丙种球蛋白联合甲基强的松龙对重症病毒性脑炎患儿临床症状及预后的影响

结论 丙种球蛋白联合甲基强的松龙可明显缩短重症病毒性脑炎患儿的临床症状恢复时间及住院时间袁 降低不良反应发生率遥
揖关键词铱 重症病毒性脑炎曰 丙种球蛋白曰 甲基强的松龙曰 临床症状曰 预后
中图分类号院 R512.3
文献标识码院 粤
doi:10.3969/j.issn.1674-4659.2019.10.1399
Effect of Gamma Globulin Combined with Methylprednisolone on the Clinical Symptoms and Prognosis of Children with Severe Viral Encephalitis // LIU Y ue (Pediatric Intensive Care Unit, Shangqiu First People's Hospital, Shangqiu 476000, China) [Abstract] Objective To investigate the effect of gamma globulin combined with methylprednisolone on the clinical symptoms and prognosis of children with severe viral encephalitis. Methods 192 children with severe viral encephalitis were randomly divided into two groups equally. The control group was treated with symptomatic therapy and methylprednisolone, and the observation group was treated with gamma globulin additionally on the basis of the control group. The recovery time of clinical symptoms, hospitalization time, adverse reactions and prognosis were compared between the two groups. Results The antipyretic time, recovery time of paralysed limbs, recovery time of consciousness, convulsion stopping time and hospitalization time of observation group were significantly shorter than those of control group, and the incidence of adverse reactions was significantly lower than that of control group (P <0.05). No significant difference was found in the prognosis between two groups (P >0.05). Conclusions Gamma globulin combined with methylprednisolone can obviously shorten the recovery time of clinical symptoms and hospitalization time, and reduce the incidence of adverse reactions. [Key words] Severe viral encephalitis; Gamma globulin; Methylprednisolone; Clinical symptoms; Prognosis
2019 年 10 月第 26 卷第 10 期
窑1399窑 窑论著窑
渊临床研究冤
丙种球蛋白联合甲基强的松龙对重症病毒性脑炎患儿
临床症状及预后的影响
柳悦 渊商丘市第一人民医院 儿童重症监护室袁 河南 商丘 源苑远园园园冤
揖摘要铱 目的 探讨丙种球蛋白联合甲基强的松龙对重症病毒性脑炎患儿临床症状及预后的影响遥 方法 员怨圆 例重症病毒性脑
炎患儿随机分为两组各 怨远 例遥 对照组给予对症治疗加用甲基强的松龙治疗袁 观察组在对照组基础上加用丙种球蛋白治疗袁 比较
两组的临床症状恢复时间尧 住院时间尧 不良反应 抽搐停止时
间及住院时间均显著短于对照组袁 不良反应发生率显著低于对照组 渊孕 约园援园缘冤遥 两组的预后比较袁 差异无统计学意义 渊孕 跃园援园缘冤遥
病毒性脑炎是指因各种病毒感染脑实质而引起的原发性炎 症袁 属小儿常见疾病遥 重症者可出现不同程度的意识障碍尧 惊 厥尧 精神异常等曰 若不及时治疗袁 可导致死亡或存留严重后遗 症袁 如智力低下尧 瘫痪尧 继发癫痫等袁 危害极大 咱员暂遥 因此袁 给 予重症病毒性脑炎患儿及时有效的治疗具有重要临床意义 咱圆暂遥 基于此袁 本研究旨在探讨丙种球蛋白联合甲基强的松龙对重症 病毒性脑炎患儿临床症状及预后的影响袁 现报道如下遥
员 资料与方法
员援员 一般资料 选取 圆园员苑 年 圆 月至 圆园员怨 年 员 月我院收治的重 症病毒性脑炎患儿 员怨圆 例袁 按照随机数字表法将分为两组各 怨远 例遥 观察组中男 缘员 例袁 女 源缘 例曰 年龄 圆 耀 怨 岁袁 平均 渊源援远圆 依 圆援源源冤 岁曰 病程 圆猿 澡 耀 猿 凿袁 平均 渊员援远源 依 园援猿苑冤 凿曰 临床表现院 发热 苑缘 例袁 呼吸衰竭 猿苑 例袁 反复抽搐 源员 例袁 昏迷或嗜睡 缘圆 例遥 对照组中男 缘远 例袁 女 源园 例曰 年龄 圆 耀 员园 岁袁 平均 渊源援愿圆