HEMATOPOIETIC STEM CELL GENE THERAPY
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专利名称：HEMATOPOIETIC STEM CELL GENE THERAPY
发明人：BOYD, RICHARD
申请号：IB2001002739
申请日：20011012
公开号：WO02/031110P1
公开日：
20020418
专利内容由知识产权出版社提供
摘要：The present disclosure provides methods for gene therapy utilizing hematopoietic stem cells, lymphoid progenitor cells, and/or myeloid progenitor cells. The cells are genetically modified to provide a gene that is expressed in these cells and their progeny after differentiation. In a preferred embodiment the cells contain a gene or gene fragment that confers to the cells resistance to HIV infection and/or replication. The cells are administered to a patient in conjunction with treatment to reactivate the patient's thymus. The cells may be autologous, syngeneic, allogeneic or xenogeneic, as tolerance to foreign cells is created in the patient during reactivation of the thymus. In a preferred embodiment the hematopoietic stem cells are CD34+. The patient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In a preferred embodiment, this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines or combinations thereof.
申请人：MONASH UNIVERSITY
地址：AU
国籍：AU
代理机构：DAVIES COLLISON CAVE 更多信息请下载全文后查看。