Process for the preparation of high purity buspiro
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专利名称：Process for the preparation of high purity buspiron and the hydrochloride thereof 发明人：Tibor Mezei,Gabor Blasko,Zoltan
Budai,Margit Csorgo,Eva Furdyga,Imre
Klebovich,Laszlo Koncz,Ilona Sztruhar,Attila
Mandi,Kalman Nagy,Klara Reiter nee
Esses,Gyula Simig,Judit Szego,Gyongyi
Vereczkey nee Donath
申请号：US08/274848
申请日：19940714
公开号：US05473072A
公开日：
19951205
专利内容由知识产权出版社提供
摘要：Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)- piperazine- 1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-di one (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine- 1- yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2- yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7, 9-dione thus obtained into the hydrochloride thereof.
申请人：EGIS GYOGYSZERGYAR RT.
代理机构：Beveridge, DeGrandi, Weilacher & Young
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