A METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUA
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专利名称：A METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUAL WITH INFECTION
发明人：RYAN, Thomas,WHITE, Mary,MCMANUS, Owen Ross,KELLEHER, Dermot
申请号：EP09756855.4
申请日：20091009
公开号：EP2334824A2
公开日：
20110622
专利内容由知识产权出版社提供
摘要：A method of estimating sepsis risk in an individual with infection comprises a step of assaying a biological sample from the individual for an IL-2 or IL-7 mRNA value, and correlating the mRNA value with sepsis risk. The IL-2 and IL-7 mRNA values are quantified by absolute quantification of mRNA copy number, wherein the copy numbers are normalised to a house keeping gene and corrected against a calibration curve for serial dilutions of the IL-2 and IL-7 cDNA. The method generally involves a step of assaying a biological sample from the individual for IL-2 and/or IL-7 mRNA values, optionally in combination with mRNA values for other cytokines, and correlating a sum or difference of the values with sepsis risk using a regression analysis curve against outcome.
申请人：The Provost Fellows And Scholars Of The College Of Queen Elizabeth Near Dublin
地址：College Green Dublin 2 IE
国籍：IE
代理机构：Purdy, Hugh Barry 更多信息请下载全文后查看。