TH287 hydrochloride_1638211-05-8_DataSheet_MedChemExpress
洋甘菊提取液MSDS英文版
1. IDENTIFICATION OF THE SUBSTANCE/TREPARATION AND THE COMPANY/UNDERTAKING3.HAZARDS IDENTIFICATION4. FIRST AID MEASURESMATERIAL SAFETY DATA SHEETProduct name:Supplier:Tel:EMERGENCY OVERVIEW: May cause skin irritation and/or dermatitisPrinciple routes of exposure: Inhalation: Ingestion: Skin contact: Eye contact:SkinMay cause irritation of respiratory tract May be harmful if swallowed May cause allergic skin reaction Avoid contact with eyesStatements of hazard MAY CAUSE ALLERGIC SKIN REACTION.Statements of Spill of Leak Label Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.General advice:POSITION/INFORMATION ON INGREDIENTSInhalation:Skin contact:Ingestion:Eye contact:Protection of first – aiders:Medical conditions aggravated by exposure: In the case of accident or if you fell unwell, seek medical advice immediately (show the label where possible).Move to fresh air, call a physician immediately.Rinse immediately with plenty of water and seek medical adviceDo not induce vomiting without medical advice.In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.No information availableNone knownSuitable extinguishing media:Specific hazards:Special protective equipment for firefighters:Flash point:Autoignition temperature:NFPA rating Use dry chemical, CO2, water spray or “alcohol” foam Burning produces irritant fumes.As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gearNot determinedNot determinedNFPA Health: 1 NFPA Flammability: 1 NFPA Reactivity: 0Personal precautions: Environmental precautions: Methods for cleaning up: Use personal protective equipment.Prevent product from entering drains.Sweep up and shovel into suitable containers for disposalStorage:7. HANDLING AND STORAGE5.FIRE-FIGHTING MEASURES6. ACCIDENTAL RELEASE MEASURESRoom temperature Handling:Safe handling advice: Incompatible products:Use only in area provided with appropriate exhaust ventilation.Wear personal protective equipment.Oxidising and spontaneously flammable productsEngineering measures: Respiratory protection: Skin and body protection:Eye protection: Hand protection: Hygiene measures:Ensure adequate ventilation.Breathing apparatus only if aerosol or dust is formed. Usual safety precautions while handling the product will provide adequate protection against this potential effect. Safety glasses with side-shieldsPVC or other plastic material glovesHandle in accordance with good industrial hygiene and safety practice.Melting point/range: Boiling point/range: Density: Vapor pressure: Evaporation rate: Vapor density: Solubility (in water): Flash point:Autoignition temperature:No Data available at this time. No Data available at this time. No data available No data available No data available No data available No data available Not determined Not determinedStability: Stable under recommended storage conditions. Polymerization: None under normal processing.Hazardous decomposition products: Thermal decomposition can lead to release of irritating gases and vapours such as carbon oxides.Materials to avoid: Strong oxidising agents.10. STABILITY AND REACTIVITY9. PHYSICAL AND CHEMICAL PROPERTIES8. EXPOSURE CONTROLS/PERSONAL PROTECTION11. TOXICOLOGICAL INFORMATIONConditions to avoid: Exposure to air or moisture over prolonged periods.Product information Acute toxicityChronic toxicity:Local effects: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness.Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.Specific effects:May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting,headache.Primary irritation: Carcingenic effects: Mutagenic effects: Reproductive toxicity:No data is available on the product itself. No data is available on the product itself. No data is available on the product itself. No data is available on the product itself.Mobility:Bioaccumulation: Ecotoxicity effects: Aquatic toxicity:No data available No data available No data availableMay cause long-term adverse effects in the aquatic environment.12. ECOLOGICAL INFORMATION13. DISPOSAL CONSIDERATIONSWaste