Non-human transgenic animals for the study of neur

专利名称：Non-human transgenic animals for the study
of neurodegenerative syndromes
发明人：Antonino Cattaneo,Simona
Capsoni,Francesca Ruberti
申请号：US10049306
申请日：20000728
公开号：US07273964B1
公开日：
20070925
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专利附图：
摘要：A non-human transgenic animal that is transgenic for an antibody or fragments thereof and having a phenotype reminiscent of human pathology. The human pathology
includes neurodegenerative syndromes, muscular atrophy/dystrophy and immune disorders. The animals may be used in a method for early diagnosis of neurodegenerative diseases. The method includes monitoring the occurrence of the tau hyperphosphorylation and/or amyloid deposition in the back or lower limb skeletal muscle sample of a subject. Cells are derivable from the non-human transgenic animal and secreting the transgenic antibody. The cells are used for the selection of molecules pharmacologically effective in neurodegenerative and/or muscular pathologies and/or immune disorders. A non-human transgenic animal may be prepared by providing a first non-human transgenic parent animal for the light chain of an antibody and a second non-human transgenic parent animal for the heavy chain of the same antibody, breeding the two transgenic parent animals and selecting the progeny expressing both the light and the heavy chain.
申请人：Antonino Cattaneo,Simona Capsoni,Francesca Ruberti
地址：Trieste IT,Trieste IT,Trieste IT
国籍：IT,IT,IT
代理机构：Law Office of Kenneth K. Sharples
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