NOVEL METHOD FOR ISOLATING ENDOTOXINS
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专利名称：NOVEL METHOD FOR ISOLATING ENDOTOXINS
发明人：CAROFF, MARTINE
申请号：EP03815086.8
申请日：20031208
公开号：EP1578442A1
公开日：
20050928
专利内容由知识产权出版社提供
摘要：Isolating endotoxins (I) from bacteria or culture supernatants comprising suspending the starting material in a mixture of solvents; separating suspended particles from the solution and removing solvent from the supernatant or filtrate, is new. Isolating endotoxins (I) from bacteria or culture supernatants comprises suspending the starting material in a mixture of solvents; separating suspended particles from the solution and removing solvent from the supernatant or filtrate. (A) comprises 30-70% 3-6C linear or branched aliphatic acid (II) and 70-30% basic aqueous solution of 0-12C aliphatic amine (III), and the mixture of starting materials and (A) is stirred to keep particles in suspension. Separation is by filtration, centrifugation and recovery of the supernatant, or by centrifugation and then filtration of the supernatant. An Independent claim is also included for a method for preparing a composition containing at least one (I), or its derivatives, for administration to humans or animals, that includes the new method for isolating (I).
申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DE PARIS 11-PARIS SUD
地址：3, rue Michel-Ange 75008 Paris FR,Le Moulin, 15 rue Georges Clémenceau 91405
Orsay FR
国籍：FR,FR
代理机构：Corizzi, Valérie
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