from residues/unused products:Contaminated packaging:Waste disposal must be in accordance with appropriate Federal, State and local regulations. This product, if unaltered by use, may be disposed of treatment at a permitted facility or as advised by your local hazardous waste regulatory authority. Residue from fires extinguished with this material may be hazardous.Do not re-use empty containers.UN/Id No:Not regulated14. TRANSPORT INFFORMATIONDOTProper shipping name: Not regulatedTGD(Canada)WHMIS hazard class: Non - controlledIMDG/IMOIMDG – Hazard Classifications Not ApplicableIMO – labels:15. REGULATORY INFOTMATION International Inventories16. OTHER INFORMATIONPrepared by: Health & SafetyDisclaimer: The information and recommendations contained herein are based upon tests believed to be reliable.However, XABC does not guarantee the accuracy or completeness NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOOD, THE MERCHANTABILITY OF THE GOODS, OR THE FITNESS OF THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE. Adjustment to conform to actual conditions of usage maybe required. XABC assumes no responsibility for results obtained or for incidental or consequential damages, including lost profits arising from the use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied.End of safety data sheet。
国际化妆品原料标准中文名称、INCI名、CAS号查询表(2010年版)
序号
1681 5894 10462 12033 1493 1494 1682 1679 1685 8598 10441 5892 5893 5896 5897 5895 8599 6505 6506 8241 8602 6523 66 71 660 14686 8209 8210 1683 3847 8600 3852 3851 3854 3855 3856 3857 3848 4272 8206 14846 4080 3860 3858 3859
中文名称
1,2-丁二醇 1,2-己二醇 1,2-戊二醇 1,3-丙二醇 1,3-双-（2,4-二氨基苯氧基）丙烷 1,3-双-（2,4-二氨基苯氧基）丙烷 HCl 1,4-丁二醇 1,4-丁二醇/琥珀酸/己二酸/HDI 共聚物 1,4-丁二醇二（甲基丙烯酸）酯 1,5-萘二酚 1,5-戊二醇 1,6-己二胺 1,6-己二醇 1,6-己二醇二水杨酸酯 1,6-己二醇二硬脂酸酯 1,6-己二醇蜂蜡酸酯 1,7-萘二酚 10-羟基癸酸 10-羟基癸烯酸 1-甲基乙内酰脲-2-酰亚胺 1-萘酚 1-羟乙基-4,5-二氨基吡唑硫酸盐 1-乙酰萘 1-乙酰氧基-2-甲基萘 2-（2-氨基乙氧基）乙醇 2,2'-硫代双（4-氯苯酚） 2,2'-亚甲基双 4-氨基苯酚 2,2'-亚甲基双-4-氨基苯酚 HCl 2,3-丁二醇
国际化妆品原料标准中文名称目录（2010年版）
序号 INCI名称 中文名称
酸 （C10-18 脂酸甘油三酯类聚甘油-3酯类） 磷酸酯类 （动物）肝水解产物 （动物）睾丸水解产物 （动物）脊髓索带提取物 （动物）脊髓索带脂质 （动物）脊髓脂质提取物 （动物）脐带提取物 （动物）气管水解产物 （动物）乳房提取物 （动物）神经提取物 （动物）胎盘蛋白 （动物）胎盘酶 （动物）胎盘脂质 （动物）心脏水解产物 （动物）心脏提取物 （动物）胸腺水解产物 （动物）胸腺提取物 （镁/钾/硅）（氟化物/氢氧化物/氧化 物） （牛）肝提取物 （牛）睾丸提取物 （牛）骨髓类脂质 （牛）骨髓提取物 （牛）肌肉提取物 （牛）卵巢提取物 （牛）脾提取物 （牛）网膜类脂质 （牛/猪）脑提取物 （日用）香精 （三油酰氧甲基）甲氨基乙醇硫酸酯 （神经）鞘磷脂 （神经）鞘脂类 （四丁氧基）丙基三硅氧烷 （天冬氨酸/谷氨酸）金 （辛/癸）酸异辛酯 （椰油/葵花籽油）酰胺丙基甜菜碱 （月桂/肉豆蔻）基二醇羟丙基醚 1-（3,4-二甲氧基苯基）-4,4-二甲基1,3-戊二酮 1,10-癸二醇 1,2,4-苯三酚三乙酸酯 1,2,4-三羟基苯 1,2,6-己三醇 1
WAters31843
Desolvation gas flow liters/hr 200 to 250 250 to 400 250 to 400 400 to 750
Higher desolvation temperatures give increased sensitivity. However, increasing the temperature above the range suggested reduces beam stability. Increasing the gas flow rate higher that the quoted values lead to unnecessary high nitrogen consumption. Avoid operating the desolvation heater for long periods of time without proper gas flow. To do so could damage the source.
©2004 Waters Corporation
MS Troubleshooting Strategy
Try to simplify -assess impact on lab efficiency -inspect the MS or /MS/MS -try to categorize troubleshoot the easiest to fix items first
Mass Spectrometry
Source: ESI APcI Nano-ESI Mass analyzers: magnetic sectors electric sectors time of flight quadrupole ion trap FT-ICR
新一代成核剂NA287英文介绍资料
• Enables material savings through good mechanical properties • Improves output of polypropylene conversion processes • Helps manage warpage
Plastic Additives 14
Nucleated Virgin polymer
Theoretical analysis: Cooling time reduction
Output improvement vs. cooling time reduction 1400 1200 #parts/year*#cavities 1000 800 600 400 200 0 0 10 20 30 40 50 Cooling Time Reduction (%)
13
Nucleators affect cooling time by ...
• Increasing crystallization temperature and speed
3.0 Heat Flow (mW/mg) 2.5 2.0 1.5 1.0 0.5 0.0 90 110 130 150 Temperature (oC)
30
135
Warpage management for broader choice in coloration and reduced scrap formation
Plastic Additives
17
Differential shrinkage causes warpage
• Shrinkage
28 7
25%氟硅唑可溶粒剂的高效液相色谱分析
以取 得较好 效 果 。在 ６ ７ｌ 用 水量 ４ 情 况下 ， ６ ｌ ｉ２ ５
施 用 ７ ％嘧 菌 ・ 锌 ＷＰ １ ２ ／ｍ ０ 锰 ５ｇｈ ，３ｄ后 霉层 １
