胶原酶膏对射频引起的皮肤擦伤的作用

胶原酶膏对射频引起的皮肤擦伤的作用
Silvana A Schellini;Ivana Pereira;Erika Hoyama;Claudia H Pellizon;Carlos R Padovani
【期刊名称】《国际眼科杂志》
【年(卷),期】2008(8)7
【摘要】目的:无线电频率是用于治疗皮肤皱褶和病损的一种方法,但是它又可以导致表皮的侵蚀性损伤,本研究的目的是观察胶原酶膏剂在这种皮肤损伤后的修复中的作用.方法:本研究采用无线电频率在豚鼠的背侧中线部位造成皮肤的侵蚀性损伤,30只豚鼠被随机地分为两组,一组用生理盐水处理患处,另一组则用胶原酶涂敷皮肤损伤部位,两组都是每天两次处理皮损处.两组动物分别在盐水和胶原酶处理后1,7,30和60d处死,采取肉眼、组织学和形态学进行观察和评估,结果进行统计学分析.结果:在第1和第15d内,与用生理盐水处理豚鼠皮肤患处组相比较,采用胶原酶涂敷后的豚鼠皮肤患处显示很快的愈合及更轻的炎性细胞浸润,在第1d和第7d,生理盐水组则表现出增厚的表皮和变薄的真皮,但是在第30d和第60d,两组之间已经没有显著的差别.结论:本观察的结果提示在无线电频率治疗导致的侵蚀性皮肤损伤中,应用胶原酶膏可以加速皮肤患处的修复.%AIM: Radiofrequency is one of the methods used to treat wrinkles and skin lesions, but its application may result in an abrasive wound. The purpose of this study was to evaluate the effect of collagenase ointment on the epithelial healing of an abrasive wound induced by a radiofrequency system.METHODS: An abrasive wound was produced using radiofrequency at the dorsal midline of 30 guinea pigs, which were randomly divided into 2 groups: one group were treated with saline solution and the other group treated with collagenase ointment;
both used twice daily. The animals were sacrificed at 1, 7, 15, 30 and 60 postoperative days.Macroscopic,histological and morphometric evaluations were performed and the results were submitted to statistical analysis.RESULTS:The animals treated with collagenase ointment presented accelerated healing process and less inflammatory cell infiltration than the saline solution treated animals from one to fifteen postoperative days. Morphometric evaluation showed a thicker epidermis and a thinner dermis layer in the saline solution group at one and seven postoperative days, but significant differences between both groups were not observed at thirty and sixty postoperative days.CONCLUSION: According to our results the use of collagenase ointment may accelerate the healing process of a radiofrequency induced abrasive wound.
【总页数】3页(P1296-1298)
【作者】Silvana A Schellini;Ivana Pereira;Erika Hoyama;Claudia H Pellizon;Carlos R Padovani
【作者单位】巴西圣保罗州立大学博图卡图医学院眼科;巴西圣保罗州立大学博图卡图医学院眼科;巴西圣保罗州立大学博图卡图医学院眼科;巴西圣保罗州立大学生物科学研究所;巴西圣保罗州立大学生物科学研究所
【正文语种】中文
【中图分类】R77
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