急性脑梗死患者血清脂蛋白(a)、超敏C反应蛋白水平的改变及其临床意义

急性脑梗死患者血清脂蛋白(a)、超敏C反应蛋白水平的改变
及其临床意义
王峥;陈伟贤;陆小伟;曾彦英;段丽敏
【期刊名称】《临床神经病学杂志》
【年(卷),期】2012(25)5
【摘要】Objective To explore the changes and its clinical significance of serum levels of lipoprotein (a) [Lp(a)] , high sensitivity C-reactive
protein(hs-CRP) in patients with acute cerebral infarction (ACI). Methods The levels of serum Lp(a) and hs-CRP in 101 ACI patients and 40 normal controls( NC group) were examined by immune-turbidimetry and immune scatter turbidimetry. ACI patients were assessed by national institutes of health stroke scale (NIHSS). The levels of serum Lp (a) and hs-CRP were compared among the patients with different NIHSS score. The relationship between levels of serum Lp(a) and hs-CRP was analyzed. Results The levels of serum Lp (a) and hs-CRP in ACI group were significant higher than those in NC group (all P <0.05 ). The differences of serum levels of Lp(a) and hs-CRP were statistical significance among NIHSS <5,5 ~ 15 and > 15 score sub-groups (all P<0.05). The higher scores of NIHSS, the higher of the serum levels of Lp (a) and hs-CRP. The serum level of Lp (a) was positively related with hs-CRP (r=0.457,P<0.05). Conclusions The levels of serum Lp(a) and hs-CRP are signficantly elevated in ACI patients. Lp(a) and hs-CRP may have cooperative action in ACI onset.%目的探讨急性脑梗死(ACI)患者血清脂
蛋白(a)[Lp(a)]和超敏C反应蛋白(hs-CRP)水平的改变及其临床意义.方法采用免疫比浊法和免疫散射比浊法检测101例ACI患者、40名正常对照者(NC组)的血清Lp(a)和hs-CRP水平.对ACI患者进行美国国立卫生研究院卒中量表(NISSH)评分；比较不同NIHSS评分患者的血清Lp(a)和hs-CRP水平.对ACI患者的血清Lp(a)与hs-CRP水平相关性进行分析.结果 ACI组血清Lp(a)和hs-CRP水平均明显高于NC组(均P＜0.05).ACI组NIHSS评分＜5分、5～15分和＞15分3个亚组之间血清Lp(a)、hs-CRP水平的差异有统计学意义(均P＜0.05)；NIHSS评分越高的亚组,其血清Lp(a)、hs-CRP水平越高.血清Lp(a)与hs-CRP水平之间呈正相关(r=0.457,P＜0.05).结论 ACI患者的血清LP(a)和hs-CRP水平明显增高.并且Lp(a)和hs-CRP在ACI发病中可能有相互协同作用.
【总页数】2页(P383-384)
【作者】王峥;陈伟贤;陆小伟;曾彦英;段丽敏
【作者单位】210029 南京医科大学第一附属医院老年医学科;210029 南京医科大学第一附属医院老年医学科;210029 南京医科大学第一附属医院老年医学
科;210029 南京医科大学第一附属医院老年医学科;210029 南京医科大学第一附属医院老年医学科
【正文语种】中文
【中图分类】R743.3
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