农户 的用 药成本 。因此 ，７％嘧 菌 ・ 锌 ＷＰ是 防 ０ 锰
治葡 萄霜 霉病 的较有 前景 的复 配产 品 。
动相 。
称取约 含氟硅唑 ００ 准确 至 ００ ０ 的试 ． ｇ（ ５ ． ０２ 样于 ５ ０ ｍＬ容量瓶 中，用适量 甲醇 超声溶解 ，冷却至 室温后 ，用 甲醇定容至刻度 ，摇匀 ，过滤 ，备用 。
１ － 测定 ．３ ４
２３ 线 性 关 系 曲线 ．
称取 氟硅 唑标 准 品 Ｏ５ｇ（ ． 精确 至 ００ ０ ）于 ． ｇ ０２ ５ Ｌ容 量瓶 中，用 甲醇溶 解 并稀释 至刻 度 ，摇匀 。 ０ｍ 然后 用移 液 管分 别移 取 ２０ ４０ ６０ ８ ， ００ｍＬ于 ．， ．， ．， ． １ ． ０ ５ ０ｍＬ容量 瓶 中 ，用 甲醇溶 解定 容至 刻度 ，摇匀 ， 配成 不 同浓度 的标样 溶液 系列 。在上 述规 定 的液 相 色谱 条件 下 ，测其 相应 的峰面积 值 。以氟 硅 唑质 量 浓度 为横 坐 标 、其 峰面 积 为纵 坐标 ，绘制 线 性关 系
关键词：氟硅唑；高效液相 色谱；分析
中图分类号：Ｔ ５ ． Ｑ ４ ０７ 文献标识码 ：Ａ ｄ ｉ １． ６￣ｉ ｎ１７ ．２ ４２ １． ．１ ｏ： ０３ ９ ．ｓ．６ １５ ８ ．０２０ ０ １ ９ ｓ ４
Ｄｅ ｅ ｍｉ ａ ｉ ｎ ｏ ｌ ｓ ａ ｏ ｅ ２ ％ Ｓ ｂ ＬＣ ｔ ｒ ｎ ｔＯ ｆＦ ｕ ｉ ｚ ｌ ５ ｌ Ｇ ｙ ＨＰ
３ １据 田间观察 ，７％嘧菌 ・ 锌 ＷＰ对 葡萄 黑 ０ 锰 痘 病 、穗轴褐 枯病 、 白腐病 、炭疽 病等 均有 良好 的
萘-甲醇标准溶液液相色谱分析条件研究
萘-甲醇标准溶液液相色谱分析条件研究李锋丽许思思张森孙华许爱华黄清波(山东省计量科学研究院，济南2500U)摘要:用液相色谱仪分析萘_甲醇溶液标准物质，通过研究波长、流动相比例、流速、柱温对杂质峰与目标峰的分离度及对目标物的峰面积、峰高的影响，确定了分析萘-甲醇溶液标准物质的最佳条件:波长275nm;流动相比 例 80%(甲醇：水=80 : 20);流速 0.5 mL/min;柱温 40*C。
关键词：液相色谱仪萘-甲醇波长流动相比例流速柱温DOI：10. 3969/j.issn. 1001-232x.2018. 04. 020Research on analytical conditions of naphthalene- methanol standard solution by liquid chromatography. Li Fengli，Xu Sisi，Z h a n g Se n，S u n Hua，Xu Aihua，H u a n g Q in g b o{S h a n d o n g In s t it u t e of M e tro lo g y，J in a n 250014, C h in a)Abstract：T h e naphthalene-methanol standard solution was analyzed by liquid chromatography.Theinfluences of the wavelength,proportion of mobile phase,flow rate and column temperature on the separation degree of the impurity peaks and target peaks were investigated while the effects on the peak areas and peak heights of the target substances were studied as well.T h e optimum conditions were as follows： 275 n m as the wavelength, 80%(the proportion of methanol to water was 80%) as the proportion of mobile phase, 0. 5 m L/m i n as the flow rate and 40°C as the column temperature.Key words：Liquid chromatography；Wavelength；Proportion of mobile phase；Flow rate；Column temperaturei引言液相色谱仪广泛应用于食品、环境等检测领 域，其工作原理是利用液体混合物在流动相与固定 相中的分配或吸附等差异，由流动相将样品带入色 谱柱中进行分离，经检测器检测进行数据处理后，根据保留时间和峰面积（峰高）进行定性定量分析。
光谱纯溶剂
光
1.06048.0500 1.13720.0009 1.04200.0009 1.00930.1000 1.02950.0500 1.03424.0009 1.03562.0009
Dichloromethane Dichloromethane-D2 min. 99.8% for NMR Dichloromethane-D2 min. 99.95% for NMR Diethyl ether Dimethyl sulfoxide Dimethyl sulfoxide-D6 min. 99.8% for NMR Dimethyl sulfoxide-D6 min. 99.95% for NMR Dimethyl sulfoxide-D6 with TMS (0,1 1.03587.0100 vol.%) 1.11656.0009 min. 99,9% for NMR min. 99.5% for NMR Dimethylformamide-D7 1.00980.0500 Ethanol 1.00980.2500 1.03450.0001 Ethanol-D6 min. 99% for NMR 1.00863.0500 Ethyl acetate 1.13365.0010 Formic acid-D2 min. 99.5% for NMR 1.04718.2500 Isooctane 1.06002.0500 Methanol 1.06002.2500 1.06028.0009 Methanol-D4 min. 99,8 % for NMR 1.06025.0009 Methanol-D4 min. 99.95% for NMR 1.02937.0500 N,N-Dimethylformamide 1.02937.2500 1.04366.0500 n-Heptane 1.04366.2500 1.04372.0500 n-Hexane 1.04372.2500 1.02914.0002 Nitromethane-D3 min. 99% for NMR 1.07179.1000 n-Pentane 1.07161.0100 Paraffin liquid 1.04907.0100 Potassium bromide for IR 1.07475.0009 Pyridine-D5 min 99.8% for NMR 1.01984.1000 tert-Butyl methyl ether 1.00965.0500 Tetrachloroethylene 1.08110.0500 Tetrahydrofuran 1.13364.0009 Tetrahydrofuran-D8 min 99.5% for NMR 1.08183.0010 Tetramethylsilane for NMR 1.08331.1000 Toluene 1.13368.0010 Toluene-D8 min. 99.5% for NMR 1.08262.0025 Trifluoroacetic acid 1.08262.0100 Trifluoroacetic acid 1.13363.0010 Trifluoroacetic acid-D1 min. 99.5% for NMR
雅D-苯甘氨酸甲酯盐酸盐制备及纯化工艺研究-化学工程与技术专业毕业论文
D-苯甘氨酸甲酯盐酸盐制备及纯化工艺研究-化学工程与技术专业毕业论文河北科技大学硕士学位论文IIAbstract=========；暑=；昌昌============；==≈==；穹皇=========；号皇；=兰===昌==暑=======置==宣号=== =：AbstractD。
