟;叶宏;佟伟军;冯华;黄桂蓉;李永山;巴图;张永红
【作者单位】哈尔滨医科大学公共卫生学院流行病教研室,黑龙江省,哈尔滨
市,150001;哈尔滨医科大学公共卫生学院流行病教研室,黑龙江省,哈尔滨
市,150001;苏州大学放射医学与公共卫生学院流行病教研室,江苏省,苏州
市,215007;内蒙古科左后旗卫生防疫站流行病科,内蒙古自治区,科左后旗,028000;哈尔滨医科大学公共卫生学院流行病教研室,黑龙江省,哈尔滨市,150001;内蒙古科
左后旗卫生防疫站流行病科,内蒙古自治区,科左后旗,028000;内蒙古通辽市卫生防疫站,内蒙古自治区通辽市,028000;苏州大学放射医学与公共卫生学院流行病教研室,江苏省,苏州市,215007
【正文语种】中文
【中图分类】R544.1
【相关文献】
1.血管紧张素转换酶基因I/D多态性及醛固酮合成酶基因T-344C多态性与蒙古族人群原发性高血压的相关性研究 [J], 呼日勒;张春雨;赵世刚;牛广明;李宏芬;胡日乐;王智光;江名芳
2.血管紧张素转换酶基因插入缺失多态性与中国部分非汉族人群原发性高血压关系的Meta分析 [J], 林晖;柳华;赵明才
3.蒙古族高血压者血管紧张素转换酶基因多态性与胰岛素抵抗及血脂的关系 [J], 刘丽娟;叶宏;佟伟军;刘国玉;李永山;黄桂蓉;王健;张永红
4.血管紧张素转换酶基因插入/缺失多态性与维吾尔族人群高血压病的关系 [J], 王芬;王束玫;吕明;王笑峰;金力;汪师贞;王俊杰
5.我国汉族人群血管紧张素转换酶基因多态性与原发性高血压关系的Meta分析[J], 姜玉;宋伟民
因版权原因，仅展示原文概要，查看原文内容请购买。