A MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE US
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专利名称：A MULTICOMPONENT OR
MONOCOMPONENT VACCINE TO BE USED
AGAINST CHAGAS DISEASE
发明人：DE BAEREMAECKER BARROS, CARLOS
申请号：IB2008002923
申请日：20081030
公开号：WO2009056965A3
公开日：
20090723
专利内容由知识产权出版社提供
摘要：The main objective of the present invention is to obtain a vaccine against the Chagas disease, capable of stimulating the immune response against the trans- sialidase virulence factor of the Trypanosoma Cruzi parasite, distinguished by the fact that said vaccine comprises a multicomponent vaccine for the Chagas disease (tripanosomiasis americana) distinguished by the fact that it comprises: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions that codifying one or more immunogenic polypeptides, both portions for the Trypanosoma Cruzi derivates (i.e., T. Cruzi and or a conserved region common to many of them) where the vaccine administration is a protection against the parasite infection, eliminates it or reduces the clinical consequences of said infection. Another objective of the present invention is a monocomponent vaccine against the Chagas disease comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions that codifying one or more immunogenic polypeptides derived from
Trypanosoma Cruzi (i.e. a T. Cruzi and /or a conserved region common to many of them) where the immunogenic portion or the polynucleotides group stimulates an antibody response, of CD4+ Th1 biased T cells or CD8+ T cells against the Trypanosoma Cruzi. This invention also includes: the pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.
申请人：TERRAMARK MARKENCREATION GMBH,DE BAEREMAECKER BARROS, CARLOS 更多信息请下载全文后查看。