phenylglycine methyl ester hydrochloride，a type of white crystalline powder and important p harmaceutical i ntermediate，iS a n e ssential active side chain f or t he production of cephalexin，cefaclor,and other IMactam antibiotics．In this paper,the synthesis and crystallization purification technique of D-phenylglycine methyl ester hydrochloride is systematically studied．The study on the synthesis of D—phenylglycine methyl ester hydrochloride．A preliminary synthetic route of D·phenylglycine methyl ester hydrochloride was designed，and sulfoxide chloride method was determinedexperimentally as a preferred syntheticroute．In the experiment，the synthesis technique conditions such as thesequence of adding reagents，the ratio of reagents，the reaction temperature，the reflux time，and the adding rate of sulfoxide chloride were investigated and optimized．After the completion of the reaction，the vacuum azeotropic distillation and cooling crystallization with the temperature controlling should be done to the mother liquor．Finally through the post‘pmcessing，we can get．t11e crystal product of D—phenylglycine methyl ester hydrochloride．The purity of the product detected by using HPLC is more than 98．5％．with the yield more than 96％．The study on the thermodynamics of D-phenylglycine methyl ester hydrochloridecrystallization．Thesolubility and supersolubility of D—phenylglycine methylesterhydrochloride in six pure solvents(water，methanol，ethanol，acetone，ethyl acetate，and toluene)as well as in two kinds of binary mixed solvents with different compositions (methanol—ethyl acetate and methanol—toluene)were measured under the conditions of atmospheric pmssure and the temperature range of 283．1 5K-333．1 5K by using Laser Dynamics Method．Then the Apelblat equation，CNIBS／Redlich．Kister equation．and NRTL equation were used to correlate the data of solubility，and it showeda satisfactoryresult．Finally，thermodynamic properties in the dissolution process wereanalyzed systematically，and changes of the free energy of standard molar enthalpy，Standard molar entropy and Standard Gibbs of D-phenylglycine methyl ester hydrochloride in the dissolution process in different solvents were calculated．The study on thermodynamics of crystallization of D—phenylglycine methyl ester hydrochloride provides a theoretical reference and data base forthe development of its crystallizationtechnique．IIlThe crystallization kinetics of D．phenylglycine methyl ester hydrochloride was studied by batch dynamic methods．Samples of different times were measuredunderdifferent processing conditions．Then the CSD Was analyzedby laserCrystallization dynamic models of D．phenylglycine methyl ester granulometer．hydrochloride were established based on the mass balance equation and population balance equation．ARertransformation of moments on theexperimental data，the mathematical models for crystal growth rate and secondary nucleation rate were obtained，and the operating parameterswhich affected the crystallographicprogress were analyzed．The study on the crystallizationtechnique of D-phenylglycine methyl esterhydrochloride．The crystallization technique of D．．phenylglycinemethyl ester hydrochloride Was studied on the basis of crystallization thermodynamics and dynamics．The influence of crystallization method and process conditions on the quality and vield of product Wasstudied．A new crystallization and purification technique ofD-phenylglycinemethyl ester hydrochloride Was developed．The crystals produced by this new technique is of high purity，high yield，and good color level(1evel 1)，and their particle size increaSed anduniformed obviously．With stablequality of the product，low production COst aS wellas easy operation control，this technique has applied for China National invention patent．Andthousand tons has been realized．the industrialization of the annualoutput ofKey words D-phenylglycine methyl ester hydrochloride；Synthesis technique；Crystallization thermodynamics；Crystallization kinetics；The crystallizationtechniqueIV物理量名称及符号表物理量名称及符号表4一Apelblat方程参数；尸一压强；彳一晶体外表积：尸一系统搅拌强度量；40一指数因子；Qi-粒数密度；B—Apelblat方程参数：B一为生函数；Qi-引入结晶器的晶浆流量；矿一总成核速率；Q一引出结晶器的晶浆流量；啷一均相成核速率；，．一晶核半径；召s一二次成核速率；R一气体常量；C--Apelblat方程参数；R2一相关指数；C一溶液主体浓度；仅，，一与溶剂有关的非随机参数；Ci一溶液界面浓度；Gl，一NRTL模型参数；C。
高效氯氰菊酯MSDS
其他：该物质对环境有危害，应特别注意对水体的污染。
第十二部分：生态学资料
生态毒理毒性：无资料
生物降解性：在土壤和植物中含有的微生物加速甲基对硫磷的生物降解.在无菌土壤中的降解速率相当低.在普通土壤中该农药在7天内被降解95％,而在灭菌土壤中仅降解20％.甚至在高剂量情况下经2～3个月,微生物亦可使其完全降解。
高效氯氰菊酯MSDS
高效氯氰菊酯化学品安全技术说明书(MSDS)
第一部分：化学品名称
化学品中文名称：
高效氯氰菊酯、顺式氯氰菊酯；高效灭百可；（R,S）-α-氰基-3-苯氧基苄基（1R,3R）-3-（2，2-二氯乙烯基）-2，2-二甲基环丙烷羧酸酯?
