益寿丸对衰老模型小鼠学习记忆的影响

益寿丸对衰老模型小鼠学习记忆的影响
吴立蓉;黄张杰;黄兆胜
【期刊名称】《广东药学院学报》
【年(卷),期】2013(029)001
【摘要】Objective To study the effect and mechanism of YiShouWan (YSW) on learning and memory of D-galactose (D-gal)-induced aging mice. Methods D-galactose was used to establish the aging model in mice. Behavior experiment was measured by using step down and passive avoidance test. AchE activity, NO content and NOS activity were detected for observing the learning and memory of aging mice. Results YSW significantly improved the ability of learning and memory in aging mice, along with reducing AchE activity, NOS activity and NO content in brain tissues. Conclusion YSW can enhance the ability of learning and memory in aging mice, and its effect may be related to protection of the cholinergic nervous system and regulation of brain NO/NOS levels.%目的研究益寿丸对D-半乳糖(D-gal)所致衰老小鼠学习记忆的影响,探讨其抗衰老的作用机制.方法采用D-半乳糖复制亚急性衰老小鼠模型.采用跳台实验和避暗实验进行行为学测定；以乙酰胆碱酯酶(AchE)活性、氧化亚氮(NO)含量和氧化亚氮合酶(NOS)活性为指标,观察其对衰老小鼠学习记忆的影响.结果益寿丸能提高衰老小鼠的学习记忆成绩,明显降低衰老小鼠脑组织中AchE及NOS活性,降低NO含量.结论益寿丸能显著改善D-半乳糖致衰老小鼠学习记忆障碍,其作用机制可能与保护胆碱能神经系统并调节大脑NO/NOS水平有关.
【总页数】4页(P60-63)
【作者】吴立蓉;黄张杰;黄兆胜
【作者单位】广州中医药大学中药学院,广东广州510006
【正文语种】中文
【中图分类】R285
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