化学品英文名称：Betacypermethrin
技术说明书编码：
第五部分：消防措施
危险特性：遇明火、高热可燃。与氧化剂可发生反应。遇高热分解释出高毒烟气。若遇高热，容器内压增大，有开裂和爆炸的危险。
有害燃烧产物：一氧化碳、二氧化碳、氮氧化物、氯化氢、氰化物。
灭火方法及措施：消防人员须佩戴防毒面具、穿全身消防服，在上风向灭火。尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。灭火剂：雾状水、泡沫、干粉、二氧化碳、砂土。
危险货物编号：61904
UN编号：2588
包装标志：无资料
包装类别：无资料
包装方法：塑料袋或二层牛皮纸袋外全开口或中开口钢桶；两层塑料袋或一层塑料袋外麻袋、塑料编织袋、乳胶布袋；塑料袋外复合塑料编织袋（聚丙烯三合一袋、聚乙烯三合一袋、聚丙烯二合一袋、聚乙烯二合一袋）；塑料袋或二层牛皮纸袋外普通木箱；螺纹口玻璃瓶、塑料瓶、复合塑料瓶或铝瓶外普通木箱；塑料瓶、两层塑料袋或两层牛皮纸袋（内或外套以塑料袋）外瓦楞纸箱。
盐酸利多卡因注射剂遗传毒性杂质研究_NormalPdf
Journal of China Pharmaceutical University2020，51（4）：466-471学报盐酸利多卡因注射剂遗传毒性杂质研究冼芷然1，孙春萌2，骆雪芳1*，钟文英1**（1中国药科大学理学院药物质量研究中心，南京211198；2中国药科大学药学院，南京211198）摘要确定2，6-二甲基苯胺为盐酸利多卡因注射液中遗传毒性杂质，N-氯乙酰-2，6-二甲基苯胺为潜在遗传毒性杂质，建立LC-MS/MS方法，用色谱柱Agilent ZORBAX Eclipse Plus C18（4.6mm×250mm，5μm）对原料、自制制剂及原研制剂进行遗传毒性杂质研究。
研究结果表明自制制剂中杂质2，6-二甲基苯胺与N-氯乙酰-2，6-二甲基苯胺除由原料引入外，可能分别由氧化条件或碱性条件下降解引入，为盐酸利多卡因注射液的遗传毒性风险评估和工艺优化提供参考与指导。
关键词盐酸利多卡因注射液；遗传毒性杂质；LC-MS/MS中图分类号R917文献标志码A文章编号1000-5048（2020）04-0466-06doi：10.11665/j.issn.1000-5048.20200412引用本文冼芷然，孙春萌，骆雪芳，等.盐酸利多卡因注射剂遗传毒性杂质研究［J］.中国药科大学学报，2020，51（4）：466–471.Cite this article as：XIAN Zhiran，SUN Chunmeng，LUO Xuefang，et al.Profiling of genotoxic impurities in a lidocaine hydrochloride injec‐tion［J］.J China Pharm Univ，2020，51（4）：466–471.Profiling of genotoxic impurities in a lidocaine hydrochloride injection XIAN Zhiran1,SUN Chunmeng2,LUO Xuefang1*,ZHONG Wenying1**1Drug Quality Research Center,College of Science,China Pharmaceutical University;2School of Pharmacy,China Pharmaceutical University,ChinaAbstract2,6-dimethylbenzenamine was determined as a genotoxic impurity in lidocaine hydrochloride injec‐tion,and2-chloro-N-(2,6-dimethylphenyl)acetamide was determined as potential genotoxic impurity.An LC-MS/ MS method was established to research the profiling of genotoxic impurities in active pharmaceutical ingredients (API),homemade preparation and reference preparation on column Agilent ZORBAX Eclipse Plus C18(4.6mm×250mm,5μm).The results show that in the homemade preparation the2,6-dimethylbenzenamine and the 2-chloro-N-(2,6-dimethylphenyl)acetamide may be degraded under oxidation condition and alkaline condition in addition to the introduction from API preparation process.This study provides guidance for genotoxic risk assess‐ment and prescription process optimization of lidocaine hydrochloride.Key words lidocaine hydrochloride injection;genotoxic impurities;LC-MS/MS盐酸利多卡因（lidocaine hydrochloride）为临床上常制成盐酸利多卡因注射剂应用于局部麻醉药［1］和抗心律失常药物等［2-3］。
无机物熔点
>500 dec >150 dec 2.42 220 dec 188.28
382
3.98
dec 73 3000 >1460 ≈1525 2053
135 dec
1.72 3.255 2.56 2.78 3.97 3.44 2.0 2.40
68.925 68.925
≈3000
Hale Waihona Puke 82 dec 2550182.40
No. Name
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 Actinium Actinium bromide Actinium chloride Actinium fluoride Actinium iodide Actinium oxide Aluminum Aluminum ammonium sulfate Aluminum ammonium sulfate dodecahydrate Aluminum antimonide Aluminum arsenide Aluminum borate Aluminum boride Aluminum borohydride Aluminum bromate nonahydrate Aluminum bromide Aluminum bromide hexahydrate Aluminum carbide Aluminum chlorate nonahydrate Aluminum chloride Aluminum chloride hexahydrate Aluminum diacetate Aluminum ethanolate Aluminum fluoride Aluminum fluoride monohydrate Aluminum fluoride trihydrate Aluminum hexafluorosilicate nonahydrate Aluminum hydride Aluminum hydroxide Aluminum hydroxychloride Aluminum hypophosphite Aluminum iodide Aluminum iodide hexahydrate Aluminum lactate Aluminum nitrate Aluminum nitrate nonahydrate Aluminum nitride Aluminum oleate Aluminum phosphate Aluminum metaphosphate Aluminum oxide (corundum) Aluminum oxyhydroxide Aluminum palmitate Aluminum perchlorate nonahydrate Aluminum phosphide
HPLC法测定愈创木酚磺酸钾原料药中有关物质
HPLC 法测定愈创木酚磺酸钾原料药中有关物质摘要：目的HPLC法测定愈创木酚磺酸钾原料药中有关物质。
方法以十八烷基硅烷键合硅胶为填充剂(4.6 mm×250 mm，5 µm)，以冰醋酸水溶液（每1000ml水中加入5ml冰醋酸，用三乙胺调节pH至3.5）为流动相A，以甲醇为流动相B，梯度洗脱（0～5 min，95%A；5～25 min，95% A→75% A；25～40 min，75% A→60% A；40～40.1 min，60% A→95% A），检测波长为279nm；柱温为30℃；流速为1.20ml/min；进样量20 µL。
结果：各杂质平均回收率在90%~110%之间，定量限浓度小于忽略限度（0.05%）。
结论该方法灵敏度高、准确度好，可用于愈创木酚磺酸钾原料药中有关物质的测定。
关键词： HPLC 愈创木酚磺酸钾原料药有关物质愈创木酚磺酸钾为刺激性祛痰药，通过刺激支气管黏膜腺体分泌，使痰液变稀容易咳出，常作为复方祛痰镇咳类口服液的主要成分之一[1]。
美国药典(USP)42版[2]收载的愈创木酚磺酸钾原料药为羟基甲氧基苯磺酸钾半水化合物（C7H7KO5S H2O），未对磺酸钾的取代位置作出规定，JP17版药典[3]中规定愈创木酚磺酸钾为4-羟基-3-甲氧基苯磺酸钾单体。
KP X药典中收载的也是4-羟基-3-甲氧基苯磺酸钾单体[4]。
本研究将美国药典收载的另一构型（3-羟基-4-甲氧基苯磺酸钾）作为已知杂质研究，同时还考察了愈创木酚（起始物料）、邻苯二酚（愈创木酚的起始物料）。
本研究采用普通C18柱，高有机相比例洗脱，延长色谱柱寿命，且方法准确，灵敏度较高。
1仪器与试药仪器Agilent 1260 InfinityII高效液相色谱仪（安捷伦科技有限公司）；Sartorius型电子天平（赛多利斯有限公司），PHS-3C型pH计（上海越平科技仪器有限公司）。
试药甲醇（色谱纯；TEDIA）；冰醋酸（分析纯；西陇科学股份有限公司）；三乙胺（分析纯；国药集团化学试剂有限公司）；水为纯化水。
谷氨酸受体iGluR_抑制剂_激动剂
iGluRIonotropic glutamate receptorsiGluR (ionotropic glutamate receptor) is a ligand-gated ion channelthat is activated by the neurotransmitter glutamate. iGluR are integralmembrane proteins compose of four large subunits that form acentral ion channel pore. Sequence similarity among all knownglutamate receptor subunits, including the AMPA, kainate, NMDA,and δ receptors.AMPA receptors are the main charge carriers during basaltransmission, permitting influx of sodium ions to depolarise thepostsynaptic membrane. NMDA receptors are blocked by magnesiumions and therefore only permit ion flux following prior depolarisation.This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.iGluR Inhibitors & Modulators(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.(S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist (S)-Willardiine is a potent agonist of AMPA/kainate receptors with24-Hydroxycholesterol is a natural sterol, which serves as a positive,N-Methyl-d-Aspartate (NMDA) receptorsRmodulator7-Chlorokynurenic acid is a selective antagonist at the glycinecomplexintoreuptake of glutamate7-Chlorokynurenic acid sodium salt is a selective antagonist at theN-methyl-D-aspartate receptorreuptake of glutamate antagonist and anCat. No.: HY-16713Cat. No.: HY-16713A Cat. No.: HY-12499Cat. No.: HY-N2370 Cat. No.: HY-B2121Cat. No.: HY-100811 Cat. No.: HY-100811A Cat. No.: HY-15073CFM-2 is a selective non-competitive AMPAR antagonist.CIQ is a subunit-selective potentiator of NMDA receptors containing CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.receptor antagonist.ion-channel antagonist receptor/ion channel site to produce a Coluracetam(MKC-231) is a new choline uptake enhancerCX546 is a selective positive AMPAR modulator; the prototypicalCat. No.: HY-102053Cat. No.: HY-12503Cat. No.: HY-18699Cat. No.: HY-12508Cat. No.: HY-15066Cat. No.: HY-101809Cat. No.: HY-17553Cat. No.: HY-12505Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to . Dynorphin A (1-10) of 42.0 μM.Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptor positive Felbamate (FBM) is a potent nonsedative anticonvulsant whose Felbamate hydrate (FBM) is a potent nonsedative anticonvulsant Flupirtine(D 9998) is a selective neuronal potassium channel opener Flupirtine Maleate(D 9998) is a selective neuronal potassium channelopener that also has NMDA receptor antagonist propertiesCat. No.: HY-P1594Cat. No.: HY-12881Cat. No.: HY-10937Cat. No.: HY-B0184Cat. No.: HY-B0184ACat. No.: HY-17001ACat. No.: HY-17001Cat. No.: HY-100785NMDAα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ( )AMPAIbotenic acid has agonist activity at both the N-methyl-D-aspartate ( ) and trans-ACPD or metabolotropic quisqualate (Q )m IC87201, an inhibitor of PSD95-nNOS protein-protein interactions,-dependent NO and cGMP formation.Ifenprodil tartrate is a novel N-methyl-D-aspartate (NMDA) receptor antagonist that selectively inhibits receptors containing the NR2Bagonistbeta-adrenergic receptors of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride isKynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting <b >NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting <b >NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selectiveCat. No.: HY-19243Cat. No.: HY-103228 Cat. No.: HY-N2311Cat. No.: HY-100457 Cat. No.: HY-12882A Cat. No.: HY-B1270 Cat. No.: HY-100806Cat. No.: HY-107512LY451395(Mibampator) is a potent and highly selective potentiator MDL 105519 is a potent and selective antagonist of glycine binding NMDA receptor H]glycine binding in vitro and in Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0Mephenesin is an NMDA receptor antagonist, is a centrally acting MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro ) receptors Cat. No.: HY-10934Cat. No.: HY-15085Cat. No.: HY-16312Cat. No.: HY-17555Cat. No.: HY-B0365ACat. No.: HY-B1283Cat. No.: HY-101620Cat. No.: HY-12506)NMDA mimicking theaction of glutamate, the neurotransmitter which normally acts at that NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A,NR2C, NR2D, hERG-channel and α1-adrenergic receptor.Noopept (GVS-111) is a medication promoted and prescribed in NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial ) agonist used in the study receptor positive allosteric modulator.Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 6Cat. No.: HY-106408Cat. No.: HY-17551Cat. No.: HY-12962Cat. No.: HY-17456Cat. No.: HY-P7060Cat. No.: HY-101216Cat. No.: HY-B0369ACat. No.: HY-B1126PEPA is an allosteric modulator of AMPA receptors; binds to theGluA2o and GluA3o LBDs and can be utilized as an indicator ofreceptorAMPARs of 263 and 296 nM,gamma-aminobutyric acid (GABA), used in treatment of a wide rangeProcyclidine hydrochloride is a potent anti-cholinergic agent, and is QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitiveantagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D,Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for majorCat. No.: HY-12509Cat. No.: HY-14451 Cat. No.: HY-104020A Cat. No.: HY-B0585 Cat. No.: HY-B1487Cat. No.: HY-15703 Cat. No.: HY-16728Cat. No.: HY-16728BRo 25-6981 Maleate is a potent and selective activity-dependentblocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations , with potent SDZ 220-581 is a potent, competitive antagonist at the NMDASDZ 220-581 ammonium salt is a potent, competitive antagonist at SDZ 220-581 Hcl is a potent, competitive antagonist at the NMDASunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher SYM 2206 is a novel, potent, non-competitive AMPA receptor Talampanel is a potent and selective AMPA-receptor antagonist, is a Cat. No.: HY-13993ACat. No.: HY-101600Cat. No.: HY-13059Cat. No.: HY-13059ACat. No.: HY-13059BCat. No.: HY-17550Cat. No.: HY-18689Cat. No.: HY-15079antagonist NMDAof 10 -240455 is a potent and selective N-methyl D-aspartate ( )NMDAYM 872 is a selective antagonist of the glutamate receptor subtype,α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)ZK200775(Fanapanel; MPQX) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA,ZK200775 hydrate(Fanapanel; MPQX) is a highly selectiveAMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate,ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibitsHY-W018061Cat. No.: HY-19391 Cat. No.: HY-15072Cat. No.: HY-15069 Cat. No.: HY-15069A Cat. No.: HY-100456。
锂离子电池电解液添加剂物性数据
锂离子电池电解液添加剂物性数据化学名称环己基苯（CHB) 亚硫酸亚乙酯（EＳ、ＤＴO）硫酸亚乙酯（DＴD) 亚硫酸丙烯酯（PＳ）碳酸亚乙烯酯(VC）别名苯基环己烷，苯基环乙烷亚硫酸乙二醇酯、乙二醇亚硫酸酯、亚硫酸乙烯酯硫酸乙烯酯、硫酸乙二醇酯、乙二醇硫酸酯、亚乙基硫酸酯Ｔrimetｈyｌene Suｌｆiｔe1，3,２-Diｏxathｉane 2－oxide1,3-Dｉoｘo-２-one英文名称Cycloheｘyｌ beｎzｅnｅＥthylｅｎe suｌｆite Ethyｌｅｎe Ｓｕｌｆaｔe Propylenｅsｕlfite Ｖｉnyｌene ｃarbｏｎａte CAＳ号８2７-5２-1 3741－3８-6 １０72-53-5 4176－55-0 87２－36-6分子式C12Ｈ16C2H４O３ＳC2H４O４ＳC３H6Ｏ3S C３Ｈ2O3分子结构分子量16０.２6 108．1２124 122.１8６.05熔点/沸点/闪点7~8℃/2３９~24０℃／98．０？/1７2～1７４℃／79℃9７～９９℃/?／? ?/76／？19~2２℃/１６5℃/７３℃密度(ｇ/mＬ at 2５℃）0.95 １.426 １.3225 1.3５5ｇ/ｍL 粘度（40℃)折光率 1.5230±０．0050 1.4４5~1．447 1.420～1．422 外观无色油状液体无色液体白色结晶或白色结晶性粉末无色液体无色透明液体或白色固体特性易溶于醇、丙酮、苯、四氯化碳、二甲苯、不溶于水和甘油DTO的含量≥98%，氯乙醇含量≤1０00ppm水溶性11.５ G/100 MＬ用途用于锂二次电池电解液的添加剂，具有防过充性能。
应用于锂电池高温溶剂。
作锂离子电池电解质的有机溶剂,又可作为锂离子电池电解液的添加剂，锂离子电池电解质添加了DTO 后将呈现出优异的儲存稳定性，可以提高电解液的低温性能,同时可以防止PC 分子嵌入石墨电极。
常见的羟基的保护与脱保护方法
目录1.简介 (2)2.硅醚 (2)三甲基硅醚(T M S-O R) (3)叔丁基二甲基硅醚(T B D M S-O R) (4)叔丁基二苯基硅醚(T B D P S-O R) (4)3.苄醚 (6)4.取代苄醚 (7)5.取代甲基醚 (8)6.四氢吡喃醚 (9)7.烯丙基醚 (10)1.前言羟基广泛存在于许多在生理上和合成上有意义的化合物中，如核苷，碳水化合物、甾族化合物、大环内酯类化合物、聚醚、某些氨基酸的侧链。
另外，羟基也是有机合成中一个很重要的官能基，其可转变为卤素、氨基、羰基、酸基等多种官能团。
在化合物的氧化、酰基化、用卤代磷或卤化氢的卤化、脱水的反应或许多官能团的转化过程中，我们常常需要将羟基保护起来。
在含有多官能团复杂分子的合成中，如何选择性保护羟基和脱保护往往是许多新化合物开发时的关键所在，如紫杉醇的全合成。
羟基保护主要将其转变为相应的醚或酯，以醚更为常见。
一般用于羟基保护醚主要有硅醚、甲基醚、烯丙基醚、苄基醚、烷氧甲基醚、烷巯基甲基醚、三甲基硅乙基甲基醚等等。
羟基的酯保护一般用的不多，但在糖及核糖化学中较为多见。
2.羟基硅醚保护及脱除硅醚是最常见的保护羟基的方法之一。
随着硅原子上的取代基的不同，保护和去保护的反应活性均有较大的变化。
当分子中有多官能团时，空间效应及电子效应是影响反应的主要因素。
在进行选择性去保护反应时，硅原子周围的空间效应，以及被保护分子的结构环境均需考虑。
例如，一般情况下，在TBDMS基团存在时，断裂DEIPS( 二乙基异丙基硅基) 基团是较容易的，但实际得出的一些结果是相反的。
在这些例子中，分子结构中空间阻碍是产生相反选择性的原因。
电子效应的不同也会影响反应的选择性。
对于两种空间结构相似的醇来说，电子云密度不同造成酸催化去保护速率不同，因此可以选择性去保护。
这一点对酚基和烷基硅醚特别有效：烷基硅醚在酸中容易去保护，而酚基醚在碱性条件下更容易去保护。
降低硅的碱性还可以用于改变Lewis酸催化反应的结果，并且有助于选择性去保护。
D-色氨酸甲酯盐酸盐
分子式: C12H15ClN2O2
分子量: 254.71
EINECS号: 231-385-5
相关类别: Amino Acids Derivatives;Amino Acids;胺基酸;Tryptophan [Trp, W];Amino Acids and Derivatives;Amino Acids 13C, 2H, 15N;Amino Acid Methyl Esters;Amino Acids (C-Protected);Biochemistry;氨基酸的酯类;Amino hydrochloride;Amino Acids & Derivatives;Amino Acid Derivatives;Peptide Synthesis;Tryptophan;氨基酸及其衍生物
中文名称: D-色氨酸甲酯盐酸盐
中文同义词: H-D-TRP-OME·HCL;D-色氨酸甲酯;D-色氨酸甲酯盐酸盐;D-色氨酸甲脂盐酸盐;D-色氨酸甲酯盐酸盐,他达拉非中间体
英文名r hydrochloride
英文同义词: D-TRYPTOPHAN METHYL ESTER;D-TRYPTOPHAN METHYL ESTER HCL;D-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE;D-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE SALT;D-TRYPTOPHAN-OME HCL;H-D-TRP-OME HCL;D-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE 99%;D-TRP.OME.HCL
制备：以D-色氨酸为原料,先甲酯化反应,生成的D-色氨酸甲酯盐酸盐
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全球 NMR 耗材 引领 60 年
百灵威
百灵威科技有限公司成立于 1992 年，始终以“为科研和生产提供世界一流的产品和服务”为宗旨，致力于超精细化学品的研发与 制造。经过近二十年的发展，百灵威已具备为化学、分析、生物、材料、物理及药物研发等领域提供近五十万种产品和专业服务 的能力。 百灵威拥有一支强大的具有丰富经验和创新能力的研发团队，在江苏、河北设立的两个研发中心可迅速研发出毫克至数百公斤级 的医药、生化、材料等中间体及特殊高端化学品，并可为客户定制合成各类产品，尤其擅长小分子药物中间体以及催化剂配体的 合成。 百灵威人坚信“发展民族科技”的理念，坚持依靠中国人自己的智慧和力量， 不断建设和发展位于潮白河畔的现代化工业生产基地，发挥百灵威在尖端技术研究、敏捷制造和系统性物流管理等方面的突出优 势，积极地将中国的各种高端化合物推荐给国际同行，为促进中国化学事业发展，推动世界文明与和谐进步而奋斗不息。 百灵威的使命 促进科技和工业发展，造福人类……
管壁厚度(mm) 平均凸度(µm)
包装
0.27
<60>
50只/塑料筒装
0.27
<60>
50只/塑料筒装
0.43
<60>
50只/塑料筒装
0.43
<60>
100只/纸盒装
0.43
<60>
50只/塑料筒装
0.43
<60>
100只/纸盒装
0.60
<60>
50只/塑料筒装
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